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Topic: Stage 1, grade 1 and pre-menopausal

Forum: Stage I Breast Cancer — Meet other members with a Stage I breast cancer diagnosis to share information and support.

Posted on: Aug 23, 2011 03:25AM - edited Jun 12, 2012 03:18PM by Annicemd

Annicemd wrote:

hi sisters,
It has struck me that most grade 1, stage 1 sisters seem to be post-menopausal (aka low estrogen) and younger women seem to be more often stage 2/grade 2. I am 42, recently diagnosed ER positive, still full of estrogen and becoming a little paranoid that there is something different about me or my cancer! I am not having chemo as i dont qualify for it. Low oncoDX score etc. On tamoxifen but am a little worried that my long term outcome may be worse because am am in no-mans land!! Are there any sisters out there in similar situation??***************************************************************************************************

May 2012 Decided to update this post as your responses have shown me that there are many of us who started out premenopausal with stage 1 grade 1 disease! What has become evident is that the choices for treatment can be tricky for us. Dilemmas include whether or not to use ovarian suppression or ooph (the definitive study - the SOFT trial will start to publish results hopefully around winter 2013), whether to do chemox if oncotype is intermediate (there is a study looking at this -The TAILORx but results are years off, whether adding zometa to treatment helps reduce recurrence (data remain somewhat conflicting although there appears to be a benefit for women over 40 years provided they are also treated with ovarian suppression), whether ovarian suppression alone or in combination with AI is a good alternative to tamoxifen for those of us who can't take/tolerate tamoxifen (TEXT trial results anticipated with SOFT results) and does Cyp2d6 status matter? So if you are stage 1, grade 1 and diagnosed when you were pre-menopausal you are definitely not alone. There is not a "one size fits all" answer to how we should be treated but hearing the treatment routes others have chosen does help with decision making... and optimism, there are 20 year survivors posting here! >

Multifocal IDC, oncoDX 8 & 1. No chemo. Left Mx, exchange to implant April 25th 2012. Tamoxifen & zoladex Dx 6/22/2011, IDC, 1cm, Stage I, Grade 1, 0/10 nodes, ER+/PR+, HER2-
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Dec 11, 2019 07:57AM Annicemd wrote:

itā€™s all good šŸ˜Š NED so far! We must all enjoy the time we have šŸ‘ŒšŸ»

Multifocal IDC, oncoDX 8 & 1. No chemo. Left Mx, exchange to implant April 25th 2012. Tamoxifen & zoladex Dx 6/22/2011, IDC, 1cm, Stage I, Grade 1, 0/10 nodes, ER+/PR+, HER2-
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Dec 28, 2019 03:24AM Prahan wrote:

Hello all how many years it take for grade 1 cancer cells to become 1 cm lump?. Any idea?

Dx 3/18/2019, IDC, Left, 1cm, Stage IB, Grade 1, 1/1 nodes, ER+/PR+, HER2- (IHC) Surgery 3/28/2019 Lumpectomy: Left Hormonal Therapy 5/8/2019 Tamoxifen pills (Nolvadex, Apo-Tamox, Tamofen, Tamone), Zoladex (goserelin) Radiation Therapy 5/8/2019 Whole-breast: Breast, Lymph nodes
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Dec 28, 2019 04:10AM Annicemd wrote:

No one really knows but as they are very lazy, probably several years..

Multifocal IDC, oncoDX 8 & 1. No chemo. Left Mx, exchange to implant April 25th 2012. Tamoxifen & zoladex Dx 6/22/2011, IDC, 1cm, Stage I, Grade 1, 0/10 nodes, ER+/PR+, HER2-
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Dec 28, 2019 05:48AM Prahan wrote:

Thanks for replying. Yes ,no research based on this.

Dx 3/18/2019, IDC, Left, 1cm, Stage IB, Grade 1, 1/1 nodes, ER+/PR+, HER2- (IHC) Surgery 3/28/2019 Lumpectomy: Left Hormonal Therapy 5/8/2019 Tamoxifen pills (Nolvadex, Apo-Tamox, Tamofen, Tamone), Zoladex (goserelin) Radiation Therapy 5/8/2019 Whole-breast: Breast, Lymph nodes
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Dec 28, 2019 06:12PM voraciousreader wrote:

mine was sitting on my imaging for at least three years and was mistaken for a cyst...gyno finally felt it and said it was time for a biopsy...and as they say...the rest was history.... that was 10 years ago!



