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Topic: Tumor markers

Forum: Not Diagnosed With a Recurrence or Metastases but Concerned —

Meet others concerned about developing a recurrence or metastases.

Posted on: Dec 24, 2019 09:12AM

pesky904 wrote:

Wasn't sure where to put this, so I put it under this topic.

If your CA 15-3 and CA 27-29 increase but are still within normal limits, does that mean anything?

When I was diagnosed, mine were in normal limits, but on the higher end. Now I'm being evaluated for recurrence and they have both increased but still within normal limits and still lower than they were when I was first diagnosed in 2017.

Do these numbers fluctuate often?

​dx 6/17 stage III TNBC 6cm tumor Taxol 7-8/17 tumor grew to 10cm AC 9-10/17 tumor shrunk to 3cm DMX 11/17 expanders placed Rads 33 doses + cisplatin 1/18 Cisplatin discontinued due to SEs Xeloda 4-10/2018 Exch surgery 11/18
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Dec 24, 2019 11:48AM MinusTwo wrote:

Tumor markers are only an indication - not a diagnosis. Many docs won't even do the tests because they are just that - an indication - and only useful if change is watched over a period of time. If they continually go up over several tests, my MO said they might do other tests.

2/15/11 BMX-DCIS 2SNB clear-TEs; 9/15/11-410gummies; 3/20/13 recurrance-5.5cm,mets to lymphs, Stage IIIB IDC ER/PRneg,HER2+; TCH/Perjeta/Neulasta x6; ALND 9/24/13 1/18 nodes 4.5cm; AC chemo 10/30/13 x3; herceptin again; Rads Feb2014
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Dec 24, 2019 12:15PM pesky904 wrote:

Thank you for the reply. That’s exactly what I was asking. Mine have inched up just a very tiny bit with every repeated test. But I wasn’t sure if they fluctuate sort of the way a glucose level fluctuates

​dx 6/17 stage III TNBC 6cm tumor Taxol 7-8/17 tumor grew to 10cm AC 9-10/17 tumor shrunk to 3cm DMX 11/17 expanders placed Rads 33 doses + cisplatin 1/18 Cisplatin discontinued due to SEs Xeloda 4-10/2018 Exch surgery 11/18
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Dec 25, 2019 09:29AM illimae wrote:

Mine typically fluctuate between 12-19 and stay in range. As minus said, they’re only an indication. For some, they’re relevant and for others, they’re not. Symptoms and scans are what most docs consider actionable information.

Diagnosed at 41 Stage IV De Novo Dx 11/16/2016, IDC, Left, 5cm, Stage IV, metastasized to bone, Grade 3, 3/13 nodes, ER+/PR-, HER2+ (IHC) Targeted Therapy 1/1/2017 Perjeta (pertuzumab) Chemotherapy 1/2/2017 Abraxane (albumin-bound or nab-paclitaxel) Targeted Therapy 1/2/2017 Herceptin (trastuzumab) Surgery 6/26/2017 Lumpectomy: Left; Lymph node removal: Underarm/Axillary Radiation Therapy 8/10/2017 Breast, Lymph nodes Dx 10/5/2017, IDC, Left, Stage IV, metastasized to brain Radiation Therapy 10/19/2017 External: Brain Radiation Therapy 4/18/2018 External: Brain Radiation Therapy 5/23/2019 External: Brain Hormonal Therapy Tamoxifen pills (Nolvadex, Apo-Tamox, Tamofen, Tamone)
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Dec 25, 2019 10:20AM Tinkerbell107 wrote:

Minus2: Agree. My MO won't even order the tumor marker labs based on their unreliability. Plus I was informed it may exacerbate emotional distress which in several cases the MO feels is unwarranted. My monitoring is what Illimae just noted symptims and scans. For now I'm totally ok with this approach...

