The_Husband

My wife had her 2nd Chemo today and was told she is HER2 negative. still not sure what this means, anyone help?

The Husband.

Can someone please tell me what the difference is, and what difference it makes to treatment?

Just to let you know we got a phone call today out of the blue to say my wife starts chemo(FEC)  next friday 16 may.

That was good Otter thank you.

Ok went to see the oncologist, not a lot to tell really, we are going to be starting chemo in around 3 to 4 weeks, they called it FEC. 6 rounds apparently followed by radiotherapy and hormone treatment, I asked about ER and was told my wife was

ER positive 7whatever that means, they said it was good?????

Hey Otter, I just had a look at that site about Nottingham Index,

Thanks .

Thank you so much,

 I now am geting to grips with this,

IDC Grade 3 Stage 2.

I will let everyone know how wednesday goes.

Thanks again.

Details

1. Left breast WLE standard orientation

2. Left auxillary node sampling(4+).

Macrosopy

1. Labelled left breat wide local excision.

Piece of breast tissue 65 x 38mm, depth 42mm with ellipse of skin 41 x 12mm on its surface. Weight 55 grams. The margins are marked with colored inks as follows: red=inferior, yellow=medial, green=superior, blue=lateral, black=deep.Slicing the specimen reveals a hard irregular tumour approximately 23mm in maximum dimension approaching to 10mm from the inferior margin, 15mm from the superior margin, 20mm from the lateral margin and 20mm from the medial margin.

Distance to deep margin 8mm.

Block 1 - tumour including inferior margin.

Blocks 2 & 3- tumour.

Block 4 - deep margin.

Block 5 - inferior margin.

Block 6 - Superior margin.

Block 7 - medial margin.

Block 8 - lateral margin.

2. Labelled left breast axillary node sampling.

Six pieces of fatty tissue between approximatley 8mm and 60mm in maximal dimension. Five probable lymph nodes each embedded separatley in blocks 9 to 13.

Microscopy

Invasive tumour --present

Grade 3 infiltrating ductal carcinoma - NST (3,2,3).

Maximum dimension of invasive tumour - 21

Vascular invasion - present

Margins of excision - clear.

Distance to nearest margins - deep = 7mm;all other margins>10mm.

In situ tumour -- present

Type -- Ductal carcinoma in-situ.

Nuclear grade -- intermediate.

Pattern -- solid, comedo and cribriform

Maximum dimension of whole tumour including DCIS 21mm.

Margins of excision - clear.

Distance to nearest margins - deep = 4mm; all other margins > 10mm.

Lymph nodes -- negative

Total number of lymph nodes - 5.

There is no evidence of metastatic tumourwithin lymph nodes.

Diagnosis: Left breast (WLE) ; Grade 3 infiltrating ductal carcinoma - NST

pT2, pNo. Nottingham prognostic index 4.42

Thanks Sue,

Well tomorrows the day,

And I must remember to ask for a copy of the pathology report,

will let you know.

My wife had surgery week last thursday, we have an appointment on friday morning to get the results,they also said that an appointment will be made then to see the oncologist, will the surgeon tell us what treatment we will have or will we have to wait until we see the oncologist?