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All TopicsForum: IDC (Invasive Ductal Carcinoma) → Topic: Ki-67 95%

Topic: Ki-67 95%

Forum: IDC (Invasive Ductal Carcinoma) — Just diagnosed, in treatment, or finished treatment for IDC.

Posted on: Jul 23, 2009 08:29PM

buccaneersdj wrote:

The oncologist saying "Ki-67 is 95% wow, that is not good", keeps ringing in my head. And triple negative on top of that, help has anyone ever heard of this number being that high? I now feel like I will be riding my bike uphill, a really tall steep dirt hill and my chain just fell off! Is beating this even do-able??

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Jul 23, 2009 09:52PM LRM216 wrote:

Mine is high too - at 61%.  Onc didn't seem to bothered about it, as I am triple neg, and that makes my nodule more aggressive right from the get-go.  Your stats are good, so I wouldn't worry too much about it.  Just go as agressive as you can with the chemo.  Good luck and keep us posted.

Linda

Life isn't about waiting for the storm to end, it's about learning to dance in the rain ... Age 62 at diagnose

Dx 2/23/2009, IDC, 1cm, Stage I, Grade 3, 0/1 nodes, ER-/PR-, HER2-Surgery 03/07/2009 Lumpectomy (Right)Chemotherapy 04/25/2009 Adriamycin, Cytoxan, Taxol, TaxotereRadiation Therapy 10/21/2009 External
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Jul 23, 2009 10:42PM fightinhrd123 wrote:

Mine was high too, chemo loves to kill fast mutiplying cells, I had chemo first and not one cancer cell left, and i had at least 2 pos nodes, probably four, so i dont look at my ki67 being high as a bad thing :) 

Dx 5/29/2008, IDC, 2cm, Stage IIb, Grade 2, 2/14 nodes, ER-/PR-, HER2+
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Jul 24, 2009 11:33AM jdeking wrote:

I had a high Ki-67 also, in the 80's. Luckily chemo really zaps those rapidly proliferating cells, so look at it as being a good thing. Also, you were node negative, so it seems like your cancer was contained, which is also a good thing!

 Good luck to you, you can do this! We are warriors after all.

((((hugs)))))

Janine

Dx 1/6/2009, IDC, 1cm, Stage IIa, Grade 2, 2/10 nodes, ER+/PR+, HER2-
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Jul 24, 2009 11:46AM, edited Jul 24, 2009 11:49AM by lookingforward4more

I just want to say that its a great sign that your nodes were negative. I had Grade 2 and 1 cancer with Ki-67 of 3% and 5% (two tumors in right breast) and also had two positive nodes. My point in telling you this is simply that even with excellent "pathology" my cancer spread to the nodes and yours did not which is a GREAT thing! Keep thinking positive thoughts and fight hard now. Chemo works much better on higher Ki-67 from what I have learned so the medicine is going to help your treatment! You can have a full recovery!

Dx 11/13/2007, IDC, 3cm, Stage IIIa, Grade 2, 2/24 nodes, ER+/PR+, HER2-
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Jul 26, 2009 04:43PM, edited Jul 26, 2009 04:46PM by ajlive

This Post was deleted by ajlive.

Oncotype Score: 12. Radiation: 33 Treatments. HRT: Tamoxefin.

Dx 2/24/2009, IDC, 1cm, Stage I, Grade 1, 0/2 nodes, ER+/PR+, HER2-
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Jul 28, 2009 04:49PM EllenWeav wrote:

we may be twins....my Ki-67 is 98%....same thing, when my oncologist said "this is the fastest growing tumor I've ever seen"..didn't help me much considering he is now retired and a world reknown breast cancer specialist.....I too had no node involvemnet. I was dx Jan of 08...my new oncologist wants to do preventitive chemo again in 2 yrs...I am doing it, because chemo does work great against the aggresive cells....I am clean and clear right now....triple negative as well..would love to compare notes with any others who are triple negative.

