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Topic: Metformin-Anyone on this trial?

Forum: Clinical Trials, Research, News, and Study Results — Share your research articles, interpretations and experiences here. Let us know how these studies affect you and your decisions.

Posted on: Feb 18, 2011 03:22AM

Cat123 wrote:

My onc suggested I go on this trial after I finish chemo.  Is anyone else on this trial?

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Posts 601 - 630 (688 total)

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Nov 21, 2012 06:30PM purple32 wrote:

wow zoo!

I am on metformin , but not in trial.

Mine never changed that much. Metformin is known for NOT causing serious drops in blood sugar in fact!

If you are not at significant risk for LE , you may want to ask your DR about a home glucose meter and test now and then.  Be SURE to test  on your ' non affected' side.

Lymphedema on LEFT. NO radiation. 2 clean nodes. purple32. Hope is our light ... in the night.

Dx 3/2012, IDC, <1cm, Stage I, Grade 1, 0/2 nodes, ER+/PR+, HER2-Surgery 05/01/2012 Lumpectomy (Left)
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Nov 28, 2012 10:10AM cp418 wrote:

Well I brought up the topic of Metformin with my oncologist and he pushed it aside as still under multiple studies and not conclusive yet.....  I think I was getting put off but he did not shut the door on it --  as I said I was very interested.  Frustrating that he showed no interest in the article I brought in.....

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Nov 29, 2012 04:42PM purple32 wrote:

Well I brought up the topic of Metformin with my oncologist and he pushed it aside as still under multiple studies and not conclusive yet.....


There are really no good ' conclusions' on anything!  Nobody is claiming it as a cure, and it is a relatively harmless drug.

Why not call him on Monday and  message that you have thought it over and you would like a trial run or it if he wouldnt mind prescribing.

couldnt hurt to just ask!

My endo dr gave it to me and my PCP said it was harmless at best.

Good Luck!

Lymphedema on LEFT. NO radiation. 2 clean nodes. purple32. Hope is our light ... in the night.

Dx 3/2012, IDC, <1cm, Stage I, Grade 1, 0/2 nodes, ER+/PR+, HER2-Surgery 05/01/2012 Lumpectomy (Left)
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Nov 29, 2012 07:06PM Outfield wrote:

Purple,

Endocrinologists and PCP's will by the nature of their jobs prescribed metformin probably every day they have been at work.  It's very, very commonly used because it's the A#1 first line medication for such a common disease.  But oncologists  generally don't treat diabetes.  It makes total sense that Endo's and PCP's would be comfortable prescribing it off-label, but an oncologist might not.

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Nov 29, 2012 07:08PM purple32 wrote:

Exactly, outfield!
Good reason to ask the PCP I guess  :>)

Lymphedema on LEFT. NO radiation. 2 clean nodes. purple32. Hope is our light ... in the night.

Dx 3/2012, IDC, <1cm, Stage I, Grade 1, 0/2 nodes, ER+/PR+, HER2-Surgery 05/01/2012 Lumpectomy (Left)
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Dec 3, 2012 08:17AM cp418 wrote:

http://www.medpagetoday.com/HematologyOncology/OvarianCancer/36210?utm_content=&utm_medium=email&utm_campaign=DailyHeadlines&utm_source=WC&xid=NL_DHE_2012-12-03&eun=g376694d0r&userid=376694&email=jlong@i-review.com&mu_id=5369993

Diabetes Drug May Boost Ovarian Ca Survival

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Dec 3, 2012 09:06AM IsThisForReal wrote:

That's quite a difference in rates!

Lymphedema

Dx 11/30/2009, IDC, 2cm, Stage IIb, Grade 2, 2/12 nodes, ER+/PR+, HER2+Surgery 12/30/2009 Lumpectomy (Left); Lymph Node Removal: Axillary Lymph Node Dissection (Left)Chemotherapy 03/17/2010 carboplatin, TaxotereTargeted Therapy 03/17/2010 HerceptinHormonal Therapy 08/03/2010 TamoxifenRadiation Therapy 08/03/2010 ExternalSurgery 08/24/2011 Prophylactic Mastectomy (Both)Surgery 10/01/2013 Prophylactic Ovary Removal (Both)
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Dec 3, 2012 12:43PM Nkb wrote:

Co418- the link does not work for me.

Dx 1/2012, ILC, Stage IIIc, Grade 2, ER+/PR+, HER2-Surgery 02/04/2012 Mastectomy (Both); Lymph Node Removal: Axillary Lymph Node Dissection (Both)Chemotherapy 02/28/2012 Adriamycin, Cytoxan, TaxolRadiation Therapy 09/11/2012 ExternalHormonal Therapy 10/22/2012 Arimidex
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Dec 3, 2012 03:19PM, edited Dec 3, 2012 03:21PM by cp418

http://www.medpagetoday.com/

Maybe try the home page link above - then under Specialties select Hemaology/ Oncology to find this article.

