Topic: TDM1 Trials: Anyone? Anyone?

Apr 7, 2009 12:57 PM radiant wrote:

Thanks BEYOND for keeping us up to date w/your journey through the TDM1 trial. Us Her2+++ gals really, really appreciate it.

- Kim

Apr 7, 2009 01:30 PM bmdaley wrote:

Wow, thanks for all the updates from the ladies on this important clinical trial. This is so encouraging! Am happy to hear you are feeling better too young :)

Apr 7, 2009 08:04 PM fightinhrd123 wrote:

Thanks for posting this,  I just found it, its really exciting to see the new drugs emerging.

Laura

Apr 8, 2009 01:37 PM mthomp2020 wrote:

I'm hoping this will become available quickly.  I seem to be prone to neuropathy, so there aren't really all that many drugs out there that don't cause it.  This gives me another tx that won't damage my nerves further.

Apr 14, 2009 09:09 AM Catgo wrote:

Ask your wife's Doctor...if you don't get a satisfactory answer call Breast Cancer Research centers, don't stop until you get all your questions answered.  I do know that they have just recently opened up this study to allow for more patients.

Apr 25, 2009 10:29 PM Irina wrote:

I'm so happy for you, you are better with this than with chemo

PRAYERS and (((HUGS)))

Apr 29, 2009 08:07 PM Catgo wrote:

My 2.7cm liver lesion is only .06cm on this drug after only 5 treatments. My Doc told me today that she just got back from Germany where there was a conference about this "miracle drug," as they are calling it around the world. She expects that trials will be opening everywhere very soon.

Apr 29, 2009 09:52 PM TenderIsOurMight wrote:

Too Young,

I checked for an update earlier today here, and so now I read your words. I'm sorry you are so fatigued, yet heartened by the skin's improvement. I wish you continued strength in tolerating this medicine. Newer thoughts on cancer fatigue sometimes include discussion of Ritalin or other stimulants to counter the great fatigue which accompanies some chemotherapy. I hope your blood count is normal, and you are not low in thyroid, being simpler causes of tiredness.

May all you ladies find continued success in this trial, and hopefully feel our support as you walk this challenging journey.

My best to you all,

Tender 

Apr 30, 2009 08:43 AM runtolive wrote:

hazel fox..  call your oncology office today..  ask them if they have this trial.. tdm1.. 

if not.. ask them to research and find it in your area.  california has many sites.

  <table><tbody><tr><td>United States, California</td></tr><tr><td>Cancer Care Associates</td><td>Recruiting</td></tr><tr><td>Redondo Beach, California, United States, 90277 </td></tr><tr><td>Contact: Sherry Hutcherson     310-750-3376     mailto:shutcherson%40mednet.ucla.edu?subject=NCT00679341, TDM4450g, A Study of the Efficacy and Safety of Trastuzumab-Mcc-DM1 vs. Trastuzumab (Herceptin®) and Docetaxel (Taxotere®) in Patients With Metastatic HER2-Positive Breast Cancer Who Have Not Received Prior Chemotherapy for Metastatic Disease     </td></tr><tr><td>Central Coast Medical Oncology</td><td>Recruiting</td></tr><tr><td>Santa Maria, California, United States, 93454 </td></tr><tr><td>Contact: Alison Fernandez     805-739-3724     mailto:alison.fernandez%40chw.edu?subject=NCT00679341, TDM4450g, A Study of the Efficacy and Safety of Trastuzumab-Mcc-DM1 vs. Trastuzumab (Herceptin®) and Docetaxel (Taxotere®) in Patients With Metastatic HER2-Positive Breast Cancer Who Have Not Received Prior Chemotherapy for Metastatic Disease     </td></tr><tr><td>Comprehensive Cancer Center</td><td>Recruiting</td></tr><tr><td>Palm Springs, California, United States, 92262 </td></tr><tr><td>Contact: Claudia Fortiche     760-416-4736     mailto:cfortiche%40aptiumoncology.com?subject=NCT00679341, TDM4450g, A Study of the Efficacy and Safety of Trastuzumab-Mcc-DM1 vs. Trastuzumab (Herceptin®) and Docetaxel (Taxotere®) in Patients With Metastatic HER2-Positive Breast Cancer Who Have Not Received Prior Chemotherapy for Metastatic Disease     </td></tr><tr><td>North Valley Hem Onc Med Grp</td><td>Recruiting</td></tr><tr><td>Northridge, California, United States, 91325 </td></tr><tr><td>Contact: Pamela Riach     818-885-8500 ext 2832     mailto:priach%40mednet.ucla.edu?subject=NCT00679341, TDM4450g, A Study of the Efficacy and Safety of Trastuzumab-Mcc-DM1 vs. Trastuzumab (Herceptin®) and Docetaxel (Taxotere®) in Patients With Metastatic HER2-Positive Breast Cancer Who Have Not Received Prior Chemotherapy for Metastatic Disease     </td></tr></tbody></table>