 Hope & Friendship to ALL

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Aug 3, 2009 10:12AM Kate2z80 wrote:

Where do I find the info on Ki-67?  I haven't seen that on any of my reports.

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Aug 10, 2009 09:36AM thenewme wrote:

Yikes! I just looked at my path report and mine shows Ki-67 = 100% - is that even possible?  I'm triple negative too,and my tumor grew super fast (now I know why!)

Dx 11/2008, IDC, 5cm, Stage IIb, Grade 3, 0/9 nodes, ER-/PR-, HER2-
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Aug 12, 2009 07:49AM angelsabove wrote:

Wow...looked at mine and my ki-67 is 88%. They say chemo works best on the ones that divide the fastest. So I say that would mean the ball is in OUR court.....

May God Bless Us All

Dx 4/27/2009, IDC, 4cm, Stage IV, Grade 3, 3/13 nodes, ER-/PR-, HER2-
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Aug 27, 2009 11:06AM angelsabove wrote:

bump

Dx 4/27/2009, IDC, 4cm, Stage IV, Grade 3, 3/13 nodes, ER-/PR-, HER2-
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Aug 27, 2009 12:16PM roxy42 wrote:

Hi mine was high it was 80 and I'm 2 years out doing great no sighn of cancer.Kemo works great for high ki-67.........godbless roxy

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Aug 27, 2009 12:37PM weesa wrote:

My ki-67 was very high when I was diagnosed almost seven years ago. It was expressed as "two plus" on my path report. Yet my mitotic rate was only a "1". Never could understand if this is a contradiction. Onc never seemed concerned about ki-67, though. Just recently I had oncotypedx and it came back an 18. I am stage 3a grade 2, er, pr+ her-2 neg.  Had dd chemo, rads, mastx, AI's. Still Ned.

This brings me to another thought--since my joining here I have been struck by the number of members like myself, who don't understand their path report or who at least have some major questions about it. I have had stuff haunt me for years. I go to all the "Understanding your path report" type of websites and they are so general they don't give me any insight into mine. I would love to hear from anybody who really understands her path report and let me know how the heck you accomplished this. We seem to be a group of intelligent well informed women who are always on the prowl to learn more--yet this seems to be a common theme for us. Too bad--we shouldn't have to live with mysteries like this.Can't everything be reduced to lay terms? Would love to hear from you guys who share my frustration.

Sometimes I wonder if I am an old soul temporarily trapped in a breast cancer body.

Dx 11/22/2002, IDC, 6cm+, Stage IIIa, Grade 2, 5/25 nodes, ER+/PR+, HER2-Surgery Lumpectomy (Right); Mastectomy (Right); Lymph Node Removal: Sentinel Lymph Node Dissection, Axillary Lymph Node Dissection (Right); Reconstruction: Latissimus Dorsi flap (Right)Chemotherapy 01/20/2003 Adriamycin, Cytoxan, TaxotereRadiation Therapy 06/14/2003 ExternalHormonal Therapy 08/23/2003 Femara
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Aug 27, 2009 01:58PM connette wrote:

Weesa, I agree totally with you.  I have tried to understand my path report but my emotions always seem to get in my way.  I always feel that I am the only one with my stats.  I am er-/pr+, her2+.  In the time since I have joined, I have found only one other person with this dx. and she has not been on the boards lately.  I really admire those women that understand what is happening to their bodies.  I would love to have an idea what everything means.  Thank for posting what I have been thinking.  Connette

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Aug 29, 2009 09:10PM fairy49 wrote:

Weesa! isn't it so frustrating??!! It has taken me nearly a year to figure out my path report, to the point that I think I know it better than my onc! LOL!! I took every single thing on the path report and googled it until I found out what it meant, once I found out what it meant I continued to research to find out exactly what the score meant and so on, it was painful and scary, because I would get results, have no one to ask, and freak myself out! So now I know my path report inside out backwards, do I understand it totally, not yet, but am working on it! I stun my doctors with some on my questions, they give me this deer in the headlights look, I don't think they know that much about the total path report either, I think they have the certain things they look at, and thats that, so sad that we have to figure this all out ourselves!  The good thing is, that we can help others that come to this site looking for answers, hopefully....