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Dec 3, 2012 07:12PM katylynn wrote:

Hey all!! I just started the trial last Friday. I've had no noticeable GI symptoms, but I have had pretty bad body aches towards the end of the day everyday since starting. Does anyone else experience this? So, I'm not sure if I have the placebo or Metformin...maybe I will notice something more when I bump up to two pills/day. I would like to have the real thing, especially since I'm only 31 with three young kids. However, either way I'm happy to help with the advancement of breast cancer treatment. After all, many women have done the same for me. Smile

Katy

Dx 3/7/2012, IDC, Stage II, Grade 3, ER-/PR-, HER2+Targeted Therapy HerceptinChemotherapy 03/22/2012 Adriamycin, Cytoxan, TaxolSurgery 09/06/2012 Mastectomy (Right); Lymph Node Removal: Axillary Lymph Node Dissection (Right); Prophylactic Mastectomy (Left)
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Dec 3, 2012 08:26PM MENA1954 wrote:

after reading about Medformin, I looked into it and I notices that in the NYC are 3 hospitals are involved in this trial and tha tmy Oncologist is in charge of all the studies.  I am looking forward to our appointment on the  December26  to discuss this trial with her.

How does it affect all the people that DO NOT have raised glucose levels?

Mena

Mena

Dx 6/25/2012, IDC, 1cm, Stage I, Grade 2, 0/3 nodes, ER+/PR+, HER2-Surgery 08/01/2012 Mastectomy (Both); Lymph Node Removal: Sentinel Lymph Node Dissection (Right); Prophylactic Mastectomy (Left); Reconstruction: DIEP flap (Both)Hormonal Therapy 09/20/2012 Arimidex
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Dec 3, 2012 09:21PM Outfield wrote:

Mena, there's a lot of experience prior to this trial for women with normal glucose levels because it has been prescribed quite a lot for women with polycystic ovarian syndrome.  Hypoglycemia is theoretically not a possible side effect of metformin because of how it works, but that's not so simple.  There are definitely women who have posted on this board who have had hypoglycemia.  I'm not sure how that's happening.  People prone to type II diabetes, who have insulin resistance, are often prone to hypoglycemia via pancreatic overshoot before they even develop diabetes.  But that doesn't explain why it would happen for the first time after taking a drug that should affect insulin levels in a direction toward normalization.

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Dec 4, 2012 08:31AM cp418 wrote:

Metformin May Improve Survival Rate Of Patients With Ovarian Cancer.

CBS News (12/4) reports on a study published online in the journal Cancer finding that metformin, "a common diabetes medication...may be used in the prevention or treatment of ovarian cancer." Explaining the study, "Dr. Elizabeth Poynor, a gynecologist and cancer specialist" appeared on "CBS This Morning." She said that while the study found "that women who had ovarian cancer who took Metformin for diabetes actually had a 20 percent better survival rate from the disease than women who did not take Metformin," yet "it's not yet known why this is the case." Poynor pointed out that a number of studies have looked "at Metformin with different cancers, such as prostate cancer, pancreas cancer, colon and breast cancer. It may have widespread implications to many different types of malignancies."

        HealthDay (12/4, Marcus) explains that metformin "is derived from French lilacs. It's typically prescribed to lower blood sugar levels in people with type 2 diabetes but has shown promise as a potential anticancer agent in recent prostate, colon, pancreas, brain and breast cancer studies, as well as in lab experiments with ovarian cancer cells." The study in question "evaluated the medical records of ovarian cancer patients who had received their cancer diagnosis between 1995 and 2010. Sixty-one patients were taking metformin at the time of their cancer diagnosis while 178 patients -- the control group -- weren't on the medication." It found that "67 percent of the women using metformin had not died within five years of their diagnosis, while only 47 percent of the control group had survived that long."

        MedPage Today (12/4, Fiore) reports that the study's authors concluded, "Metformin is worthy of clinical trials in ovarian cancer."

        WebMD (11/30, Boyles) reports, "The study is just one of dozens under way worldwide examining the drug -- which costs just pennies a pill -- as a treatment for breast, colon, prostate, pancreatic, and ovarian cancers."

        Fox News (12/3, Grush) reports on its website, "As for why the diabetes drug is so protective against cancer, the researchers cannot say for sure – but there are a few theories." One is that it "seems to inhibit the energy supply to the cell," and "may be acting on the cancer stem cells."

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Dec 4, 2012 08:39AM leggo wrote:

Don't know if you all know this, but a statin, combined with metformin, shows even more promise. Just thought I'd throw that out there for anyone, like me, who's not diabetic, but using metformin as a cancer treatment.

