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Topic: WHY does Herceptin make joints hurt?

Forum: HER2/neu Positive Breast Cancer — Testing, Herceptin (trastuzumab) treatment, side effects, and more.

Posted on: Nov 1, 2009 07:23AM

moonwolf wrote:

What is Herceptin doing to make joints painful?  It can't be the bones themselves that are painful, so does it affect muscles or nerves?

Some people say it lowers oestrogen, but others say it does not!

It feels like arthritis to me, but it can't be because that's about wear and tear isn't it.  So that can't be the case in all the joints suddenly, since Herceptin.  My knees were a bit painful before Herceptin. I only need to do very little physically and my knees, thumb joints, wrists, shoulder and back get pretty painful.

I do wonder if it does permanent damage.

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Nov 1, 2009 08:24AM Brenda_R wrote:

I don't know but I had lots of pain in my hip joints, low back and legs the whole time I was on Herceptin. I asked my onc and he said he hadn't heard that H causes that.  I think I did finally read at the Genentech website that muscle pain can be a side effect of Herceptin. It has got better,although it's taken some time to improve.

Dx 12/12/2006, IDC, 3cm, Stage IIIa, Grade 3, 1/17 nodes, ER-/PR-, HER2+Surgery 12/29/2006 Lumpectomy (Right); Lymph Node Removal: Axillary Lymph Node Dissection (Right)Chemotherapy 01/28/2007 Adriamycin, CytoxanRadiation Therapy 05/01/2007 ExternalTargeted Therapy 07/10/2007 Herceptin
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Nov 15, 2009 07:30AM moonwolf wrote:

Thanks Brenda - My Onc actually admitted that Herceptin could cause joint pain and she is up there with the rest in denying SE's.  My neck aches like mad so that could be muscle pain from Herceptin and then that in turn could be causing my bad heachache, I guess.  I will look at Genentech - thanks.

 Did you take anything for the pain?

Dx 6/2008, IDC, 1cm, Stage II, Grade 3, 2/17 nodes, ER+/PR-, HER2+
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Nov 16, 2009 09:44PM NJLinda wrote:

When I had the Herceptin two years ago, a couple days after the infusion I would have pain in my knees and legs but it only lasted about a day and then I was fine until the next treatment!

Linda

Dx 6/8/2006, DCIS, 3cm, 0/21 nodes, HER2+
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Nov 16, 2009 10:37PM ktr3 wrote:

Hi

So that is why my body aches?   I wonder how long after you finish Herceptin does it take for the body to stop aching???

I had my last herceptin infusion in August and I still have days where I am very sore.

Thanks for any information sumitted. 

Dx 6/7/2005, IDC, 1cm, Stage II, Grade 2, HER2+
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Nov 16, 2009 10:40PM swimangel72 wrote:

Are you taking any AI's? I'm on Arimidex - and it's known for causing joint pain. I had Herceptin every two weeks for a year, but didn't notice any increase in joint pain........fingernails were ruined but that was about it. Hope you feel better soon.

3/3/08 Right-side mastectomy with immediate muscle-sparing free tram; 3/9/08 Developed abdominal MRSA staph infection and hernia;Completed 4 months Navelbine and 1 year Herceptin; Arimidex - 3 more years! Diagnosed at age 53

Dx 2/5/2008, IDC, <1cm, Stage Ib, Grade 1, 0/7 nodes, ER+/PR+, HER2+
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Nov 17, 2009 09:20AM Brenda_R wrote:

I took vicodin for pain. I have been taking a NSAID for inflammation for about 5 years, and we couldn't add any more to that, so just the vicodin.

No AIs.

Dx 12/12/2006, IDC, 3cm, Stage IIIa, Grade 3, 1/17 nodes, ER-/PR-, HER2+Surgery 12/29/2006 Lumpectomy (Right); Lymph Node Removal: Axillary Lymph Node Dissection (Right)Chemotherapy 01/28/2007 Adriamycin, CytoxanRadiation Therapy 05/01/2007 ExternalTargeted Therapy 07/10/2007 Herceptin
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Nov 18, 2009 03:25PM Dolores wrote:

 I'm on Herceptin and my knees hurt a lot too. I use Tiger Balm and it helps stop the pain.

genise greene

Dx 11/20/2008, IDC, 4cm, Stage IIa, Grade 3, 1/10 nodes, mets, PR-, HER2+