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May 9, 2010 12:08PM
May 9, 2010 12:12PM
Well...theoretically, I can't take Tamox either (poor metabolizer) but there is so..so much contoversy with this test. Especially with pre menopausal woman because Tamox is THE only thing we can take. My onc explained to me that a poor metabolizer does not mean NO metabolzer. It just means it takes longer for the Tamox to do it's thing and how much I'm actually metabolizing? We don't know.
So. What does that mean for me?
Well, I don't want to be my own trial and "see what happens". Forget it. So, since I'm only 32 and still highly premenopausal, I decided to get the ovaries out now, than later. I asked my onc what I was suppose to do. Take the Lupron untill I hit natural menopause? Pfffttt....ok. That could be another 15 yrs! Plus, my Lupron is only covered for the first 3 yrs since finishing treatment. Why? Because studies to date only have this info, overall survival with 3 yrs of Lupron vs nothing. The SOFT trial will answer all these questions for us pre meno woman.The SOFT trial will be answering for 5 yrs and if Lupron with Tamox is better than Lupron with an AI. Or Tamox is just fine.
I asked my onc straight out, "what do you think I should do?" My onc said very honestly, that with us pre meno woman they ,the reasearchers,just don't know enough right now. AND....any news regarding the SOFT trial will be years away.
mom.....I can't wait years and take a gamble. I have to do what I know now. Most of it, is my own research, other womans stories I've read on various B.C. boards and my own gut feeling.
So thats me.
As for testing estrogen levels...it's a blood test. I do not get my estrogen levels checked, but I don't need to because I'm on Tamox still. Even though I'm on the Lupron, if I did test and it said that I wasn't fully in menopause, thats ok......being on the Tamox. NOT, the AI.
Tamox and Ai's work differently. Tamox binds on to the estrogen in our bodies, where an AI....stops to help the production.
Edit: Our bodies also produce estrogen in our adrenal glands and excess fat. Thats why they say a reducing excess weight and exercising to keep off the pounds will help lower our chances of developing BC or getting a recurrence.
Dx:2007, 2B, Triple+, June 2008:Lupron,Zometa,Tamox.Jan 2010:Poor metabolizer of Tamox switch to Femara.Feb 2010: cyp2d6 test reliable? Back to Tamox. Ooph soon.