L

ox

DX 9-22-08 IDC 1.1cm Stage 1 Grade 2 SNB 0/5 ER+ PR+ HER- Bi-Lat Mas re-con,tissue expanders on 10/29 - Exchange to silicone implants on 3/6/09 Oncotype DX Score 9 - BRCA 1 & 2 Negative.....If God brings you to it, he WILL get you through it

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Aug 29, 2009 09:26PM weesa wrote:

fairy49, you bet it's frustrating. I did exactly what you did,pulled each word out of my path report and googled the word until I thought I understood it.But in the context of my report it didn't always fit in. (It reminded me of going to france with my little english to french dictionary, and stringing words together one by one that made no sense to anybody.Everybody burst out laughing.) Anyway, I bet if we polled everybody there would be a lot of folks still pondering stuff. I think we all get the basics like er pr+ but some of the stuff like locations of glands and what does "no vascular invasion mean--don't tumors have to have blood supply to live?--I have a hunch a good many of us have clueless areas of their path reports.I'd love to hear from some of us who have got their path report licked, and no longer yank it out ot the desk drawer periodically to agonize over it.

Sometimes I wonder if I am an old soul temporarily trapped in a breast cancer body.

Dx 11/22/2002, IDC, 6cm+, Stage IIIa, Grade 2, 5/25 nodes, ER+/PR+, HER2-Surgery Lumpectomy (Right); Mastectomy (Right); Lymph Node Removal: Sentinel Lymph Node Dissection, Axillary Lymph Node Dissection (Right); Reconstruction: Latissimus Dorsi flap (Right)Chemotherapy 01/20/2003 Adriamycin, Cytoxan, TaxotereRadiation Therapy 06/14/2003 ExternalHormonal Therapy 08/23/2003 Femara
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Aug 30, 2009 02:34PM fairy49 wrote:

Weesa! you sound like me with the french thing LOL!! made sense to me! teehee!!

I have my path report in a file and its so worn out as I pull it out all the time! shish!! such a friggin pain in the ass to have to learn it all yourself, however, knowledge is power, so I am glad I have learned so much, but still so much to learn! I think I have the big stuff down, but I still pick it to pieces!

L

ox

DX 9-22-08 IDC 1.1cm Stage 1 Grade 2 SNB 0/5 ER+ PR+ HER- Bi-Lat Mas re-con,tissue expanders on 10/29 - Exchange to silicone implants on 3/6/09 Oncotype DX Score 9 - BRCA 1 & 2 Negative.....If God brings you to it, he WILL get you through it

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Aug 30, 2009 04:01PM JaniceRH wrote:

You know, no matter where I look, I cannot find Ki-67 on my path report!!  is it called something other than this? what does it pertain to?

Thanks!

Dx 7/30/2009, IDC, 1cm, Stage Ib, Grade 2, 0/1 nodes, ER+/PR+, HER2-
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Aug 30, 2009 04:04PM hrf wrote:

What is Ki-67?

I have never heard of it and don't know what it means.

BRCA2+ first dx in Oct. 2004 2nd dx Feb. 2009 a new primary

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Aug 31, 2009 11:07AM swest wrote:

I looked on my path report and cannot find my Ki-67 score.  I did find my knottingham score is this the same?

hrf - I think it tells you how agressive your caner is. 

Dx 10/22/2008, IDC, 2cm, Stage Ib, Grade 3, 0/3 nodes, ER-/PR-, HER2-
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Sep 1, 2009 04:46AM queenlurker wrote:

weeza, Agonized over my path report yesterday.  Seems like I can find something new everytime.

Found a pathology site which said that if a tumor was hormone neg to expect Ki-67 to be 50-90, good thing for me because mine was 87.

casey

Dx IDC, Stage IIa, Grade 3, 0/10 nodes, ER-/PR-, HER2-
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Sep 9, 2009 03:44AM Brenda_R wrote:

KI67 can also be called Mitotic rate.