Dx IDC, 3cm, Stage IV, Grade 3, 26/35 nodes, mets, ER+/PR+, HER2+
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Dec 4, 2012 10:05AM cp418 wrote:

http://www.reuters.com/article/2012/11/07/us-statins-cancer-idUSBRE8A62H020121107

http://www.cbsnews.com/8301-204_162-57547177/statin-takers-less-likely-to-die-from-cancer-study-finds/

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Dec 4, 2012 07:32PM Nicole4 wrote:

Is Statin a cholesterol medicine?  I am on the trial without diabeties.  Maybe I should ask my doctor about this

thanks,

Dx 6/24/2011, IDC, 1cm, Stage IIIa, Grade 2, 11/18 nodes, ER+/PR-, HER2+Surgery Mastectomy (Left); Prophylactic Mastectomy (Left); Reconstruction: Tissue expander placement, Latissimus Dorsi flap (Right)Surgery 07/04/2011 Lumpectomy (Right)Surgery 08/04/2011 Lumpectomy (Right); Lymph Node Removal: Axillary Lymph Node Dissection (Right)Chemotherapy 09/20/2011 TaxotereTargeted Therapy 01/05/2012 HerceptinSurgery 03/09/2012 Mastectomy (Right)Radiation Therapy 04/24/2012 External
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Dec 4, 2012 07:59PM, edited Dec 4, 2012 08:05PM by IsThisForReal

Yes, statins are used for cholesterol.

Interesting links!

Lymphedema

Dx 11/30/2009, IDC, 2cm, Stage IIb, Grade 2, 2/12 nodes, ER+/PR+, HER2+Surgery 12/30/2009 Lumpectomy (Left); Lymph Node Removal: Axillary Lymph Node Dissection (Left)Chemotherapy 03/17/2010 carboplatin, TaxotereTargeted Therapy 03/17/2010 HerceptinHormonal Therapy 08/03/2010 TamoxifenRadiation Therapy 08/03/2010 ExternalSurgery 08/24/2011 Prophylactic Mastectomy (Both)Surgery 10/01/2013 Prophylactic Ovary Removal (Both)
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Dec 4, 2012 09:55PM purple32 wrote:

gracie1

Do you have  a med resource link ?

THX

Lymphedema on LEFT. NO radiation. 2 clean nodes. purple32. Hope is our light ... in the night.

Dx 3/2012, IDC, <1cm, Stage I, Grade 1, 0/2 nodes, ER+/PR+, HER2-Surgery 05/01/2012 Lumpectomy (Left)
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Dec 4, 2012 09:57PM purple32 wrote:

katylynn

Wait until you are at a higher dosage. I have the real deal heer and bloating etc .. very real.  That is all I notice.  (GI symptoms)

Good Luck.

Lymphedema on LEFT. NO radiation. 2 clean nodes. purple32. Hope is our light ... in the night.

Dx 3/2012, IDC, <1cm, Stage I, Grade 1, 0/2 nodes, ER+/PR+, HER2-Surgery 05/01/2012 Lumpectomy (Left)
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Dec 5, 2012 09:05AM leggo wrote:

Purple32, no I don't have a link. I got the information from my MD. cp418 provided a couple of links about the benefits of statins above. 

Dx IDC, 3cm, Stage IV, Grade 3, 26/35 nodes, mets, ER+/PR+, HER2+
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Dec 5, 2012 07:52PM kks_rd wrote:

The study about metformin and ovarian cancer sounds very promising. I'm a bit of a numbers geek.. the P-value made me actually say OMG out loud!

Thanks to the person who posted about bloating, etc. I have never had major GI symptoms but over the past year have had more discomfort/ gas/ bloating. I thought it was part of my "new normal" post-chemo but maybe not!!

~Kat~ Neoadjuvant DD AC x4, T x4; PFC 9/15/11. Partial mx & SNB 10/18/11; reexcised 11/15/11. Rads x30 whole breast, x8 boosts; DONE 2/14/12. Metformin clinical trial 'til 12/2016.

Dx 4/29/2011, IDC, 4cm, Stage II, Grade 2, ER-/PR-, HER2-
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Dec 7, 2012 04:41PM purple32 wrote:

thanks gracie

Lymphedema on LEFT. NO radiation. 2 clean nodes. purple32. Hope is our light ... in the night.

Dx 3/2012, IDC, <1cm, Stage I, Grade 1, 0/2 nodes, ER+/PR+, HER2-Surgery 05/01/2012 Lumpectomy (Left)
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Dec 14, 2012 06:51AM cp418 wrote:

http://www.medpagetoday.com/MeetingCoverage/SABCS/36442

Metformin Role in Breast Cancer Still Unclear

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Dec 14, 2012 06:52AM cp418 wrote:

http://www.medpagetoday.com/HematologyOncology/BreastCancer/36439

First Breast Cancer, Then Diabetes?