Doctor told me regarding my prognosis that I WASN'T on the Titanic! Hmmm...Really?....Okay! 02/2010 Pure Mucinous Breast Cancer, Oncotype DX 15, Stage 1, Grade 1, 1.8 cm, 0/2 nodes, ER+ 90% /PR+ 70% HER2- (+1)
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Dec 29, 2019 12:48AM Annicemd wrote:

Thanks for sharing VR. I actually had an ultrasound 7 years before my diagnosis after having bad mastitis during breast feeding my youngest. The ultrasanographer was looking at one area for ages before giving me the all clear! I was 34 at the time. Mammo was normal. 7 years later ID diagnosed in that exact area. I will never know what she saw in the first place and if it may have been DCIS at that time...

Multifocal IDC, oncoDX 8 & 1. No chemo. Left Mx, exchange to implant April 25th 2012. Tamoxifen & zoladex Dx 6/22/2011, IDC, 1cm, Stage I, Grade 1, 0/10 nodes, ER+/PR+, HER2-
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Dec 29, 2019 02:14PM voraciousreader wrote:

Annice....no sense in looking back....Carpe Diem!


happy New Year dear sisters! And may all the year be filled with only wonderful surprises

Doctor told me regarding my prognosis that I WASN'T on the Titanic! Hmmm...Really?....Okay! 02/2010 Pure Mucinous Breast Cancer, Oncotype DX 15, Stage 1, Grade 1, 1.8 cm, 0/2 nodes, ER+ 90% /PR+ 70% HER2- (+1)
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Dec 29, 2019 11:33PM Annicemd wrote:

indeed, hereā€™s to a Happy New Decade šŸŽ‰

Multifocal IDC, oncoDX 8 & 1. No chemo. Left Mx, exchange to implant April 25th 2012. Tamoxifen & zoladex Dx 6/22/2011, IDC, 1cm, Stage I, Grade 1, 0/10 nodes, ER+/PR+, HER2-
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Jan 1, 2020 06:29AM Prahan wrote:

My pathology report says predominantly arranged in tubules with nests and cords. Score was given 1 . This means my type may be Tubular Carcinoma. My ki67 value is 3to 4 % .

Dx 3/18/2019, IDC, Left, 1cm, Stage IB, Grade 1, 1/1 nodes, ER+/PR+, HER2- (IHC) Surgery 3/28/2019 Lumpectomy: Left Hormonal Therapy 5/8/2019 Tamoxifen pills (Nolvadex, Apo-Tamox, Tamofen, Tamone), Zoladex (goserelin) Radiation Therapy 5/8/2019 Whole-breast: Breast, Lymph nodes
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Jan 4, 2020 09:13AM - edited Jan 4, 2020 09:17AM by beach2beach

I was 51 and pre-meno when diagnosed. Now at 53 still have high levels of estrogen(recently checked in december) even though since being on tamoxifen I have not had a period in the last year. Not sure if I wasn't on Tamox if I'd still be getting periods, wonky probably, but still getting them.

Had an Oncodx score of 9, no chemo or rads. Go every 6mths to onco and once year to breast surgeon. Like everyone else, we hope we have done is enough. I'm guessing because I'd be considered going through menopuase that they would not do ovarian surpression..idk, I will ask this at next onco appt in June

Dx 7/28/2017, LCIS/DCIS/ILC, Right, <1cm, Stage IA, Grade 1, 0/2 nodes, ER+/PR+, HER2- Surgery 8/7/2017 Mastectomy: Left, Right; Reconstruction (left); Reconstruction (right) Hormonal Therapy 9/11/2017 Tamoxifen pills (Nolvadex, Apo-Tamox, Tamofen, Tamone)
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Jan 10, 2020 06:04PM Prahan wrote:

Any one experiencing dry throat on lupron and Tamoxifen

Dx 3/18/2019, IDC, Left, 1cm, Stage IB, Grade 1, 1/1 nodes, ER+/PR+, HER2- (IHC) Surgery 3/28/2019 Lumpectomy: Left Hormonal Therapy 5/8/2019 Tamoxifen pills (Nolvadex, Apo-Tamox, Tamofen, Tamone), Zoladex (goserelin) Radiation Therapy 5/8/2019 Whole-breast: Breast, Lymph nodes
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Jan 11, 2020 06:39AM Annicemd wrote:

Oh that is quite a non specific symptoms that could be caused by many things. Hopefully it will settle down. Canā€™t say I had it when I was on lupron, and I personally have not had it with tamoxifen either..

Multifocal IDC, oncoDX 8 & 1. No chemo. Left Mx, exchange to implant April 25th 2012. Tamoxifen & zoladex Dx 6/22/2011, IDC, 1cm, Stage I, Grade 1, 0/10 nodes, ER+/PR+, HER2-
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Jan 11, 2020 07:23PM Prahan wrote:

Thank you for your response Annicemd.

