Just wondering if anyone else has this combination. I just found out the results of my genetic testing and have yet to meet anyone with the same.
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LISAMG Joined: Jul 2009 Posts: 158 |
Oct 5, 2009 11:04 pm
LISAMG wrote:
BRCA 2 breast cancers are often HER2+, since this mutation has more er/pr positive tumors. This is more common than you may think and with the BRCA1 gene, triple negative cancers occur more often. Hope you are being followed by breast surgical onc and gyn/onc as well. I encourage you to seek more support/info. with your positive status by visiting www.facingourrisk.org . We are the only organization devoted to both breast/ovarian hereditary cancers. There are messageboards, hotlines, local outreach programs all over the country, an annual 2 day conference, and newsletters as well. Where are you located? Happy to help you anyway I can . Best wishes. |
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phoenixsmom… Joined: Jun 2009 Posts: 49 |
Oct 7, 2009 02:01 pm
phoenixsmom wrote:
Although I appreciate the support, I don't believe you are correct. Her2+ has nothing to do with estrogen and progesterone receptors, it has to do with a protein. I am PR+ by only 10% and ER-. It is very uncommon to find Her2+ in a BRCA2 inherited breast cancer. I was hoping to have a response from someone with the same diagnosis, but so far I have had none. Please see these sources and others if you still disagree with me. I discussed this in detail with the head of the genetics department at the cancer clinic in London, Ontario. http://www.ncbi.nlm.nih.gov/pubmed/15933754 http://www.termedia.pl/magazine.php?magazine_id=14&article_id=2560&magazine_subpage=ABSTRACT http://jco.ascopubs.org/cgi/content/full/20/9/2310 (under "discussion") Diagnosis: 3/14/2009, ILC, 6cm+, Stage IIIa, PR+, HER2+ |
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mmm5 Joined: Aug 2008 Posts: 495 |
Oct 7, 2009 08:13 pm
mmm5 wrote:
PHX go back a ways on the Her2 thread, Lexislove started a thread on this some months ago and there were several ladies on there that were HER2 and braca2 positive. Look about 2=3 months ago. Diagnosis: 4/4/2008, IDC, 1cm, Stage I, Grade 3, 0/4 nodes, ER+/PR+, HER2+ |
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phoenixsmom… Joined: Jun 2009 Posts: 49 |
Oct 7, 2009 09:34 pm
phoenixsmom wrote:
Thanx. I will look. Diagnosis: 3/14/2009, ILC, 6cm+, Stage IIIa, PR+, HER2+ |
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phoenixsmom… Joined: Jun 2009 Posts: 49 |
Oct 7, 2009 09:45 pm
phoenixsmom wrote:
Okay so I looked. Not very helpful that only one person so far as I can find has the her2 and brca2 thing. Diagnosis: 3/14/2009, ILC, 6cm+, Stage IIIa, PR+, HER2+ |
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mmm5 Joined: Aug 2008 Posts: 495 |
Oct 7, 2009 09:47 pm
mmm5 wrote:
I think there was 2 or 3 if I recall. Elaine and Helena were both braca 2 and that is just the ladies that post on Her2 threads and we don't have that many. Try going over to HER2support.com and you will most likely find more. Diagnosis: 4/4/2008, IDC, 1cm, Stage I, Grade 3, 0/4 nodes, ER+/PR+, HER2+ |
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phoenixsmom… Joined: Jun 2009 Posts: 49 |
Oct 8, 2009 10:00 pm
phoenixsmom wrote:
I think that is still a very small # considering the many people on this forum (hundreds). I think I am the only one at my hospital anyway. I left a message to speak with my onc, especially now that my mom has been diagnosed too. Diagnosis: 3/14/2009, ILC, 6cm+, Stage IIIa, PR+, HER2+ |
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suepen Joined: Nov 2009 Posts: 7 |
Nov 7, 2009 08:12 pm
suepen wrote:
My oncologist says that the gene testing is NOT accurate and to wait 5 years before considering it. Diagnosis: 10/13/2009, ILC, 1cm, Stage I, Grade 3, 0/5 nodes, ER+/PR+, HER2+ |
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lauramc Joined: Sep 2009 Posts: 5 |
Nov 7, 2009 08:23 pm
lauramc wrote:
I am Her2+ and BRCA2+ but my current breast cancer is ER-/PR-. I got tested for the gene because of my young age. Diagnosis: 5/20/2009, IDC, 2cm, Stage II, Grade 3, ER-/PR-, HER2+ |
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Faith316 Joined: Jul 2009 Posts: 153 |
Nov 7, 2009 10:47 pm
Faith316 wrote:
I had this conversation with my surgical oncologist just this week. He told me that HER2 positive women were not as likely to have the genes as HER2 negative women. DX 4/08 IDC, ER-, PR-, HER2+, Stage IIB, Grade 3, lumpectomy, 2/8 nodes, 4 AC, 12 wks. Taxol, Herceptin, 30 rads., DX with IBC in 6/09 while still in active treatment. Now Stage III. Currently on Xeloda, Tykerb. Surgery to follow.
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phoenixsmom… Joined: Jun 2009 Posts: 49 |
Nov 11, 2009 01:26 pm
phoenixsmom wrote:
Thank you for saying so Faith. That is what I was told also. My mom was also recently diagnosed with breast cancer and she has the BRCA II gene. She won't know her Her2 status until she has her surgery in a couple of weeks. Diagnosis: 3/14/2009, ILC, 6cm+, Stage IIIa, PR+, HER2+ |
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shadow2356 Joined: Sep 2009 Posts: 51 |
Nov 15, 2009 12:52 pm
shadow2356 wrote:
Hello! I am ER/PR- and Her2+. My doctor said it is very indicative of an inherited cancer. My mother and grandmother(maternal) had breast cancer. My first cousin on Mom's side had it too. All premenapausal I got tested for BRCA and was negative. They all said if I retest in 5 years when they learn to check for more mutations they would bet it will be positive. I think there is a lot they don't know MaryEllen, 44, Mom to Julianna, 20 months, bilateral mastectomy with immediate DIEP 10/09/09
Diagnosis: 8/14/2009, IDC, 1cm, Stage I, Grade 3, 0/4 nodes, ER-/PR-, HER2+ |
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phoenixsmom… Joined: Jun 2009 Posts: 49 |
Nov 17, 2009 01:20 pm
phoenixsmom wrote:
Hopefully in 5 years they will know so much more! It definitely sounds like it runs in the family. We are in the process of telling our family right now about the gene. Diagnosis: 3/14/2009, ILC, 6cm+, Stage IIIa, 0/7 nodes, PR+, HER2+ |
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