Dx 8/23/2019, IDC, Left, 2cm, Stage IV, metastasized to bone, Grade 3, 5/6 nodes, ER+/PR+, HER2-
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Dec 29, 2019 11:50AM pesky904 wrote:

Thanks for the replies! I know these markers aren’t very reliable.

When I was first diagnosed, my tumor was over 7 cm and my CA 27-29 was only 30 (normal range is 0 - 38).

Because of that, I’m also aware that a normal range isn’t an indication of anything. I was just wondering how often the numbers fluctuate.

​dx 6/17 stage III TNBC 6cm tumor Taxol 7-8/17 tumor grew to 10cm AC 9-10/17 tumor shrunk to 3cm DMX 11/17 expanders placed Rads 33 doses + cisplatin 1/18 Cisplatin discontinued due to SEs Xeloda 4-10/2018 Exch surgery 11/18
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Jan 7, 2020 04:22PM HeatherPsalm34-4 wrote:

I also am dealing with ca 2729 level anxiety! The first time they did the test was July2019. (Mx 8/2018 and Chemo 9/2018-2/2019). In July my number was 28.3. In October my number was 32. My onc told me not to worry that numbers fluctuate. Just had the test again Dec 30th and it went up onepoint to 33. Again, all in normal range, but still concerns me, why aren’t they down!? My onc assures me nothing to worry about, only moving up one point. I also had test done at a different lab in July....could this explain the move from 28.3 to 32? My last breast mri showed benign fibroglandular tissue, can that cause a fluctuation? I’m sorry for rambling, I know God has me in his hand, but man, cancer just changes everything, will I ever really relax!?

Dx 6/2018, IDC, Left, 3cm, Grade 2, 5/8 nodes, ER+/PR+, HER2-
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Jan 10, 2020 03:30PM trinigirl50 wrote:

mine jump around all the time. 20s, 30s, 40s then back down and then up again. And yes different labs can make a difference. I dont bother with mine anymore, too much stress. If they make big jumps over 3 months, then it may be worth panicking. But for now, 28 to 33 doesnt seem like a big deal.

trinigirl50 Dx 3/7/2015, ILC, Left, 6cm+, Stage IIIC, Grade 2, 20/24 nodes, ER+/PR-, HER2- Surgery 3/7/2015 Lymph node removal: Underarm/Axillary; Mastectomy: Left; Prophylactic mastectomy: Right Chemotherapy 4/14/2015 AC + T (Taxotere) Hormonal Therapy 9/14/2015 Arimidex (anastrozole), Femara (letrozole) Radiation Therapy 10/1/2015 Whole-breast: Breast, Lymph nodes
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Jan 10, 2020 03:31PM trinigirl50 wrote:

inflammation causes mine to fluctuate.

trinigirl50 Dx 3/7/2015, ILC, Left, 6cm+, Stage IIIC, Grade 2, 20/24 nodes, ER+/PR-, HER2- Surgery 3/7/2015 Lymph node removal: Underarm/Axillary; Mastectomy: Left; Prophylactic mastectomy: Right Chemotherapy 4/14/2015 AC + T (Taxotere) Hormonal Therapy 9/14/2015 Arimidex (anastrozole), Femara (letrozole) Radiation Therapy 10/1/2015 Whole-breast: Breast, Lymph nodes
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Jan 14, 2020 08:09AM pesky904 wrote:

Thanks, all. I'm not worried, and honestly don't see why my MO even orders them. My numbers were in the normal range even when I was first diagnosed with a 7+ cm tumor, so I don't think these tests would ever tell me anything useful.

I was just curious if they jump around similar to the way your glucose level can be a different number every single time it's tested - it seems these markers are similar to that.

​dx 6/17 stage III TNBC 6cm tumor Taxol 7-8/17 tumor grew to 10cm AC 9-10/17 tumor shrunk to 3cm DMX 11/17 expanders placed Rads 33 doses + cisplatin 1/18 Cisplatin discontinued due to SEs Xeloda 4-10/2018 Exch surgery 11/18

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