The updated SOFT trial recommends ovarian suppression for 18 or 24 months?.

Do we have any statistical data published recently, regarding our prognosis?


Dx 3/18/2019, IDC, Left, 1cm, Stage IB, Grade 1, 1/1 nodes, ER+/PR+, HER2- (IHC) Surgery 3/28/2019 Lumpectomy: Left Hormonal Therapy 5/8/2019 Tamoxifen pills (Nolvadex, Apo-Tamox, Tamofen, Tamone), Zoladex (goserelin) Radiation Therapy 5/8/2019 Whole-breast: Breast, Lymph nodes
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Jan 12, 2020 12:49AM Annicemd wrote:

I am not aware. Others may have more recent info. Many women use the on line tools at diagnosis such as life math or predict which I think take account or established outcome research. The ovarian suppression plus tamoxifen certain appears to improve outcomes in premenopausal women with early stage BC.. I certainly had a similar treatment to what you are being offered. I was not initially offered OS but I realised it was likely to be beneficial and now the data are clear so I am glad I pushed for it šŸ˜Š

Multifocal IDC, oncoDX 8 & 1. No chemo. Left Mx, exchange to implant April 25th 2012. Tamoxifen & zoladex Dx 6/22/2011, IDC, 1cm, Stage I, Grade 1, 0/10 nodes, ER+/PR+, HER2-
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Jan 12, 2020 06:07AM voraciousreader wrote:

https://www.nejm.org/doi/full/10.1056/NEJMoa1803164

Tailoring Adjuvant Endocrine Therapy for Premenopausal Breast Cancer....2018
most recent data...



Doctor told me regarding my prognosis that I WASN'T on the Titanic! Hmmm...Really?....Okay! 02/2010 Pure Mucinous Breast Cancer, Oncotype DX 15, Stage 1, Grade 1, 1.8 cm, 0/2 nodes, ER+ 90% /PR+ 70% HER2- (+1)
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Jan 14, 2020 01:18AM Prahan wrote:

Thank you voracious reader.

Dx 3/18/2019, IDC, Left, 1cm, Stage IB, Grade 1, 1/1 nodes, ER+/PR+, HER2- (IHC) Surgery 3/28/2019 Lumpectomy: Left Hormonal Therapy 5/8/2019 Tamoxifen pills (Nolvadex, Apo-Tamox, Tamofen, Tamone), Zoladex (goserelin) Radiation Therapy 5/8/2019 Whole-breast: Breast, Lymph nodes
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Jan 21, 2020 06:22AM Prahan wrote:

Any long term survivors say 10 years is still posting here? .

Dx 3/18/2019, IDC, Left, 1cm, Stage IB, Grade 1, 1/1 nodes, ER+/PR+, HER2- (IHC) Surgery 3/28/2019 Lumpectomy: Left Hormonal Therapy 5/8/2019 Tamoxifen pills (Nolvadex, Apo-Tamox, Tamofen, Tamone), Zoladex (goserelin) Radiation Therapy 5/8/2019 Whole-breast: Breast, Lymph nodes
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Jan 21, 2020 05:00PM voraciousreader wrote:

Yes. I am

Doctor told me regarding my prognosis that I WASN'T on the Titanic! Hmmm...Really?....Okay! 02/2010 Pure Mucinous Breast Cancer, Oncotype DX 15, Stage 1, Grade 1, 1.8 cm, 0/2 nodes, ER+ 90% /PR+ 70% HER2- (+1)
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Jan 21, 2020 09:00PM Prahan wrote:

Cheers voracious reader

Dx 3/18/2019, IDC, Left, 1cm, Stage IB, Grade 1, 1/1 nodes, ER+/PR+, HER2- (IHC) Surgery 3/28/2019 Lumpectomy: Left Hormonal Therapy 5/8/2019 Tamoxifen pills (Nolvadex, Apo-Tamox, Tamofen, Tamone), Zoladex (goserelin) Radiation Therapy 5/8/2019 Whole-breast: Breast, Lymph nodes
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Jan 22, 2020 05:15PM voraciousreader wrote:

prahan...Heart

Doctor told me regarding my prognosis that I WASN'T on the Titanic! Hmmm...Really?....Okay! 02/2010 Pure Mucinous Breast Cancer, Oncotype DX 15, Stage 1, Grade 1, 1.8 cm, 0/2 nodes, ER+ 90% /PR+ 70% HER2- (+1)
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Jan 23, 2020 08:29AM Prahan wrote:

Voracious reader , do you know your ki67 value?.