Dx 12/12/2006, IDC, 3cm, Stage IIIa, Grade 3, 1/17 nodes, ER-/PR-, HER2+Surgery 12/29/2006 Lumpectomy (Right); Lymph Node Removal: Axillary Lymph Node Dissection (Right)Chemotherapy 01/28/2007 Adriamycin, CytoxanRadiation Therapy 05/01/2007 ExternalTargeted Therapy 07/10/2007 Herceptin
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Sep 20, 2009 05:41PM MsBliss wrote:

My ki67 was 90% on biopsy, 70% on lumpectomy, also triple negative.  My doctor felt that my tumor was only 6 to 12 months old, which is probably why I had neg nodes too.  Did your report say anything about medullary features?

Dx 3/09 Triple negative, stg1,SNB0/2, BRCA neg, 1.4cm plus 7mm DCIS, ki67 70-90%, lumpectomy w/re-excision, no chemo/no rads due to delays from secondary health issues; SonoCine every 6 months

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Sep 20, 2009 06:59PM MsBliss wrote:

A high ki67 is not necessarilly a bad thing--especially if you are doing chemo...it can actually work in your favor.  Also, the fact that your nodes were neg means that your tumor may look aggressive but actually behave better.

Dx 3/09 Triple negative, stg1,SNB0/2, BRCA neg, 1.4cm plus 7mm DCIS, ki67 70-90%, lumpectomy w/re-excision, no chemo/no rads due to delays from secondary health issues; SonoCine every 6 months

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Aug 27, 2013 11:04AM Jo6202 wrote:

My ki67 did not show a percentage that I could see as the oncologist turned the computer screen away from me because I asked him why the report said ki67 -unfavorable. I asked for a copy of the report and he said his printer wasn't working. I then wrote down what it said so I wouldn't forget how it was worded and onc Asked what I was writing and I told him. He then said I didn't need to write that down....REALLY? I am scheduled for surgery on Friday and maybe he didn't want to tell me until he has all the information before him but then just say so. Now I have trust issues with him and I'm thinking maybe I need to find a new onc before I start any treatment. Grrrrrrr.. My body, my reports, just be upfront with me or I will think the worst. Anyone else have trust issues?

Someday your life will pass before your eyes. Be sure it's worth watching.

Dx 8/8/2013, IDC, 2cm, Stage Ia, Grade 3, 0/1 nodes, ER+/PR+, HER2-Dx 8/30/2013, DCIS, <1cm, 0/1 nodesHormonal Therapy ArimidexSurgery 08/30/2013 Lymph Node Removal: Sentinel Lymph Node Dissection (Left)Surgery 08/30/2013 Lumpectomy (Left)Surgery 09/11/2013 Lumpectomy (Left)Radiation Therapy 10/28/2013 External
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Aug 27, 2013 10:50PM Cougarlicious wrote:

Mine is also 95%, and my radiologist said that there was another patient the day I got diagnosed that also had a 95%. Makes sense why my tumor grew half a centimeter in a week, from my tumor board visit to pre-op appointment...and why chemo was so important to begin straight away even though I am pregnant. Now I know it might work in my favor. :)

Diagnosed while 6 months pregnant...baby born 10/26 healthy with full head of hair despite three AC txs!

Dx 7/2013, IDC, 3cm, Stage II, Grade 3, ER+/PR-, HER2-Chemotherapy 08/18/2013 Adriamycin, Cytoxan, TaxolSurgery 02/26/2014 Mastectomy (Right); Prophylactic Mastectomy (Left); Reconstruction: Tissue expander placement (Both)
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Aug 27, 2013 11:21PM soriya123 wrote:

My Ki67 is 90, my BS told me I have bad tumor, I gues she just saying the truth. Not that what I want to hear.

