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Oct 6, 2008 09:40PM otter wrote:
Okay, so now I'm really confused.
I was just starting to believe some of the papers I've read lately that hint at an association between LE and previous or concurrent inflammation. Some papers even suggest that inflammation plays an important role in persistent LE.
Try googling "lymphedema" and "inflammation", and you'll see what I mean. Although most of those papers are still very early and are dealing with pathogenesis of LE rather than its treatment, it didn't take me long to start thinking maybe NSAIDs and other anti-inflammatory drugs might help relieve the swelling of LE.
Here's an example of some of the stuff I've read. Ironically, the page is from the "Lymphedema People" website: http://www.lymphedemapeople.com/phpBB3/viewtopic.php?f=6&t=1116
So, along comes this thread, with supportive statements from Lymphedema People, saying that ibuprofen is contraindicated in LE because it increases the swelling.
I went to my favorite pharm site, www.rxlist.com, to see if I could find a warning like the one Debbie got about her ibuprofen. I read the whole entry for "Motrin", which is one of the old-time, high-dose, prescription forms of ibuprofen. This is all I could find that might suggest an increased risk of swelling from ibuprofen:
NSAIDs including MOTRIN tablets, can lead to onset of new hypertension or worsening of pre-existing hypertension, either of which may contribute to the increased incidence of CV events. Patients taking thiazides or loop diuretics may have impaired response to these therapies when taking NSAIDs. NSAIDs, including MOTRIN tablets, should be used with caution in patients with hypertension. Blood pressure (BP) should be monitored closely during the initiation of NSAID treatment and throughout the course of therapy.
Congestive Heart Failure and Edema
Fluid retention and edema have been observed in some patients taking NSAIDs. MOTRIN tablets should be used with caution in patients with fluid retention or heart failure.
So, maybe people who already have systemic problems with fluid retention might see it worsen if they take high-dose ibuprofen. But, does that risk also extend to those of us who take an occasional Advil for a stiff neck or headache? And, what about the "new" theory that chronic inflammation may be a component of LE? Wouldn't ibuprofen help with the inflammatory component?
I guess maybe I'll stop reading now. I'm also thinking maybe each of us has our own group of factors that influence how we'll react to things...including ibuprofen.
Dx IDC, Stage I, Grade 2, 0/3 nodes, ER+/PR-, HER2-