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Topic: Anyone with an intermediate oncotype?

Forum: Stage I Breast Cancer — Meet other members with a Stage I breast cancer diagnosis to share information and support.

Posted on: Jan 23, 2011 03:00AM

Lovelillian wrote:

I have an oncotype score of 24 and was getting a hard sell for chemotherapy from my oncologist. The clinical trial clearly stated that a 24 falls in the middle of the middle and that this group showed "no significant benefit of chemotherapy but it can't be ruled out." Having worked for a clinical trial org, I did a ton of research on both oncotype dx and TAILORx before making my decision.

Anyway, I wasn't buying what she was selling and chose not to do chemo. Anyone else out there that had to make this difficult decision? I feel like I am damned if I do and damned if I don't!

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Apr 17, 2011 10:12PM Pompeed wrote:

Another 21 here. With tamox and without chemo, risk is 13% over ten years. That's 87 women out of a 100 without recurrence in a decade and 13 with. 

 With chemo, MAYBE risk is improved to 91 women without recurrence out of a 100 over ten years and 9 women with.  And that's only a MAYBE because it is not known whether chemo will really change my risk by 4 or not. 

 Chances are better that I am already one of 87 rather than 1 of 13.

 First oncologist: "Doesn't matter how the oncotype comes back.  I'm trying to save your life.  You really  have to take the chemo.  It's not that bad."

Second oncologist: "You're on the edge of low / middle risk and we're not exactly sure where the lline is.  The chemo decision is up to you.  I'm OK if you decide to take it and I'm OK if you don't.  But you have to take the Tamox or Aromatase inhibitors because not taking those increases your risk to 25% and I don't like that number."

Third oncologist: "I'd feel better if you take the chemo.  Or at least try it.  You can always stop if the side effects are intolerable.  If you decide not to take the chemo, you really have to take the Tamox or the Aromatase inhibitors."

Me:  I've just been through hell to all of them.  I'm trying to get well again.  Why should I take the chemo when we don't know whether it will do me any good at all and I'll spend this entire year getting sick for five months and then trying to get at least as well as I am again after that.  That will take up the entire year.  For what?  I might be dead of something else well before the ten years expires. 

I'm not willing to give up a year of mostly decent health and everything that means in my life right now while I can enjoy it in the hopes that the chemo will be beneficial sometime over the next ten years.  If I'm already one of 87 ten years from now I will never know whether the chemo did me any good at all and I will have made myself sick as a dog for nothhing. 

"I'm not willing to waste a year of what I can do right now making myself sick and then trying to get over being sick from making myself sick.  If it comes back, I'll deal with it then.  No chemo for me.  Thanks all the same." 

First onco: blew up; insisted I'm putting my life in danger but unable to show that to me in a risk / benefit analysis that makes sense.  I know what the risks of chemo are and this MD cannot show me the benefit for taking that risk.

Second: OK: reasonable decision.

Third: disappointed that I would not try the chemo but OK with decision.

For the people in the middle, it's a damn minefield.

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Apr 18, 2011 12:54AM, edited Apr 18, 2011 12:59AM by allmylove

I think that while the oncotype "recurrance" score matters, the more important part of it is predictability of how much chemo will benefit the specific person. I think some of you are confused with the whole recurrance rate and hormone drugs.. so basically you should think about recurrance for oncotype score as distance or systematic recurrance, which means having cancer elsewhere - this is what chemo is for. sometimes surgery misses cancer cells in the breast or in the blood, and since chemo is given in the blood stream, it'll attack the cancer cells escaped from surgery. this is also how people get distance recurrances and metastatic cancer - where the cancer has traveled elsewhere. for local recurrances radiation or mastectomy takes care of that.

note - not that chemo doesnt also help with local recurrances, but its mainly for distance. chemo just covers a wider area since you're getting it everywhere the blood travels

the difference between tamoxifen and arimidex isnt even worth the discussion - usually premenopausal women takes tamoxifen and postmenopausal takes arimidex. if you're ER positive, which you should be to get the oncotype dx test, you'll most likely take either or. 

so edwards750: your test score is still valid just because you took arimidex instead of tamoxifen, dont worry 

i hope im explaining things well - feel free to ask me specific questions again or i guess you can just ask oncologists for more professional answers =)

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Apr 18, 2011 01:48AM TinaT wrote:

edwards750: The Oncotype DX score is based on Tamoxifen, but my oncologist told me that indications are that the numbers for Arimidex are actually a few percentage points better.  The test does look at your tumor, then makes predictions based on a database of other patients.  ER+ women who are pre-menopausal women are given Tamoxifen (an estrogen blocker) and post-menopausal women can take either Tamoxifen or Arimidex (an aromatase inhibitor).  They each have side effects so your doctor will help you decide based on other health factors.

