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Topic: oncotype scores..

Forum: Stage I Breast Cancer — Meet other members with a Stage I breast cancer diagnosis to share information and support.

Posted on: Feb 18, 2019 07:38PM

everetta wrote:

I am wondering the range of oncotype scores. They say the scores go up to 100 but most of the highs I have heard referenced are in the 30s..are there people who have scores in the 40 and up range?

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Posts 31 - 50 (50 total)

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Feb 20, 2020 04:00PM nonomimi5 wrote:

Sugar - Praying for you. I went through this almost 2 years ago. Luckily, I did radiation only and on Tam right now.

DX at 53. Surgery at 54. Oncotype 17 Dx 3/23/2018, DCIS/IDC/IDC: Tubular, Right, 2cm, Stage IIA, Grade 2, 0/3 nodes, ER+/PR+, HER2- (IHC) Surgery 4/30/2018 Lumpectomy; Lymph node removal Radiation Therapy 5/29/2018 Breast Hormonal Therapy 7/2/2018 Tamoxifen pills (Nolvadex, Apo-Tamox, Tamofen, Tamone)
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Feb 20, 2020 07:22PM Badluckbdaygirl wrote:

Mouse, I have no idea how to interpret. My score was 12, but 3% 9 years with Tamoxifen. Yours was 4 with a much higher score? Weird. I asked so many questions today, they said that were confident. Ugh

Dx 10/28/2019, IDC, Right, <1cm, Stage IA, Grade 1, 0/3 nodes, ER+/PR+, HER2- (FISH) Surgery 12/10/2019 Lymph node removal: Sentinel, Underarm/Axillary; Mastectomy: Left, Right; Prophylactic mastectomy: Left; Reconstruction (left): Tissue expander placement; Reconstruction (right): Tissue expander placement Dx 12/13/2019, IDC, Right, <1cm, Stage IA, Grade 1, 0/3 nodes, ER+/PR+, HER2- (FISH) Dx 12/13/2019, LCIS/DCIS, Right, Grade 2, 0/3 nodes Hormonal Therapy 2/27/2020 Tamoxifen pills (Nolvadex, Apo-Tamox, Tamofen, Tamone) Surgery 3/6/2020 Reconstruction (left): Nipple reconstruction, Silicone implant; Reconstruction (right): Nipple reconstruction, Silicone implant
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Feb 20, 2020 09:00PM - edited Feb 20, 2020 09:03PM by Mouse57

Hi Badluckbday

I had micromets in my lymph node - which put me on a different prediction table if you had nothing in your lymph nodes. Micromets mean its microscopic but still there. All the predictions are based on research and it keeps evolving - the micromets used to not even be detected.

DX age 61, invasive micropapillary, Nottingham 6/9 (3+2+1), ER+(90%), PR+(98%), HER2-(IHC 2.1, FISH 1.3), Oncotype Score 4/100 Dx 9/18/2019, DCIS/IDC, Right, 1cm, Stage IA, Grade 2, 1/1 nodes, ER+/PR+, HER2- (FISH) Surgery 10/24/2019 Lumpectomy: Right; Lymph node removal: Sentinel Radiation Therapy 1/5/2020 Whole-breast: Breast, Lymph nodes Hormonal Therapy 3/21/2020 Arimidex (anastrozole)
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Feb 20, 2020 09:36PM Peregrinelady wrote:

Interesting. My oncologist ordered the BCI for no nodes and my score was 12. ( 9% recurrence rate ). However, it was later discovered that my ITCs were actually micromets. Now, I am wondering what my recurrence % would have been with the other test. There seems to be a big discrepancy between the 2 tests, based on the scores reported here. Oh well, I am almost five years out and scored high on the BCI so I guess it is a moot point now. All of this information changes fairly rapidly with new tests coming out and new study results coming in.
Dx 4/24/2015, IDC, Left, 2cm, Stage IIB, Grade 2, 1/2 nodes, ER+/PR+, HER2- Hormonal Therapy 6/1/2015 Liquid tamoxifen (Soltamox) Surgery 4/17/2016 Mastectomy: Left, Right; Prophylactic ovary removal; Reconstruction (left): DIEP flap; Reconstruction (right): DIEP flap Hormonal Therapy 7/31/2016 Arimidex (anastrozole)
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Feb 20, 2020 09:39PM Peregrinelady wrote:

Mouse, is there any way you could share the graph you mentioned? Or see if it tells you the % for a score of 12? Just curious how it compares to what I thought was my % for the last almost 5 years. 😀
Dx 4/24/2015, IDC, Left, 2cm, Stage IIB, Grade 2, 1/2 nodes, ER+/PR+, HER2- Hormonal Therapy 6/1/2015 Liquid tamoxifen (Soltamox) Surgery 4/17/2016 Mastectomy: Left, Right; Prophylactic ovary removal; Reconstruction (left): DIEP flap; Reconstruction (right): DIEP flap Hormonal Therapy 7/31/2016 Arimidex (anastrozole)
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Feb 20, 2020 10:18PM - edited Feb 20, 2020 10:20PM by Mouse57

This is the graph = it is for micromets and 1-3 nodes positive - if I interpret it correctly, the lower scores do worse with CT - however, it is based on large database of (mostly) women and there may have been clinical reasons outside the oncotype score to recommend chemotherapy for some with low oncotype scores Also its tamoxfen results which don;t apply to me since I am post menopausal and will do AI

Also its

DX age 61, invasive micropapillary, Nottingham 6/9 (3+2+1), ER+(90%), PR+(98%), HER2-(IHC 2.1, FISH 1.3), Oncotype Score 4/100 Dx 9/18/2019, DCIS/IDC, Right, 1cm, Stage IA, Grade 2, 1/1 nodes, ER+/PR+, HER2- (FISH) Surgery 10/24/2019 Lumpectomy: Right; Lymph node removal: Sentinel Radiation Therapy 1/5/2020 Whole-breast: Breast, Lymph nodes Hormonal Therapy 3/21/2020 Arimidex (anastrozole)
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Feb 21, 2020 09:40PM Peregrinelady wrote:

Thanks, Mouse! It looks like it is only 2 or 3 % points between the tests.
Dx 4/24/2015, IDC, Left, 2cm, Stage IIB, Grade 2, 1/2 nodes, ER+/PR+, HER2- Hormonal Therapy 6/1/2015 Liquid tamoxifen (Soltamox) Surgery 4/17/2016 Mastectomy: Left, Right; Prophylactic ovary removal; Reconstruction (left): DIEP flap; Reconstruction (right): DIEP flap Hormonal Therapy 7/31/2016 Arimidex (anastrozole)
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Feb 27, 2020 11:30AM - edited Feb 27, 2020 11:31AM by Natural

Wow, you are knowledgeable. I wanted to pick your brain. My Mammaprint was ordered kind of as a side thought by my BS at 4 weeks postop. It was done on surgical bx. And results were high risk and luminal B. Shocked. Initial bx from core needle vacuum was grade 1 (tubule was 3 and others each 1), ki67 8%, idc with some dcis, 6mm, 99% estrogen and 80+%progesterone. Followup MRI was read by experienced radiologist and only knew where to look for tumor b/c of marker. USs x2 prior for wire placement and sentinel node did not show any growth. Bilateral reduction (large partial mastectomy with reduction on both sides) was negative for margins, tissue, and sentinel nodes. But path report said 9mm. I have upcoming appt with MO. I thought abt asking for new test. But what? And you are so right — the rep is who to talk to abt results. Very confusing since front page results are basically an aggregate for all high. I am discordant low clinical and high mammaprint with much better numbers. Thanks

Dx 9/2019, IDC, Right, <1cm, Stage IA, Grade 1, 0/2 nodes, ER+/PR+, HER2- (FISH) Surgery
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Feb 28, 2020 10:34AM Sugar77 wrote:

My Oncotype score is 30. The oncologist is recommending chemo - four rounds of TC. He said I'm on the cusp of high so chemo is my decision but I value his opinion and will very likely go ahead with it. Just wrapping my head around it. I did TC 10 years ago so I know what to expect. As I always say...it's no picnic but it's doable.