Dx 3/18/2019, IDC, Left, 1cm, Stage IB, Grade 1, 1/1 nodes, ER+/PR+, HER2- (IHC) Surgery 3/28/2019 Lumpectomy: Left Hormonal Therapy 5/8/2019 Tamoxifen pills (Nolvadex, Apo-Tamox, Tamofen, Tamone), Zoladex (goserelin) Radiation Therapy 5/8/2019 Whole-breast: Breast, Lymph nodes
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Jan 23, 2020 03:41PM voraciousreader wrote:

No. but I had the Breast Cancer Index (BCI) score after 7 years of Tamoxifen/Femara....and my score was extremely low...1.8...so, after my 8th year, with further studies indicating for patients of low risk of recurrence, no further benefit...I stopped therapy.....I am nowhappy and HEALTHY.

Doctor told me regarding my prognosis that I WASN'T on the Titanic! Hmmm...Really?....Okay! 02/2010 Pure Mucinous Breast Cancer, Oncotype DX 15, Stage 1, Grade 1, 1.8 cm, 0/2 nodes, ER+ 90% /PR+ 70% HER2- (+1)
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Jan 24, 2020 04:04AM Prahan wrote:

I am lay man. Please describe how this test is done. Blood work?. Is that available in India

Dx 3/18/2019, IDC, Left, 1cm, Stage IB, Grade 1, 1/1 nodes, ER+/PR+, HER2- (IHC) Surgery 3/28/2019 Lumpectomy: Left Hormonal Therapy 5/8/2019 Tamoxifen pills (Nolvadex, Apo-Tamox, Tamofen, Tamone), Zoladex (goserelin) Radiation Therapy 5/8/2019 Whole-breast: Breast, Lymph nodes
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Jan 24, 2020 06:59AM Badluckbdaygirl wrote:

Hi Stage 1 sisters.

I am glad I found this post. I had a BMX in December. I waited a few weeks to recover m, delayed meeting my mo, but and am finally meeting my MO next week to start Tamoxifen. My BS said they brought my case up and my future MO said she would not be ordering the Onco test. Should I demand one? I havenā€™t even met her yet, but she is the one Iā€™m most nervous aboutšŸ¤Ŗ She believed from what she saw Tamoxifen would give the greatest benefit.

I had to convince my BS to do a BMX, but after surgery he was glad because they found other (LCIS/DCIS) and I have extremely dense breasts with many call backs and a biopsy in the past. My biopsy that found my cancer was on my 46th bday.

Another question I have is that I am definitely pre-menopausal. Periods like clockwork with my IDC er+ 98%. Should I have my ovaries removed? What else can I do for lowering estrogen?

Thanks for listening. Itā€™s all so confusing

Dx 10/28/2019, IDC, Right, <1cm, Stage IA, Grade 1, 0/3 nodes, ER+/PR+, HER2- (FISH) Surgery 12/10/2019 Lymph node removal: Sentinel, Underarm/Axillary; Mastectomy: Left, Right; Prophylactic mastectomy: Left; Reconstruction (left): Tissue expander placement; Reconstruction (right): Tissue expander placement Dx 12/13/2019, LCIS/DCIS, Right, Grade 2, 0/3 nodes Dx 12/13/2019, IDC, Right, <1cm, Stage IA, Grade 1, 0/3 nodes, ER+/PR+, HER2- (FISH) Hormonal Therapy 2/27/2020 Tamoxifen pills (Nolvadex, Apo-Tamox, Tamofen, Tamone) Surgery 3/6/2020 Reconstruction (left): Nipple reconstruction, Silicone implant; Reconstruction (right): Nipple reconstruction, Silicone implant
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Jan 24, 2020 09:14AM - edited Jan 24, 2020 09:16AM by voraciousreader

http://www.biotheranostics.com/patient-breast-cancer


Prahan...check out the above link... not sure if it is offered in India.... keep us posted

Doctor told me regarding my prognosis that I WASN'T on the Titanic! Hmmm...Really?....Okay! 02/2010 Pure Mucinous Breast Cancer, Oncotype DX 15, Stage 1, Grade 1, 1.8 cm, 0/2 nodes, ER+ 90% /PR+ 70% HER2- (+1)
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Jan 24, 2020 09:21AM voraciousreader wrote:

birthday girl. Most definitely you want the OncotypeDx test done. Ask surgeon to do it so you might have results when you see oncologist. Ovarian suppression can also be obtained by using chemicals. For three years, I had monthly Lupron injections that suppressed my ovaries from releasing eggs. Some women do that and see how it goes. I never needed to remove my ovaries because after three years, I was finally, post menopausal....That is something to discuss with the oncologist. In the meantime, try contacting the surgeon and get the OncotypeDX test...


