May 29, 2020 04:40AM - edited May 29, 2020 04:58AM by KeepingCalm
Yes, that happened to me although under slightly different circumstances and kicked me into doing chemo of which I'm now through 2 of 4 rounds so even though was initially very disappointed about that am now feeling like I'm making progress and so far hasn't been nearly as bad as one might think.
In my case I was on a 2 week clinical trial prior to surgery of a drug that MO feels could definitely have influenced the tumor proliferation factors that factor into the Oncotype. That said, a 2nd opinion felt that was just speculation and suggested a middle step could be to get the Mammaprint which would place me at either low or high risk instead of just over the line into intermediate as my Oncotype came back. The 2nd opinion also felt that even without Mammaprint I could reasonably make the decision to forgo chemo. However, insurance might not have covered the second test and more importantly for me one could speculate that there could have been the same underestimate issue.
In the end, while I am strongly Er+, my PR was + but low, but HER2- and all of that combined with my relatively young age (39) had my MO say that her projection for me was more like like 13% or so recurrence risk with just surgery and endocrine therapy and she said her perspective was that this was not a “good enough" outcome if the option of chemo + endocrine therapy could theoretically bump me well into less risk - in my case she suggested 5-7%. She felt this was more important given the number of decades ahead of me. That said it is of course a very personal decision and I don't know yet what being on long term endocrine therapy will be like. Stats have benefits but also don't account for everything. After all I fell into the much less likely I'm getting breast cancer at all in the first place at my age and am trying to do everything in my power to put me on the other side of those odds going forward.
Have you input your stats? In my case these were helpful to me in that the were very much in line with what my MO felt my recurrence risks are.http://www.lifemath.net/cancer/