May 2, 2009 11:05 PM runtolive wrote:

www.ksdk.com/news/local/story....

May 29, 2009 11:08 AM mthomp2020 wrote:

I do hope they loosen the requirements.  The practice I go to is participating, but that particular trial requires that you have already had Tykerb/Xeloda, which I haven't.  With most available chemotherapies causing neuropathy, I'm going to run out of options pretty fast.  Navelbine worsened my numbness, and I don't want it to ruin QOL for me, which it very well could.  TDM1 would be a godsend for me. 

May 29, 2009 03:52 PM runtolive wrote:

roche/dna will be reporting results in the next few days at ASCO..  TDM1 will be featured in a BEST OF ASCO.. presentation.. 

2young..  which trial are you participating in..  the phase 2 trial that just completed enrollment. for patients who have already taken tykerb..  or a different tdm1 trial.  

Jun 11, 2009 11:20 AM tooyoungtohavebc wrote:

I just had my 5th infusion. Also got results of CT which still show stable overall although doc says he sees small improvements and def no new lesions. I know that is good in the cancer world, but I just want them to say...IT IS ALL GONE!!

So I will continue on the drug. Still tired as dirt and vision getting worse. May have to quit working for a while at some point.

Ok will post again when have something new to tell

Jul 30, 2009 01:37 PM tooyoungtohavebc wrote:

Hi Kim,

Still plugging along in this trial. Scans I had last week still show stable so seems to be keeping things in check. Skin mets have not gone away completely but are a bit smaller which is good because they were growing like mad for a while there.

Side effects are bout the same. lots of fatigue. Had to increase my contact prescription as my vision continues to get worse. Still have tummy issues and some back pain, but def better than when I started. Am taking some time off of work to help lower my stress levels and hopefully build up some energy.

Not sure if this trial is available in Canada. Good luck with the Herceptin...it has helped a lot of women!

Sep 3, 2009 11:54 AM tooyoungtohavebc wrote:

Hey everyone,

Been a bit since I updated. Good news is that my scans show that I am stable. I know it is better than progression, but oh how I wish for NED!

Still have lots of fatigue (I yawn a ridiculous amount of times daily)...my eyes seem to be even more irritated and I swear most of these drugs make me an emotional mess. I cry at like anything now and that is so not me...annoying. Also think this one (similar to when I took Tamoxifen and did not want to get out of bed) causes some depression. I didnt really have this when I did xeloda/tykerb and just herceptin so I know it is directly related to this drug. Also continue to have stomach issues, feet probs with both tingling and my skin.

Anyone else enrolled in this trial in other areas of the US? I think they closed this phase of the study recently and they just told me yesterday that instead of being limited to 17 cycles of the drug, that I can continue to have the treatment as long as it continues to work for me. Sounds like it might be getting closer to being moved to review to be approved.