keep us posted. Good luck

Doctor told me regarding my prognosis that I WASN'T on the Titanic! Hmmm...Really?....Okay! 02/2010 Pure Mucinous Breast Cancer, Oncotype DX 15, Stage 1, Grade 1, 1.8 cm, 0/2 nodes, ER+ 90% /PR+ 70% HER2- (+1)
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Jan 24, 2020 09:48AM Prahan wrote:

Thank you voracious reader.

Dx 3/18/2019, IDC, Left, 1cm, Stage IB, Grade 1, 1/1 nodes, ER+/PR+, HER2- (IHC) Surgery 3/28/2019 Lumpectomy: Left Hormonal Therapy 5/8/2019 Tamoxifen pills (Nolvadex, Apo-Tamox, Tamofen, Tamone), Zoladex (goserelin) Radiation Therapy 5/8/2019 Whole-breast: Breast, Lymph nodes
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Jan 24, 2020 11:42AM SummerAngel wrote:

Badluckbdaygirl, if you can get an Oncotype done that could help you decide about ovarian suppression. (I'm not sure if Oncotype has a size limit on the tumor sample, your signature says yours is less than 1 cm.) I'm also still very premenopausal, nearly 5 years post-diagnosis, and ovarian suppression wasn't recommended for me because I had very low risk tumors. Grade 1 tumors are usually low risk.

Age at dx: 45. Oncotype, left-side tumor: 9. Right side had multifocal IDC and "extensive" LCIS. Isolated tumor cells in 1 right-side node. Dx 3/27/2015, IDC, Left, 2cm, Stage IIA, Grade 1, 0/3 nodes, ER+/PR+, HER2- (FISH) Dx 4/27/2015, IDC, Right, 1cm, Grade 1, 0/2 nodes, ER+/PR+, HER2- (FISH) Surgery 6/1/2015 Lymph node removal: Sentinel; Mastectomy: Left, Right Surgery 6/1/2015 Reconstruction (left): Tissue expander placement; Reconstruction (right): Tissue expander placement Surgery 8/27/2015 Reconstruction (left): Fat grafting, Silicone implant; Reconstruction (right): Fat grafting, Silicone implant Surgery 12/3/2015 Reconstruction (left): Fat grafting, Nipple reconstruction; Reconstruction (right): Fat grafting, Nipple reconstruction
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Jan 24, 2020 11:55AM Annicemd wrote:

Birthday girl I most certainly agree with voracious reader. Chemical menopause has good evidence for benefit with your stats. Ask your MO about pros and cons and the research evidence. By the way I am 8 and a half years out and it feels good šŸ˜‰

Multifocal IDC, oncoDX 8 & 1. No chemo. Left Mx, exchange to implant April 25th 2012. Tamoxifen & zoladex Dx 6/22/2011, IDC, 1cm, Stage I, Grade 1, 0/10 nodes, ER+/PR+, HER2-
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Jan 24, 2020 01:35PM SummerAngel wrote:

Be aware that ovarian suppression is not without side effects. Luckily I have a great MO who weighed the pros and cons with me and felt that with my low risk of recurrence the cons outweighed the pros. This was influenced by the fact that I had already experienced severe side effects from Tamoxifen. He felt that the side effects of ovarian suppression would most likely be as severe as, or more severe, than Tamoxifen. These are things you will want to discuss with your MO.

Age at dx: 45. Oncotype, left-side tumor: 9. Right side had multifocal IDC and "extensive" LCIS. Isolated tumor cells in 1 right-side node. Dx 3/27/2015, IDC, Left, 2cm, Stage IIA, Grade 1, 0/3 nodes, ER+/PR+, HER2- (FISH) Dx 4/27/2015, IDC, Right, 1cm, Grade 1, 0/2 nodes, ER+/PR+, HER2- (FISH) Surgery 6/1/2015 Lymph node removal: Sentinel; Mastectomy: Left, Right Surgery 6/1/2015 Reconstruction (left): Tissue expander placement; Reconstruction (right): Tissue expander placement Surgery 8/27/2015 Reconstruction (left): Fat grafting, Silicone implant; Reconstruction (right): Fat grafting, Silicone implant Surgery 12/3/2015 Reconstruction (left): Fat grafting, Nipple reconstruction; Reconstruction (right): Fat grafting, Nipple reconstruction

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