Log in to post a reply
Aug 26, 2008 12:26AM, edited Aug 26, 2008 12:30AM
OK, I found it!
The FOX News piece was similar to others appearing in other news reports in the past few days. All of them were highlighting a paper that was presented at the annual meeting of the American Chemical Society this past week. Some of the news reports, like one I saw on the CBS website, were based on an on-line article on WebMD that summarized the ACS paper. Here's a link to the WebMD article. I'll also include part of the WebMD the article: http://www.webmd.com/news/20080819/fruit-juices-block-common-drugs
Fruit Juices Block Common Drugs
Grapefruit, Orange, Apple Juices Decrease Absorption of Many Often-Used Drugs
Reviewed by Louise Chang, MD
Aug. 19, 2008 -- Grapefruit, orange, and apple juices block drugs commonly used to treat infections, allergy, transplant rejection, cancer, and high blood pressure.
In 1991, David G. Bailey, PhD, and colleagues found that grapefruit juice increased blood concentrations of the blood pressure drug Plendil to possibly dangerous levels. Grapefruit juice, they later learned, slows down a key liver enzyme that clears Plendil -- and about 40 other drugs -- from the body.
Now Bailey reports that grapefruit, orange, and apple juices decrease the absorption of several important medications:
- The allergy drug Allegra, available generically as fexofenadine
- The antibiotics ciprofloxacin (Cipro, Proquin), levofloxacin (Levaquin), and itraconazole (Sporanox)
- The beta-blocker blood pressure drugs atenolol (Tenormin), celiprolol, and talinolol
- The transplant-rejection drug cyclosporine (Gengraf, Neoral)
- The cancer chemotherapy etoposide (Toposar, Vepesid)
"This is just the tip of the iceberg. I'm sure we'll find more and more drugs that are affected this way," Bailey says in a news release.
Bailey revealed the new findings in a report to the 236th annual meeting of the American Chemical Society.
A substance in grapefruit juice called naringin seems to be the culprit. The compound apparently blocks OATP1A2, a transporter molecule in the gut, which carries some drugs from the small intestine into the blood. Orange juice contains hesperidin, a naringin-like substance. The culprit in apple juice remains unidentified. ...
People should take their pills only with water, advises Bailey, a professor of clinical pharmacology at the University of Western Ontario, London, Canada. ...
There have been lots of other news reports about the American Chemical Society paper. One of them, from www.dailymail.co.uk, included this statement:
"Professor Bailey said: 'Juice taken four hours prior to drug intake did not have an effect. Thus, it should be possible still to take grapefruit, orange and apple juices while on affected medications provided there is a sufficient time interval.' "
One thing we need to keep in mind is that the information about the effect of orange juice (and apple and grapefruit juices) on absorption of drugs from the intestine has not been published in a peer-reviewed research journal yet. That's the gold standard for communication of research findings. Simply presenting a report at a meeting does not give it the same level of credibility as having it evaluated thoroughly by experts in that area of study, and getting it published in a journal that is read by thousands of other scientists.
We should expect to hear more about this issue, though. In the meantime, it probably is a good idea to take our drugs with a glass of water, rather than O.J. Good find, Catherine!
Dx IDC, Stage I, Grade 2, 0/3 nodes, ER+/PR-, HER2-