Additional areas of lobular neoplasia and multiple ADH throughout left breast found at mastectomy. Oncotype DX = 18 (Opted out of chemo)

Dx 12/8/2010, ILC, <1cm, Stage Ib, Grade 1, 0/1 nodes, ER+/PR+, HER2-Dx 12/18/2010, DCIS, <1cm, Stage 0, Grade 1, 0/1 nodes, ER+/PR+Surgery 02/16/2011 Mastectomy (Both); Lymph Node Removal (Left); Reconstruction: Tissue expander placement (Both)Hormonal Therapy 04/15/2011 ArimidexSurgery 08/24/2011 Reconstruction: Breast implants (permanent) (Both)Surgery 04/08/2013 Reconstruction: Breast implants (permanent) (Both)
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Apr 18, 2011 03:47AM letterchick wrote:

I had bi-lateral mastectomy, estro+, HR2 neg, no lymph involvement. Stage 1 grade 2. Unfortunately , I had 3 tumors. Oncotype results 17, 18, and 24. My onc recommends TCx4 and Tamoxifen. OK with the hormone therapy. I am 39 (-will be 40 in 2 wks, not the way I planned...but manageable). Do not feel risks outweigh benefits w/ intermediate score. I am a vegetarian and very fit. I can't imagine spending the remainder of the year allowing someone to poison me and MAKE me sick. Fear infections and low immunity. Want to see natureopathic onc, but not covered and expensive. Willing to take my chances and boost supplements and maybe increase diet to raw foods. anyone else going that route? Hard decision to make...afraid to regret it someday. LAW OF ATTRACTION: think about the results you want, work hard to attain and it will happen!

Tracey

Dx 1/27/2011, IDC, 1cm, Stage I, Grade 2, 0/3 nodes, ER+/PR-, HER2+
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Apr 18, 2011 03:49AM letterchick wrote:

by the way, going for 2nd opinion tomorrow. have a feeling it will be same, but maybe she will give me something else to think about...

Tracey

Dx 1/27/2011, IDC, 1cm, Stage I, Grade 2, 0/3 nodes, ER+/PR-, HER2+
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Apr 18, 2011 10:12AM marybast wrote:

The research base for the Oncotype DX was with women taking Tamoxifen. Arimidex is a bit more effective than Tamoxifen for certain cancers. The score you get predicts your recurrence risk if you were taking Tamoxifen. If you're taking another drug, you just extrapolate... for me, Arimidex reduces the risk a bit more than Tamoxifen.

See my blog at http://theonlygateisnow.blogspot.com

Dx 12/22/2010, ILC, 1cm, Stage I, Grade 1, 0/2 nodes, ER+/PR-, HER2-
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Apr 18, 2011 07:06PM kira1234 wrote:

The Onco score that you see first is the chance of a distance reacurance of the cancer. The second score is what your score is assuming you use some kind of estrogen reducing meds. In my case I had a 24% chance it would return somewhere else in my body. By taking some kind of an estrogen reducing medicine it brought my score down to 16. After that you see how much chemo will reduce your chance of getting cancer else where again. In my case it lowered my chances by 2%.

I know it's very confusing.

Dx 6/1/2010, ILC, <1cm, Stage Ia, Grade 1, 0/1 nodes, ER+/PR+, HER2-Surgery 07/10/2010 Lumpectomy (Left); Lymph Node Removal: Sentinel Lymph Node Dissection (Left)Radiation Therapy 08/03/2010 InternalHormonal Therapy 10/05/2010 Aromasin
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Apr 18, 2011 07:26PM, edited Apr 19, 2011 01:41PM by Rennasus

I'm Stage 1B, grade 1. My oncotype score was 16 ... 10% recurrence score. I had a BMX and started Tamox almost a month ago. No chemo.

The oncotype test does not take into account what kind of surgery you have.

Here is how my onco explained my situation to me... my recurrence risk is more like 5% (rather than 10%) because although I had cancer in only one breast, I removed them both and that halves your risk.

