Topic: Pleomorphic LCIS and Research

Hi Omaha Girl

I was just about to post on the PLCIS thread to say I guess I am joining the club.  Yet again another club nobody wants to join.

Please count me in.  I will send you a PM

Thanks Cathy

Omahagirl I had a bilateral mastectomy as a result of extensive PLCIS. I could obtain slides/information from my doctors. PM me where to have the information sent.

Hi Linda!

Just back from New Orleans. Count me in! I've PM'ed you.

Eve

I spoke with the Dr. today and let her know that we had between 5 and 11 women who might be candidates for her study. She will tell the powers to be this and will be awaiting permission to start a study. I will let you all know as soon as I have an answer.

Hugs

Linda

Linda---could you please ask the doctor doing the study if she will be including any subjects with classic LCIS. Thanks

anne

Well, there's this opinion:

"The cells of classic LCIS, as described above, can also be referred to as type A cells. Type B cells are a well-recognised subtype of LCIS cells, with mildly to moderately larger nuclei showing some increase in pleomorphism. A more recently described entity is that of pleomorphic LCIS (PLCIS). The cells in this lesion show more marked pleomorphism and distinctly larger nuclei with nucleoli. Central necrosis and calcification within lobules are features of note. In a situation analogous to ALH versus LCIS, there might be some difficulty in terminology and practical differentiation between a case of LCIS with type B cells and that of PLCIS. Sneige and colleagues [15] have described type B cells as containing nuclei that are up to double the size of a lymphocyte (type A cells are 1–1.5 times larger), whereas PLCIS nuclei are typically four times larger. These subtypes might represent a spectrum of lesions, but it is possible that PLCIS has different biological behaviour and implications from those of classic LCIS. It is therefore important to recognise and document the presence of this variant." http://www.ncbi.nlm.nih.gov/pmc/articles/PMC314428/

I am new to this forum, since I just got my path report today after my lumpectomy (for diagnosed DCIS) and it reported both classic and pleomorphic LCIS (but no DCIS).  And yes, I would be interested in helping with a study.  I'm still trying to get a handle on where I go from here, so I'll probably be hanging around for awhile.

Hi Cornellalum

Sorry you have found yourself here, but you have come to a great place with lots of wonderful and very knowledgeable women.

It sounds like you have also been getting different diagnosis which I know can make this very confusing. But it does help to finally know what you are dealing with doesn't it. I have just recently been diagnosed with PLCIS from MRI guided biopsy and am waiting for the results from lumpectomy.  I am curious what your surgeon has given you for treatment options? In my case I was told they have to get clear margins and if they do, my next step would be radiation, which I am really nervous about. If they don't get clear margins, either a re-excision or mastectomy.

Take Care

Cathy

Hi Mary

Everything with the surgery seemed to go well as far as I know. Just a little sore now, but most anxious to get the pathology results, which won't be until November 30 unfortunately. So looks like I will be making yet another trip and back in the wait mode. ugh!!

Cathy