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Topic: oncotype scores..

Forum: Stage I Breast Cancer — Meet other members with a Stage I breast cancer diagnosis to share information and support.

Posted on: Feb 19, 2019 02:38PM

everetta wrote:

I am wondering the range of oncotype scores. They say the scores go up to 100 but most of the highs I have heard referenced are in the 30s..are there people who have scores in the 40 and up range?

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Jul 30, 2020 11:48AM farmerlucy wrote:

my Magee caculates to around 17.

Even if I put in the lowest possible grade 3/9, 300 each for Er/Pr, and 1 ki67, it only gets down to around a 7 for my 1.1 cm tumor. There must be something else that comes up with the ultra low oncotype score.

Dx at 51 after a preventive mx that wasn't. Oncotype dx 3. 3D tattoos from Vinnie! PTSD?? You are not alone! Surgery 2/21/2012 Prophylactic mastectomy; Reconstruction (left): Tissue expander placement; Reconstruction (right): Tissue expander placement Dx 2/24/2012, IDC, Right, 1cm, Stage IA, Grade 2, 0/1 nodes, ER+/PR+, HER2- (FISH) Surgery 3/11/2012 Lymph node removal: Sentinel Surgery 7/22/2012 Reconstruction (left): Silicone implant; Reconstruction (right): Silicone implant Hormonal Therapy 4/10/2013 Tamoxifen pills (Nolvadex, Apo-Tamox, Tamofen, Tamone) Surgery 4/14/2015 Prophylactic ovary removal
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Jul 30, 2020 12:32PM Beesie wrote:

The Magee formula is a very simplified version of the Oncotype score. The Oncotype score has 16 inputs and 5 reference genes. Some are unfavorable factors that serve to increase the score, while others are favorable and decrease the score.

I posted this earlier in this thread:

farmerlucy, your cancer cells may have had a really strong presence of GDTM1 and BAG1, whatever they are. Or maybe a high Bcl2 or SCUBE2. Those are the genes that lower the score, in addition to having high ER and high PR.

Yeah, I'm thinking it was the SCUBE2. Happy

“No power so effectually robs the mind of all its powers of acting and reasoning as fear.” Edmund Burke
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Aug 13, 2020 12:58AM 2019whatayear wrote:

When I do the equation the average is 20 . My Onco score was 31. Go figure I guess. Even before the Oncotype test results came back - when my MO saw I had the BRCA2 mutation (tested before surgery to determine treatment plan) and a Ki-67 of 60 (biopsy) she considered me to be at a high risk of recurrence. I did read that if you have a high Ki-67 but also have a high ER AND PR it's not very determinant. I had like 100% ER and 95% PR, so there is that. Thanks for posting the equation. Since it gave me a significantly lower score than the Oncotype, I like that test LOL

IDC 2 cm micromets 1 node 8 more removed. BMX 6/24, A/C then Taxol 7/25, 25 rads 1/6/2020 No reconstruction BRCA2 - BSO 2/19 all clear/ starting AI on 3/1/2020

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