Dx 6/17/2013, IDC, 2cm, Stage II, Grade 3, 0/2 nodes, ER-/PR-, HER2+Targeted Therapy 07/17/2013 HerceptinChemotherapy 07/17/2013 carboplatin, TaxotereSurgery 12/04/2013 Mastectomy (Right); Lymph Node Removal: Sentinel Lymph Node Dissection (Right)
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Aug 28, 2013 04:39AM Lily55 wrote:

Get a second pathology report done, mine was 95 percent time and 25 percent second time, i think a lot depends on which exact bit of tissue they assess

Dx 4/2012, ILC, 5cm, Stage IIIa, Grade 2, 7/14 nodes, ER+/PR+, HER2-Surgery 05/03/2012 Mastectomy (Right); Lymph Node Removal: Axillary Lymph Node Dissection (Right)Radiation Therapy 08/15/2012 ExternalHormonal Therapy 07/20/2013 Aromasin
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Aug 28, 2013 06:16AM doxie wrote:

I read somewhere that the initial needle biopsy may be more accurate than tissue taken later during surgery.  Increased Ki67 is related to cell repair, which occurs after the needle biopsy.  So a higher Ki67 found in tissue taken from the BC surgery may be inflated.  

Of course BC tumors are not homogenous tissue and one sample can vary from the other regardless of when taken.  

Dx 8/2011, IDC, 1cm, Stage I, Grade 2, 0/7 nodes, ER+/PR+, HER2-Hormonal Therapy AromasinChemotherapy Cytoxan, TaxotereRadiation Therapy ExternalSurgery 09/02/2011 Lumpectomy (Right)
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Sep 14, 2013 12:02PM AnnietheRealtor wrote:

I also had a high Ki-67, ER/PR+ though.  Tumor quadrupled in size in pre-op time.  So I had to have dose dense chemo before surgery.  It DID knock the tumor back significantly from 5cm to 2.5, but did not clean up all of the nodes.  6 of 22 positive. They got clean margins though.  I am one year clean and seem to be doing great.  AI's are hard.  My biggest question lies in the follow up.  One clean PET scan a year ago and that's it?   No more scans?  Blood tests?  Just a physical exam every three months?   IDC 2.5 cm Stage 3 Grade 3 6/22 nodes.

Dx 7/19/2011, IDC, 4cm, Stage IIIb, Grade 3, 6/22 nodes, ER+/PR+, HER2-Chemotherapy 08/08/2011 Adriamycin, CytoxanSurgery 12/12/2011 Mastectomy (Left); Lymph Node Removal: Axillary Lymph Node Dissection (Left)
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Sep 17, 2013 11:10PM pooka1978 wrote:

agreed.agreed.agreed Weesa. I just rang the bell today! Eight rounds of neoadjuvant, and a mast/immediate recon scheduled for 10-21-13. I was looking at my path report today becuase my ki-67, while low 31% in one tumor and 17% in another was never discussed with me and sort of dimsmissed by my onc. I didn't go through the red devil and horrid side effects for nothing. I believe the patient bill of right's should include an ammendment that patients should be offered a lay example/interpretation of all major medical reports (ie pathogy reports pertaint to cancers). I am a mammographer by education and training. I have had a lot of wonderful experiences with warriors. They had always be great to share new information that they were gleaning from the internet and other survivors. We are a smart, inquisitve crowd, with a thirst for understand this disease as it effects us. I think to start many off with a lay interpretation is a small service that would provide a postive foundation for correct research and understanding. It sure in the world would save precious hours on the computer digging to find certain testing methods and how they relate to the percentage obtained, and so forth. My time is precious and for some its limited. 

basically, I agree with you whole0heartedly :)

Mindy age 34. Mother to four outrageous, crazy, fun boys :)

Dx 5/17/2013, IDC, 4cm, Stage IIa, Grade 1, 0/5 nodes, ER+/PR+, HER2-Surgery 05/20/2013 Lymph Node Removal: Sentinel Lymph Node Dissection, Axillary Lymph Node Dissection (Right)Chemotherapy 06/11/2013 Adriamycin, Cytoxan, TaxolHormonal Therapy 10/08/2013 TamoxifenSurgery 10/21/2013 Mastectomy (Right); Reconstruction: DIEP flap (Right)

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