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Jun 6, 2011 05:40 PM lrr4993 wrote:
I did TCx4. I was given the choice of this or the AC/T combo which is more aggressive. I chose the TC. I learned after the fact that TC has been found to be reasonably effective with metaplastic. Again, take this all with a grain of salt because this type is really not understood very well, but I read that it tends to have a lesser response to chemo. But I read one article that was a retrospective on treatment of this type at some place in miami that said it was effective about 50% of the time - the best number I have seen regarding metaplastic.
I did the lumpectomy. In part by choice but also in part because i wanted that thing out of me immediately and that was the quickest route. Mine had a 98% ki-67, meaning that 98% of the cells were duplicating . . . a very high speed growth. So, I did not hestitate to take it out and rejected chemo before surgery because of the risk of it growing during chemo. You should ask lots of questions about this. And I would push for quick appointments. I think metaplastics tend to always be fast growers, which raises the risk of spread. Mine was removed within 10 days of diagnosis. I have a friend who had a similar ki-67 (don't know if she was metaplastic, but i don't think so) and her onco insisted on removal of it immediately . . . she had her lumpectomy two days after diagnosis. A lot of stuff you will read says to take your time and make careful decisions because breast cancer grows slowly . . . that is not always correct.
I did radiation after chemo.
One thing to ask about, particularly if you talk to an expert, is whether you are a true metaplastic. I was told that mine was not "a true metaplastic" meaning that it was only partially metaplastic. I am not sure I buy my onco's explanation of this, but I did test it with my rad onco and she explained it the same way, so maybe it is correct. I feel like it is either metaplastic or not - partial does not make sense to me, but what do I know? LOL.
I have been fine since. I had a very easy time with chemo - was able to work full time with little difficulty. Hair loss was the worst part, but a good wig helps with that. Rads were not difficult at the time, but I am having some ongoing soreness from that which bothers me, particular when sleeping on that side. I am told this can last up to 2 years. Great.
I had my first follow up mammo two weeks ago and it looked good. However, because of scar tissue from surgery/rads and dense breasts, I will not feel comfortable until my annual MRI in august.
Diagnosis: 8/6/2010, IDC, Stage Ib, Grade 3, 0/5 nodes, ER-/PR-, HER2-