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Topic: Chance of recurrence small node neg her2+ treated with herceptin

Forum: HER2/neu Positive Breast Cancer — Testing, Herceptin (trastuzumab) treatment, side effects, and more.

Posted on: Jan 17, 2011 05:30PM, edited Jan 17, 2011 05:44PM by sylwiamolik

sylwiamolik wrote:

You should look at these trials:

http://www.asco.org/ascov2/Meetings/Abstracts?&vmview=abst_detail_view&confID=70&abstractID=40480

 http://jco.ascopubs.org/content/28/28/e541

It looks like herceptin and chemo decreses the chance of recurrence to zero :)

(First link doesn't work, copy and paste it) 

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Jan 25, 2011 07:49AM Rubyluby wrote:

sylwiamolik, I just want to say that your post made my day! I didnt know about these studies. However small and early they may be, they are a first stab at answering the question of how much difference Herceptin makes for really small node neg tumors. Every time I think of that graph with the 100% no recurrence blue line, I smile!

 Blessings to you,

Lucy 

Dx 1/13/2009, IDC, <1cm, Stage I, Grade 3, 0/5 nodes, ER-/PR-, HER2+
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Jan 25, 2011 10:27PM bluedasher wrote:

I'm happy to see these results too. The DFS for lymph node negative with TCH in BCIRG 006 was around 10% and but the women there generally would have had larger tumors (about half 60% of the women had tumors larger than 2 cm but there was no data in the presentation for the size spread in the node negative women in the study). So guessed that maybe my recurrence risk would be about half of that or 5%.

Also about 23% of the HER2+ cancers with no chemo in the MD Anderson study of women with node negative tumors less than 1 cm had recurrences so chemo and Herceptin cutting that to a quarter or around 5 or 6% seemed a reasonable guess. 

If the small studies you linked to are correct, then it is so close to 0% and that's a wonderful thought. I wasn't worried before because even 5% is small - but 0 is better!

The whole world is a narrow bridge and the main thing is to not fear.

Dx 9/2008, IDC, <1cm, Stage Ib, Grade 2, 0/5 nodes, ER-/PR-, HER2+
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Jan 30, 2011 06:47PM weety wrote:

Wow, I sure hope this is true too!

Dx 7/17/2009, IDC, <1cm, Stage Ib, Grade 3, 0/1 nodes, ER+/PR-, HER2+Targeted Therapy HerceptinHormonal Therapy FemaraSurgery Mastectomy (Left)Radiation Therapy ExternalChemotherapy carboplatin, TaxotereSurgery 04/19/2010 Prophylactic Ovary Removal (Both)Surgery 04/10/2013 Prophylactic Mastectomy (Right)
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Mar 11, 2011 01:50PM cookie2009 wrote:

Hi, What  would be my recurrence rate then? I had stage 1, no nodes, ,2ml tumor and a mastecomy. No treatment, Can you tell me what is my recurrence rate?

Cookie

Cookie

Dx 5/5/2009, IDC, <1cm, Stage I, Grade 2, 0/4 nodes, ER-/PR-, HER2+
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Jun 20, 2011 01:08PM bluedasher wrote:

Bumping up for HES112

The whole world is a narrow bridge and the main thing is to not fear.

Dx 9/2008, IDC, <1cm, Stage Ib, Grade 2, 0/5 nodes, ER-/PR-, HER2+