BMX & TE 2/3/11; incision revisions 2/19/11, 3/28/11, 4/26/11; right TE removed 7/6/11; put back 12/1/11; exchange Sept. 5, 2012. Tamoxifen: Mar 2011-Sept 2013; Femara Nov 2013 to ? Blogging at: http://thebigcandme.blogspot.com/

Dx 12/8/2010, IDC, 3cm, Stage Ib, Grade 1, 0/8 nodes, ER+/PR+, HER2-Surgery 02/03/2011 Mastectomy (Right); Prophylactic Mastectomy (Left); Reconstruction: Tissue expander placement (Both)Surgery 02/03/2011 Lymph Node Removal: Sentinel Lymph Node Dissection, Axillary Lymph Node Dissection (Right)Surgery 02/19/2011 Reconstruction (Right)Hormonal Therapy 03/24/2011 TamoxifenSurgery 03/28/2011 Reconstruction (Right)Surgery 04/26/2011 Reconstruction (Right)Surgery 07/06/2011 Reconstruction (Right)Surgery 12/01/2011 Reconstruction (Right)Surgery 09/05/2012 Reconstruction: Breast implants (permanent) (Both)Hormonal Therapy 11/01/2013 Femara
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Apr 18, 2011 08:29PM Thatgirl wrote:

How do they determine the score? Is this from the actual tumor ?

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Apr 18, 2011 08:29PM jan508 wrote:

Thatgirl:

Yes the test is done on the actual tumor.

Jan

Dx 8/6/2010, ILC, 2cm, Stage II, Grade 2, 0/2 nodes, ER+/PR+, HER2-
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Apr 18, 2011 08:30PM kira1234 wrote:

rennasus, The ochotype test isn't looking at those factors it is looking at the DNA of the tumor itself. In my case and maybe yours as well my BS was sure he got everything, and the Onc. agreed, so in there opinion the Oncotype test ws wrong for me. Who know if they are right or not, we jsut have to go with who we trust.

Dx 6/1/2010, ILC, <1cm, Stage Ia, Grade 1, 0/1 nodes, ER+/PR+, HER2-Surgery 07/10/2010 Lumpectomy (Left); Lymph Node Removal: Sentinel Lymph Node Dissection (Left)Radiation Therapy 08/03/2010 InternalHormonal Therapy 10/05/2010 Aromasin
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Apr 24, 2011 01:47AM HeleneS wrote:

My score was 23.  Malignancy was .5 cm.  No chemo, but I am on Lupron (and tamoxifen), 

Dx 2008, IDC, <1cm, Stage Ia, Grade 2, 0/4 nodes, ER+/PR+, HER2-
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Apr 24, 2011 07:40AM thegoodfight wrote:

My oncotype was 18 and I went forward with chemo, simply because I was afraid not to and might regret it years from now.  I don't know what the future holds, but for me I needed the serenity of not questioning myself if I had a recurrance.  It has been almost three years since dx and in spite of chemo and radiation I feel great and even though it was not a picnic, it was all doable.  The decision is individual for everyone.  Each of us just needs to be comfortable with our own decisions.

Dx 7/14/2008, IDC, 3cm, Stage IIa, Grade 3, 0/1 nodes, ER+/PR+, HER2-
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Apr 24, 2011 02:01PM BioAdoptMom3 wrote:

GabbyCal, based on what I have been told recently and read, the chemo and hormone therapy decreases the chances of recurrance elsewhere in the body, while the surgery and radiation (for someone who had a lumpectomy) decreases the chances of cancer recurring in the breast.  Be prepared for any suggestion from your onco though.  I had a oncotype of 19 with a distant recurrance rate of 12% and my MO definitely wants me to do chemo.  I start this Friday.  You having a grade 1 tumor (mine was a 3) may make a big difference though.  Just want you to be prepared for his/her POSSIBLE suggestion of chemo. 

((((HUGS)))), prayers and good luck to you!

Nancy

Nancy

Dx 1/13/2011, IDC, 1cm, Stage I, Grade 3, 0/7 nodes, ER+/PR+, HER2-
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Apr 24, 2011 03:13PM Valgirl wrote:

I do belive they look at the grade of the tumor along with the oncotype.   Chemo works on more aggressive tumors.   My oncotype was 16 (higher end of low risk) and my grade was 1.  No chemo and my Onc said no one would recommed chemo for me.   My sister in law had same stats grade 1 but intermediate oncotype grade 23 and no chemo either.