Surgery 9/25/2009 Lumpectomy: Right Dx 10/27/2009, IDC, Right, <1cm, Stage IA, Grade 3, 0/2 nodes, ER-/PR-, HER2- Chemotherapy 12/7/2009 Cytoxan (cyclophosphamide), Taxotere (docetaxel) Dx 12/5/2019, IDC, Right, 3cm, Stage IIA, Grade 2, 0/3 nodes, ER+/PR+, HER2- Surgery 1/27/2020 Mastectomy: Left, Right; Reconstruction (left): Tissue expander placement; Reconstruction (right): Tissue expander placement Chemotherapy 4/3/2020 Cytoxan (cyclophosphamide), Taxotere (docetaxel)
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Feb 28, 2020 01:03PM Sweettalker52 wrote:

Sugar, I'm now 2 infusions done out of 4 planned, dose-dense TC with Neulasta. Did you have Neulasta years ago when you had TC? My side effects from Round 2 so far aren't as bad as the first round. Some S.E. from the steroid. Best Wishes to you and to everyone here for a serene weekend. I had not been looking forward to my 68th birthday coming up in March, but now I am getting in the mood to celebrate. ThumbsUp


I am blessed. May you realize all of your blessings, too. After my lumpectomy, my Oncotype DX score came back 28, so I did chemo (dose-dense TC with Neulasta X 4), 21 day cycle. Then Radiation (25 + 5 boosters) and finally 5 years on an AI. Dx 12/5/2019, IDC, Left, 1cm, Stage IA, Grade 2, 1/6 nodes, ER+/PR+, HER2- (FISH) Surgery 12/17/2019 Lumpectomy: Left; Lymph node removal: Sentinel Chemotherapy 1/28/2020 Cytoxan (cyclophosphamide), Taxotere (docetaxel) Radiation Therapy 5/6/2020 3DCRT: Breast, Lymph nodes Hormonal Therapy Femara (letrozole)
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Feb 28, 2020 01:23PM Sugar77 wrote:

Hi Sweettalker - yes, I had Neulasta at each round of TC last night. Good luck with your last two treatments.

Surgery 9/25/2009 Lumpectomy: Right Dx 10/27/2009, IDC, Right, <1cm, Stage IA, Grade 3, 0/2 nodes, ER-/PR-, HER2- Chemotherapy 12/7/2009 Cytoxan (cyclophosphamide), Taxotere (docetaxel) Dx 12/5/2019, IDC, Right, 3cm, Stage IIA, Grade 2, 0/3 nodes, ER+/PR+, HER2- Surgery 1/27/2020 Mastectomy: Left, Right; Reconstruction (left): Tissue expander placement; Reconstruction (right): Tissue expander placement Chemotherapy 4/3/2020 Cytoxan (cyclophosphamide), Taxotere (docetaxel)
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Mar 5, 2020 08:37AM Sweettalker52 wrote:

Thanks, Sugar77. How did you do with Neulasta side effects this time? Wishing you the best...

I am blessed. May you realize all of your blessings, too. After my lumpectomy, my Oncotype DX score came back 28, so I did chemo (dose-dense TC with Neulasta X 4), 21 day cycle. Then Radiation (25 + 5 boosters) and finally 5 years on an AI. Dx 12/5/2019, IDC, Left, 1cm, Stage IA, Grade 2, 1/6 nodes, ER+/PR+, HER2- (FISH) Surgery 12/17/2019 Lumpectomy: Left; Lymph node removal: Sentinel Chemotherapy 1/28/2020 Cytoxan (cyclophosphamide), Taxotere (docetaxel) Radiation Therapy 5/6/2020 3DCRT: Breast, Lymph nodes Hormonal Therapy Femara (letrozole)
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Mar 5, 2020 11:11AM Sugar77 wrote:

Sweettalker - I did fine with the Neulasta. I remember taking part in a bone pain study and had next to no issues. I took Claritin for five days with each shot and I think it helped.