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Dec 14, 2012 08:31AM Maggs09 wrote:

Thank you for sharing above articles.
I'm about to start Metformin "off label" upon approval from my onc.
I already filled Rx, but waiting a couple of weeks as I just started Tamoxifen. My onc suggested to start with Tamoxifen first, see how I'm handling SE, and few weeks later - add Metformin.
I'm also doing rads, today will be #3.
How often do you get your blood checked when on trial?

Dx 5/14/2012, ILC, 6cm+, Stage IIIc, Grade 2, 16/18 nodes, ER+/PR+, HER2-Surgery 05/02/2012 Lumpectomy (Right)Surgery 06/27/2012 Mastectomy (Right); Lymph Node Removal: Axillary Lymph Node Dissection (Right)Chemotherapy 08/01/2012 Adriamycin, Cytoxan, TaxolRadiation Therapy 12/12/2012 ExternalHormonal Therapy 12/28/2012 Tamoxifen
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Dec 14, 2012 07:12PM Ossa wrote:

maggs I get my blood checked every six months

Today is the first day of the rest of your life.... NED Nov 2011

Dx 4/7/2011, IDC, 6cm+, Grade 3, 3/7 nodes, ER+/PR-, HER2+Chemotherapy 05/19/2011 Adriamycin, CytoxanTargeted Therapy 08/11/2011 HerceptinChemotherapy 08/11/2011 TaxotereSurgery 11/22/2011 Mastectomy (Right); Lymph Node Removal (Right); Reconstruction: Tissue expander placement (Right)Hormonal Therapy 12/28/2011 TamoxifenRadiation Therapy 01/27/2012 ExternalSurgery 05/11/2012 Reconstruction: Breast implants (permanent) (Right)Surgery 10/26/2012 Reconstruction: Nipple reconstruction (Right)
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Dec 15, 2012 05:30PM Maggs09 wrote:

Ossa, do you remember what are they checking?
My dr wants me to do blood work in a month and then another in 3 months....
Can't remember what tests....

Dx 5/14/2012, ILC, 6cm+, Stage IIIc, Grade 2, 16/18 nodes, ER+/PR+, HER2-Surgery 05/02/2012 Lumpectomy (Right)Surgery 06/27/2012 Mastectomy (Right); Lymph Node Removal: Axillary Lymph Node Dissection (Right)Chemotherapy 08/01/2012 Adriamycin, Cytoxan, TaxolRadiation Therapy 12/12/2012 ExternalHormonal Therapy 12/28/2012 Tamoxifen
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Dec 15, 2012 07:24PM Ossa wrote:

maggs.. not sure what they all check for(chemo brain).. They take about 10 viles (some very small) Have to be fasting so at least one will be for vloodsugars

Today is the first day of the rest of your life.... NED Nov 2011

Dx 4/7/2011, IDC, 6cm+, Grade 3, 3/7 nodes, ER+/PR-, HER2+Chemotherapy 05/19/2011 Adriamycin, CytoxanTargeted Therapy 08/11/2011 HerceptinChemotherapy 08/11/2011 TaxotereSurgery 11/22/2011 Mastectomy (Right); Lymph Node Removal (Right); Reconstruction: Tissue expander placement (Right)Hormonal Therapy 12/28/2011 TamoxifenRadiation Therapy 01/27/2012 ExternalSurgery 05/11/2012 Reconstruction: Breast implants (permanent) (Right)Surgery 10/26/2012 Reconstruction: Nipple reconstruction (Right)
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Dec 17, 2012 12:37PM whaevah wrote:

I am starting in 10 days, had to do the pregnancy test today. How's that for a waste of time and money... LOL!

Dx 2/2012, IDC, 2cm, Stage IIa, Grade 3, 0/1 nodes, ER-/PR-, HER2-Chemotherapy Adriamycin, Cytoxan, Taxol
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Dec 17, 2012 01:38PM oaktownmom wrote:

Whaevah - that's so funny about the pregnancy test.  I had an oopherectomy about a month ago, and they insisited on doing a pregnancy test the morning of the surgery.  Even though I had been in chemically induced menopause for a year (from chemo, and then from monthly zoladex shots).  And my husband has had a vasectomy.

Dx 6/23/2011, IDC, Stage IIIa, 6/14 nodes, ER+/PR+, HER2-Surgery 07/12/2011 Mastectomy (Right); Lymph Node Removal: Axillary Lymph Node Dissection (Right); Prophylactic Mastectomy (Left)Chemotherapy 08/16/2011 Adriamycin, Cytoxan, TaxolHormonal Therapy 01/02/2012 TamoxifenRadiation Therapy 02/08/2012 ExternalSurgery 11/14/2012 Prophylactic Ovary Removal (Both)Hormonal Therapy 01/02/2013 Femara

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