Lumpectomy , 30 Rads, No Chemo , Arimidex for 5 years

Dx 9/17/2010, IDC, <1cm, Stage I, Grade 1, 0/3 nodes, ER+/PR+, HER2-
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Apr 25, 2011 01:29PM edwards750 wrote:

Thank you Tina. This is all so confusing not to mention scary. I am just relieved my insurance company paid for the test because I know it is very expensive and the last thing any of us need is more medical bills. My ONC was ambivalent about chemo for me which is why she recommended the test. Oncologists are finding out they are overtreating some patients so the test is a good barometer for treatment and for predicting recurrence. We all know there is no exact science but from what I have heard the test is being used more and more by oncologists with favorable results. I have to admit I was so relieved not to have to make the choice of doing chemo or not. It was pretty much made for me. diane

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Apr 25, 2011 02:26PM, edited Apr 25, 2011 02:29PM by worldwatcher

Kira your post: "The ochotype test isn't looking at those factors it is looking at the DNA of the tumor itself. In my case and maybe yours as well my BS was sure he got everything, and the Onc. agreed, so in there opinion the Oncotype test ws wrong for me. Who know if they are right or not, we jsut have to go with who we trust.

I had problems finding an oncologist that I trusted and refused chemo, and when I found someone I liked, although I had had a lumpectomy and the five-day radiation treatment, this doctor wanted an OncotypeDX test on my tumor.

I am so thankful that he ordered the test. My original pathology had my tumor at HER2 positive, and I was trying to find someone who would prescribe Herceptin without chemo.  The Oncotype test showed that not only were the ER results incorrect in the original lab report, the Oncotype showed that instead of HER2 + I was just barely on the low end of HER2 equivocal!  I know this is something that happens very infrequently, but I thank God it happened for me. He not only ordered the test, but his office contacted the Oncotype people and arranged that if my insurance refused payment, they would do it for free. 

My OncotypeDX score was 26,  in the high intermediate range, but I'm 71, and my age was a big factor in the chemo decision.

My onc said that since the Oncotype test was on the actual DNA and not some lab tech counting spots under a microscope, the Oncotype was in his opinion the more accurate and he believes EVERY tumor should be tested via the DNA.

I am on Tamoxifen, which he said in his 35 years of practice he has had good results with.  In February, he pronounced me NED.  I will see him again in May.

As you say, Kira.."we just have to go with who we trust."  I was uneasy with my lab results because the test from the biopsy was equivocal, but the FISH test after surgery was positive...and the same lab did both tests.

Lumpectomy, 7/2010, clean PET scan 8/2010, Contura five-day rads, No chemo. Tamox 3/11, clean bone scan 5/2011,clean mammo/ultrasound 8/2012, small seroma gradually shrinking with no problems.

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Apr 25, 2011 05:36PM kira1234 wrote:

worldwatcher, I don't think you have followed my history. I almost died from the 1 chemo I had. It took 5 months for me to heal. I as well as you had a 24 score. My first Onc. felt I should have chemo, and never really listened to me when I told her I felt my body wasn't ready to handle chemo so soon after surgery and mammasite radiation. I was only 2 weeks after the radiation treatments before chemo started. So in 2 weeks I had 2 surgerys plus 1 week of mammasite 2 times a day. By the beginning of the 8th week I had started chemo.

I also had 3 tests on the DNA from 3 different places. 2 agreed Oncotype test differed, I have always wondered about that.

Dx 6/1/2010, ILC, <1cm, Stage Ia, Grade 1, 0/1 nodes, ER+/PR+, HER2-Surgery 07/10/2010 Lumpectomy (Left); Lymph Node Removal: Sentinel Lymph Node Dissection (Left)Radiation Therapy 08/03/2010 InternalHormonal Therapy 10/05/2010 Aromasin
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Apr 25, 2011 05:50PM worldwatcher wrote:

I  don't think I have seen your history...my, what you have suffered through!  I just knew that come what may, I wasn't going to put my ancient body through chemo.  Too many stories similar to yours from acquaintances and friends.

I, too had a Onc who refused to listen to me...that's why it took me from July to Feb. to finally begin with one that I trust.  I see SO many posts from ladies here about oncs that are just plain inflexible.

I had my surgery and Contura balloon rads within about six weeks, and even though both procedures were relatively incident free (they still took a lot out of my stamina),  I knew that quality of life meant too much for me to blindly accept the chemo that was recommended...taxoterre was part of the combo.

I hope that you are doing well now.