Surgery 9/25/2009 Lumpectomy: Right Dx 10/27/2009, IDC, Right, <1cm, Stage IA, Grade 3, 0/2 nodes, ER-/PR-, HER2- Chemotherapy 12/7/2009 Cytoxan (cyclophosphamide), Taxotere (docetaxel) Dx 12/5/2019, IDC, Right, 3cm, Stage IIA, Grade 2, 0/3 nodes, ER+/PR+, HER2- Surgery 1/27/2020 Mastectomy: Left, Right; Reconstruction (left): Tissue expander placement; Reconstruction (right): Tissue expander placement Chemotherapy 4/3/2020 Cytoxan (cyclophosphamide), Taxotere (docetaxel)
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Jun 21, 2020 06:13PM Noone10 wrote:

Hello All,

Does anyone know if you have to get the Oncotype test done before you start your hormone therapy? I have read that a couple of places but I don't see it on the Oncotype website. Do you know if you have the Oncotype done after your start your hormone therapy, does it impact the results? If so, what are the impacts?

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Jun 25, 2020 06:49PM Rebalilly wrote:

Thought I would share...

Waiting for my Oncotype score was stressful. I found Magee Equation. I am unable to post a link at this time but if you search for it and add Oncotype score, it will pop up

By putting in my specific information, the Magee Equation results stated my Oncotype score would be 17.89.

When my Oncotype score came in, it was 18. The Magee Equation was spot on. Thought someone might find a bit of peace using it, as I did.

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Jun 25, 2020 07:33PM Beesie wrote:

Here's the link to the Magee Equation: https://path.upmc.edu/onlineTools/MageeEquations.html

It would be interesting to hear if other people find it to be accurate as well.

“No power so effectually robs the mind of all its powers of acting and reasoning as fear.” Edmund Burke
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Jun 25, 2020 09:40PM Murfy wrote:

My equation score was 26, translating to an intermediate Oncotype score which was not my case. I think there may be exceptions due to type of mutation predisposing one to their BC.


Dx at 62: Oncotype=52; Path (ER=99%, PR=0%, Ki67=55%) Dx 10/2017, DCIS/IDC, Left, 1cm, Stage IA, Grade 3, 0/5 nodes, ER+/PR-, HER2- Surgery 11/14/2017 Mastectomy: Left Chemotherapy 1/13/2018 Cytoxan (cyclophosphamide), Taxotere (docetaxel) Hormonal Therapy 3/31/2018 Aromasin (exemestane)
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Jun 26, 2020 04:47AM Whatjusthappened wrote:

I put in my information in the Magee Equation and got a 12.8. My oncotype was a 13, so pretty accurate in my case. My original pathology showed the Her2 to be equivocal, and if I used Her2 equivocal instead of negative, it gave me a score of 14.2.

BRCA2 positive; multifocal LCIS/ILC found after sugery Dx 2/1/2019, LCIS/ILC, Right, 4cm, Stage IB, Grade 2, 1/3 nodes, ER+/PR+, HER2- (FISH) Surgery 2/22/2019 Mastectomy: Right; Prophylactic mastectomy: Left Radiation Therapy 4/23/2019 External: Lymph nodes, Chest wall Surgery 6/17/2019 Prophylactic ovary removal Hormonal Therapy Arimidex (anastrozole)
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Jun 26, 2020 05:08AM DebAL wrote:

Morning all, magee 25.5, oncotype 27 so pretty close . It also seems , in general, that ki67 and oncotype scores tend to be in really close proximity. There was a thread on that not too long ago and I found that interesting. Always exceptions of course

Dx 1/22/2018, IDC, Left, <1cm, Stage IA, Grade 1, 0/3 nodes, ER+/PR-, HER2- (IHC) Surgery 2/11/2018 Reconstruction (left): Tissue expander placement; Reconstruction (right): Tissue expander placement Surgery 2/12/2018 Mastectomy: Left, Right Chemotherapy 4/2/2018 Cytoxan (cyclophosphamide), Taxotere (docetaxel) Hormonal Therapy 6/13/2018 Arimidex (anastrozole) Surgery 8/8/2018 Reconstruction (left): Fat grafting, Silicone implant; Reconstruction (right): Fat grafting, Silicone implant Surgery 12/19/2018 Reconstruction (left): Fat grafting; Reconstruction (right): Fat grafting Surgery
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Jun 27, 2020 09:31PM thecargirl wrote:

My Oncotype RS was 32% with 22% 10 year risk, the RSCP had a 6% 10year risk!! The Magee average score was 13.21748!

LT Lumpectory 9/16 7mm pure mucinous, 95% strong ER, 95% strong PR. Hr2- neg lymph

Radiation

Arimidex 2 years

Susan




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