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Jan 13, 2017 10:36AM
hi Simplelife, sorry you have had to join us. Glad you found the thread.
You have asked some very searching questions! I will try my best to answer them.... here goes
1. Is an imbalance in hormones the cause of ER+ and PR+ BC?
The cause of ER+ PR+ BC like other forms of BC, is poorly understood. It is most likely multifactorial with contributions from genes and environment. There is no strong suggestion that hormone imbalance is the cause but high estrogen levels over many years from the birth control pill or hormone replacement therapy do increase risk. The hormone imbalance you describe about yourself seem to me, based on the info you have given, to be that you were perimenopausal which can cause estrogen levels to be very high as well as very low, and suffering from adrenal fatigue which is and adrenal imbalance caused by stress. Stress is bad for the immune system but many people suffer from chronic stress and don't get cancer! But of course it may be one ingredient in the complex cancer recipe!
2. Are there any studies indicating women's' hormone levels prior to a BC diagnoses?
I don't know the answer but I think no good evidence to show this, you will always find anecdotes from "Dr Google"
3. If we can simply balance our hormones, will this prevent a recurrence? Are there any studies related to this?
With ER+ breast cancer suppressing estrogen levels helps to reduce risk of recurrence. That is why Tamoxifen, aromatase inhibitors and ovarian suppression are often used. Some of the benefits of chemotherapy in younger women may also relate to the fact that it suppresses ovary function and sometimes triggers early menopause. There are no data looking at any sort of "rebalancing of hormones". However stress is bad for ALL chronic illnesses and cancer is no different and reducing stress is only going to be beneficial.
4. Or do we have to take some kind of HRT to get rid of our estrogen altogether (or remove our ovaries)?
I think I answered this above?
I wish you all the best with your treatment plan
Multifocal IDC, oncoDX 8 & 1. No chemo. Left Mx, exchange to implant April 25th 2012. Tamoxifen & zoladex
6/22/2011, IDC, 1cm, Stage I, Grade 1, 0/10 nodes, ER+/PR+, HER2-