Lumpectomy, 7/2010, clean PET scan 8/2010, Contura five-day rads, No chemo. Tamox 3/11, clean bone scan 5/2011,clean mammo/ultrasound 8/2012, small seroma gradually shrinking with no problems.

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Apr 25, 2011 06:29PM kira1234 wrote:

worldwatcher, yes i am doing much better now. I'm not quite as old as you 57, but I agree I should never have done the chemo. By the way had the same contura balloon treatments. I now have an Onc. I totally trust. I asked the BS for one he trusted. To be honest he was really fed up with the one I was using as well. She totally blamed him and the radiologist for the problems, and refused to even work with him. By the way he is with Mofitt so not a nobody in my eyes.

Dx 6/1/2010, ILC, <1cm, Stage Ia, Grade 1, 0/1 nodes, ER+/PR+, HER2-Surgery 07/10/2010 Lumpectomy (Left); Lymph Node Removal: Sentinel Lymph Node Dissection (Left)Radiation Therapy 08/03/2010 InternalHormonal Therapy 10/05/2010 Aromasin
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Apr 25, 2011 08:52PM worldwatcher wrote:

Kira,

It really is good to feel that trust in your doctor.  I think it makes all the difference when your mental attitude is OK with the treatments prescribed.  I'm happy you are feeling better now.

BTW, I just want to leave a note for those who are thinking about the Accelerated Radiation Treatments...I had the Contura procedure of five days with two treatments each day in late August, and now, eight months later I have had NO residual effects from the treatment.   I think that if one is careful that their radiologist is well versed and experienced it is a safe and effective alternative.

Lumpectomy, 7/2010, clean PET scan 8/2010, Contura five-day rads, No chemo. Tamox 3/11, clean bone scan 5/2011,clean mammo/ultrasound 8/2012, small seroma gradually shrinking with no problems.

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Apr 27, 2011 10:06AM, edited Apr 27, 2011 05:59PM by elimar

My Onco score was 18 which, while technically called intermediate, did not seem high enough for me to want to subject my body to chemo.  I think the chemo would have only given me a 2-3% greater benefit against recurrance.  My doc usually won't recommend chemo unless the benefit is more like 5%, so we were in agreement on that.  My nodes were clear and I had high percentages on the ER/PR receptors, so I figured Tamox. would give me the systemic protection.  Personally, if I were at the high end of intermediate, I think I would have opted for chemo.

Dx 6/24/2009, IDC, <1cm, Stage I, Grade 2, 0/2 nodes, ER+/PR+, HER2-
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Apr 27, 2011 02:17PM raincitygirl wrote:

I also had an oncotype 24 with no positive nodes or vascular invasion.  I saw four oncs - got a "you must do chemo", "you definitely shouldn't do chemo", and 2 "you could go either way".   Originally I made a decision based in fear and started chemo, but I didn't stop reading, researching, and thinking about my decision.  I stopped just about halfway through.  I read more about the lack of benefit for ER+ patients without other involvement.  I learned about my ki-67 score.  I made a decision that I will now live with comfortably.  I did 5 of 12 CMF treatments, radiation and am now on Arimidex.

No need to feel lonely :)

Driving with the top down every day that I can....

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Apr 27, 2011 05:51PM kira1234 wrote:

worldwatcher, I agree the Conturia radiation was fine. I had no burning nor pain form it. I was a bit tired, but after 5 days 2 times a day not unusually I would expect. The one thing I would add, make sure your radiaologist has done quite a few before having it done. As I was told the more they have done the better they are at it.

Dx 6/1/2010, ILC, <1cm, Stage Ia, Grade 1, 0/1 nodes, ER+/PR+, HER2-Surgery 07/10/2010 Lumpectomy (Left); Lymph Node Removal: Sentinel Lymph Node Dissection (Left)Radiation Therapy 08/03/2010 InternalHormonal Therapy 10/05/2010 Aromasin
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Apr 28, 2011 12:29PM NormaJean65 wrote:

TinaT:

Giving Tamoxifen to any woman that still has a uterus is a no-no.  Sets her up for a higher risk of developing endometial cancer.

I have a question about the scores you all refer to on your individual Oncotype test.  Which scores are you looking at.......the "Breast Cancer Recurrence Score" or the "Average Rate of Distant Recurrence"?  My Breast Recurrence Score was 100% w/o any.tmt and the Distant Recurrence Score was 34%. 

