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Mar 11, 2011 05:31am EnglishMajor wrote:
I recall that I had a hight proliferation rate but my dr. said it wouldn't guide treament choice. I think some of this info is used more for someone who has an early stage cancer to maybe give an idea of recurrence odds.
I also think you have to look at what's happened to you over the year of your treatment. If your cancer was super aggressive your experience would probably reflect that.
Here's an explanation of how the scoring works. (Sounds like figure skating!)
Histological grade is reported using the "Bloom Richardson Scale" or "Nottingham Score". It is a combination of nuclear grade, mitotic rate, and tubule formation, which are characteristics of the tumor cells seen under a microscope that predict its aggressiveness. Now, this scoring system is very detailed and usually does not affect treatment decisions, so it is not particularly helpful in the big picture. However, you will see it on the report and may be interested in what it means. In general, high grade tumors are more likely to recur when compared to low grade tumors.
* Nuclear Grade: a score is given from 1 to 3, based on the appearance of the nucleus of the cancer cells, with 1 being the closest to normal cells (better), 3 being the most variation (worse).
* Mitotic Rate: describes how quickly the cancer cells are multiplying or dividing using a 1 to 3 scale, 1 being the slowest, 3 the most rapid.
* Tubule formation: this score represents the percent of cancer cells that are in tubule formation. A score of 1 means greater than 75% of cells are in tubule formation (better), a score of 3 is used when less than 10% of cells are in tubule formation (worse), a score of 2 is in between 10 and 75%.
The three scores are then combined for a total score between 3 (1+1+1) and 9 (3+3+3). This score translates to a histological grade. You may see the three values and total score or just the final grade.
* Score of 3,4 or 5: Well differentiated or low grade (Grade 1)
* Score of 6 or 7: Moderately differentiated or intermediate grade (Grade 2)
* Score of 8 or 9: Poorly differentiated or high grade (Grade 3)
Dx 7/6/2009, IDC, 3cm, Stage IV, Grade 3, mets, ER+/PR+, HER2-