Topic: TRIPLE POSITIVE GROUP

Aug 7, 2012 06:50 AM lago wrote:

Soltantino my onc told another patient I know who is HER2+ but ER-/PR- that her risk was the highest in the first 3 years. If she was going to recur it would  most likely be during that time.

Triple positive risk is also highest in the first 3 years. I think for anyone who is ER+/PR+ regardless of HER2+ status the first 5 is the most likely. I have also read that distant recurrence (time wise) tends to be more common in lower grade. So basically us grade 3 (and maybe grade 2) if we recur it's usually earlier than later. No guarantees though.

I would be interested in what your onc says.

BTW I too have read many times about the initial testing of Herceptin in patients with mets without chemo. The goal (Dr. Slamon) of herceptin initially was to replace chemo. 

Aug 7, 2012 07:07 AM Omaz wrote:

Aug 7, 2012 07:49 AM AlaskaAngel wrote:

It is hard to keep in mind the difference between mets patients and earlier stage patients, but doing trastuzumab alone with early stage is quite a different matter.

The comparison of use of trastuzumab for chemo-naive newly diagnosed patients with stage IV is subject to the rather significant limitation that by the time mets are established, the tumor burden is much greater than it is for those without mets.

That is a far cry from having the intact immune system deal with the far less significant tumor burden (excised, not still in place such as with mets) of earlier stage bc, through the use of trastuzumab alone.

Aug 7, 2012 08:53 AM lago wrote:

Moni is that 35% because you couldn't do all the treatment?

Aug 7, 2012 09:09 AM moni731 wrote:

Soltantio- My uncle was 62 when he died. And yes, he was angry about it. He was a biologist and was wary of this before he was exposed.

Also, I have residual diet issues. I have been forced to become (kicking and screaming) a vegan-ish person! No dairy, meat, gluten! I was so not into this type of diet before! I guess it is better, but I really hate it.

Aug 7, 2012 09:52 AM TonLee wrote:

Here is what the general internet sources say...

Capsule formation around a breast implant begins in the first few weeks after placement of the implant. By about 2 to 3 months, the capsule formation has completed, but continues to mature and remodel for several months following. A contracture occurs when the scar tissue begins to constrict around the implant causing distortion in the implant which may be visible, palpable, or both.

Aug 7, 2012 11:07 AM scottie52 wrote:

TonLee: Don't do a lot of tequila; my elixir was (is) a Rusty Nail! That's scotch and drambuie, or as I like to say "scotch and scotch".
Just spent last 2 hrs catching up on all the posts I've missed. I have always lived and worked in high pressure, stressful situations and don't see that changing any time soon. And with the BRCA2+, er/pr+, her2+, guess I was a disaster just waiting to happen!
But life goes on and we take it one day at a time!

Aug 7, 2012 11:20 AM fluffqueen01 wrote:

i didn't wear the band, so can't help you there. I as allowed to go back to working out after a month. Started into it slowly and built up. I could walk all I wanted during that time.

moni-my friend's dad was the same and recently died of leukemia also. She gathered all the records and was able to prove that her dad was at the site, etc. The army just gave her mom $50,000 as settlement, and I think she is going to keep earning a monthly stipend.

Aug 7, 2012 11:30 AM jackboo09 wrote:

Lago, yes my tumour was 2.6cm at surgery. I had a mammo middle of March but how much reassurance can I gain from that? I will try and get an US tomorrow if I can persuade the docs! Have been in with similar worries before. Don't want to be neurotic but not letting it go either.
I've been working out too. Could that be why the scar is a little stretched/different. So tired. 3am now.
X

Aug 7, 2012 11:32 AM jackboo09 wrote:

It's at times like this that I begin to question having a lumpectomy and not a full mx

Aug 7, 2012 11:35 AM moni731 wrote:

Hi all! No, I had to stop the chemo. Only got 1 dose of AC and 1.5 doses of TCH, twelve of Herceptin before the MO said no more. We also tried Abraxane, not sure of that number, pretty out of it. Most everything else happened after the chemo attempt was done. The last 4 Herceptin doses were done in the hospital in a procedure called rapid-desensitization, to no avail. I hope that was enough. I am kind of leary telling people all of this as it would scare the beejeezes out of me. I have to emphasize that THIS IS NOT THE NORM. My MO said she only had one other case in 25 yrs of practice that this happened with and not nearly to my extreme. My immunologist brought my case before a convention board and no one else there had had this much trouble. My MO said I should consider a Mastectomy, but I cannot even be considered for reconstruction for being allergic to everything. I've lost enough at this point, not going there.

Aug 7, 2012 11:43 AM moni731 wrote:

Jackboo - Deep breath. Scars are funny things, and tend to change a lot. Being observant is all we can do. Let us know. Thoughts with you...

Aug 7, 2012 11:47 AM ArleneA wrote:

I agree Jackboo:  DEEP breath!  Try to get a few hours sleep and then see the onc tomorrow.  Do keep us posted!

Aug 7, 2012 11:51 AM jackboo09 wrote:

Thank you Arlene. Maybe some Benadryl will help. Thumping stress headache now. I hope to be in the position of feeling silly tomorrow if I'm given the all clear.

Aug 7, 2012 12:19 PM dancetrancer wrote:

Jackboo - I had a BMX and just had a small nodule evaluated last week (benign, thankfully) AND the doc found another nodule that I missed that now needs further follow-up.  So a BMX is not fool proof for not having post-tx scares - don't beat yourself up.  I know how scary this is - hugs to you - hoping you can get it checked out ASAP so you don't make yourself sick with worry.   My mantra I say to myself is "worrying isn't going to change the outcome".  That helps me refocus.