I did chemo due to my HERS2+  was literally off the chart. Knowing that there could be a few cancerous cells "floating around" in the blood stream from either the biospsy (more likely) or the surgery.  My Onco gave me 6 tmts of Taxotere, Carboplatin along with Herceptin (for 52 wks.).  Plus after the "combos" were finished I was put on Arimadex that caused too many SE so now am on Femara.  I even offered to have the other breast removed and was told it wouldn't change the tmt plan I needed to be on.

No matter what each of us decide to do, I believe that for most of us there will always be a question mark as to whether or not it was enough.  It truly is a personal decision to make for each & every one of us trying to fight this horrific & ugly disease that alters our life to some degree forever.  I for one have decided NO MORE CHEMO-LAND for me, will finish the 5 remaining tmts of the Herceptin (triple dose every 3 wks.now) and whatever amomatase inhibitor that works for me AND THAT IS ALL!!  I am so tired of slicing & dicing, poking & prodding, blood work & scans....... I simply want to live my life with peace & joy for the time God has left for me.  I have done what I could do, now it's in His hands.  I never wanted to live to be 90 or 100 !!!

Norma Jean

Dx 6/29/2010, IDC, <1cm, Stage I, Grade 3, 0/6 nodes, ER+/PR-, HER2+Surgery 07/19/2010 Mastectomy (Right); Prophylactic Mastectomy (Left)Chemotherapy 08/26/2010 carboplatin, TaxotereTargeted Therapy 08/26/2010 HerceptinHormonal Therapy 01/01/2011 Tamoxifen
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Apr 28, 2011 12:36PM elimar wrote:

Your Oncotype score has two numbers and it's hard to confuse them.  One is just a value number that places you in a low, mid, or high probability for recurrence (assuming the use of Tamox.)  The other is given as a percentage, and that is probability for metastasis (distant recurrance.) 

Dx 6/24/2009, IDC, <1cm, Stage I, Grade 2, 0/2 nodes, ER+/PR+, HER2-
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Apr 28, 2011 03:53PM NormaJean65 wrote:

Okay.  To clarify my Oncotype test results my Breast Cancer Recurrence SCORE is 100 and the distal recurrence was 34% (which on my copy is the second number listed).  Gee, sure wish my score was only in the 20's or30's.  Looking at my first page the percentage number does refer to Tamox use, but as I stated before Tamoxifin cannot be giving to EVERY woman.  I would venture a guess & say that statement by Genomic was in a general context, not a recommendation that applies to only women who take Tamox.  Tamoxfin is one of the first proven useful as adjuvant therapy to chemo.  Now we have more choices to apply to different dx of bc.

Sadly either way we are all in the same boat.

Norma Jean

Dx 6/29/2010, IDC, <1cm, Stage I, Grade 3, 0/6 nodes, ER+/PR-, HER2+Surgery 07/19/2010 Mastectomy (Right); Prophylactic Mastectomy (Left)Chemotherapy 08/26/2010 carboplatin, TaxotereTargeted Therapy 08/26/2010 HerceptinHormonal Therapy 01/01/2011 Tamoxifen
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Apr 28, 2011 04:21PM elimar wrote:

The stats assume Tamox. use, because that is the drug all the studies were done under.  Women taking the AIs actually have shown slightly better outcomes than the Tamox. users, but the Genomic test corrolates with the old tried and true Tamox.  As long as you are taking an adjuvant hormonal therapy, you should be in roughly the same ballpark as Tamox. users on your RS score, and your statistical probabilities. 

Don't forget, the OncoScore is basically a guideline whether or not chemo would benefit you.  In your case, NormaJean65, I don't think there is too much ambiguity in the scores you got.

Dx 6/24/2009, IDC, <1cm, Stage I, Grade 2, 0/2 nodes, ER+/PR+, HER2-
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May 2, 2011 08:48PM Pompeed wrote:

There is an endometrial risk with tamox but that risk is easily manageable. 

Get a baseline biopsy prior to tamox and then get REGULAR check ups with the gyn thereafter.

The women who get endometrial cancer are, generally speaking, women who did not have adequate reproductive health care, i.e., regular check ups.\

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May 2, 2011 09:53PM Lee7 wrote:

Has anyone posted info about RxPonder trial by SWOG?  It sounds similar to the TailorX trial currently running only this is for 1-3 node positive ER+ women with OncoScores of 25 or less.

They are seeing if that group can be spared chemo, and only use hormonal therapy.

http://www.caring4cancer.com/go/cancer/news?NewsItemId=45275

Dx 10/2010, IDC, Stage IIa, ER+/PR+, HER2-

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