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Nov 20, 2007 04:26 PM, edited May 2, 2008 08:09 PM
Toto, I just wish to give a literature citation which may offer further encouragement to the dear words above. In it, it lists chemotherapies active against liver cancer, and discusses arterial liver chemoinfusion as well as cytokines (immune modulators) and hormones. I know your marker is ER+, and understand that many times, but not always, a metastasis carries the same markers. It is particularly important, if possible to retest the marker status by biopsy, to see if it is the same, and to test for HER status, as something like 20% of recurrences will be HER+ even though initial tumor was HER-. This is quite phenomenal, imho, and allows tumor antibody directed Herceptin treatment.
Here is the title: "Multiple Liver Metastases of Breast Cancer: Report of a Case Successfully Treated with Hormone-Cytokine-Chemotherapy"
Quote from article: "In recent years, therapeutic strategies after relapse of breast cancer have gradually changed. Since 1982, endocrine chemotherapy has been systematically used. In chemotherapy for recurrent breast cancer, the efficacy of adriamycin (ADM), methotrexate (MTX), 5-fluorouracil (5FU), cyclophosphamide (CPM), vincristine (VCR) and mitomycin C (MMC) has been demonstrated. Antitumor cytokines such as TNF-[alpha] and IFN-[alpha] have also been used in clinical practice. We previously reported that TNF-[alpha] and IFN-[alpha] exhibited synergistic antitumor effects on human-derived malignant tumor in vitro and in vivo. By analyzing the cellular cycle, we clarified that the mechanism involved S-phase accumulation and S to G2/M block (12-14). Furthermore, we performed combination cytokine-chemotherapy with TNF-[alpha], IFN-[alpha] and anticancer agents including 5-FU by applying actions that are synchronous with the S phase (15). In our patient, the possibility that inhibitory effects on the tumor were enhanced by combining endocrine chemotherapy with cytokines cannot be denied".
This was a long time ago for this patient (1987) and yet they were successful in treating her liver. Since then, even more progress has been made. So, you are right to push now, and explore for your best possible care, and just so you know we'll be right there, pushing with and alongside of you...
All the best to you Toto,
IDC, Stage II, Grade 2, ER/PR+, HER-