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Topic: RSClin oncotype scores

Forum: Stage I Breast Cancer — Meet other members with a Stage I breast cancer diagnosis to share information and support.

Posted on: Jan 23, 2021 01:20AM

everetta wrote:

I have heard there is a new way of looking at the oncotype score that is a tool that takes into account your clinical features and gives an even more accurate predictive and diagnostic score. Does anyone know how you can find your RCSlin? I have a one centimeter ILC, node negative, grade 2 tumor and was 68 at diagnosis. I had a 31 oncotype but wonder what my RCSlin be?

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    Mar 12, 2021 04:49PM speedlady wrote:

    We are in a similar situation. I am 73, 1.1 cm, node negative, grade 1, oncotype 27. My oncologist said she couldn't recommend chemo either yes or no, it is up to me. I am saying no. I don't have that much life left and an additional 3% is not significant enough to ruin 2 years of my life.

    My oncologist showed me the RCSlin program during our consult. I didn't find it to be very useful.

    Dx 1/25/2021, ILC, Left, 1cm, Stage IA, Grade 1, 0/1 nodes, ER+/PR-, HER2- (IHC) Surgery 2/16/2021 Hormonal Therapy 3/18/2021 Radiation Therapy
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    Mar 12, 2021 05:16PM moth wrote:

    OP, your oncologist should how you the calculation. It's a calculator on a site that requires instititutional access.

    I take weekends off

    Initial dx at 50. Seriously?? “Sometimes the future changes quickly and completely and we’re left with only the choice of what to do next." blog: Never Tell Me the Odds

    Dx 12/2017, IDC, Left, 1cm, Stage IA, Grade 3, 0/5 nodes, ER-/PR-, HER2- (IHC) Surgery 12/12/2017 Lumpectomy: Left; Lymph node removal: Sentinel Chemotherapy 2/13/2018 AC + T (Taxol) Radiation Therapy 8/13/2018 Whole-breast: Breast Dx 2/2020, IDC, Stage IV, metastasized to liver/lungs, Grade 3, ER-/PR-, HER2- Chemotherapy 3/18/2020 Taxol (paclitaxel) Immunotherapy 3/18/2020 Tecentriq (atezolizumab) Chemotherapy 11/25/2020 Abraxane (albumin-bound or nab-paclitaxel) Radiation Therapy 12/8/2020 External Dx 12/9/2020, IDC, Right, Stage IV, metastasized to lungs, Grade 3, ER+/PR-, HER2- (IHC) Hormonal Therapy 12/15/2020 Femara (letrozole) Dx 1/28/2021, IDC, Left, Stage IV, metastasized to bone Radiation Therapy 3/2/2021 External: Bone
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    Mar 12, 2021 05:24PM Beesie wrote:

    speedlady, with the Oncotype 27, what did the report say your recurrence risk would be if you did endocrine therapy alone (i.e. no chemo). And after running the RSClin model, did this recurrence risk figure come down? I would think it would, given your age, your relatively small tumor and with the cancer being grade 1. All 3 factors are more favorable than the averages used to determine the Oncotype recurrence risk estimates.


    Dx 9/15/2005 Right, 7cm+, DCIS-Mi, Stage IA, Gr 3, 0/3 nodes, ER+/PR- ** Dx 01/16/2019 Left, 8mm, IDC, Stage IA, Gr 2, 0/3 nodes, ER+/PR-, HER2- (FISH) ** Surgery 11/30/2005 MX Right, 03/06/2019 MX Left ** Hormonal Therapy 05/2019 Letrozole
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    Apr 3, 2021 05:05PM speedlady wrote:

    Beesie, my recurrence risk with AI and radiation is 6%. Add chemo and it drops to 3%. To me it wasn't worth the extra 3% to go through chemo, especially at my age. If I were 20 years younger I'd do it. I can live with 94% chance of no recurrence. Thanks!

    Dx 1/25/2021, ILC, Left, 1cm, Stage IA, Grade 1, 0/1 nodes, ER+/PR-, HER2- (IHC) Surgery 2/16/2021 Hormonal Therapy 3/18/2021 Radiation Therapy
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    Apr 3, 2021 09:59PM thecargirl wrote:

    Bessie, do you think there is a big difference between RSCP and the RSClin model results . You enter the same information, it would be interesting to see the comparison. The RSCP really dropped my recurrence risk.

    Thanks,

    Susan

    Lt Lumpectomy 9/16,

    7mm pure mucinous, Stage 1, Grade 1, ER 95% PR 95%, HER-

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    Apr 3, 2021 10:40PM Beesie wrote:

    Susan, to my understanding RSClin would be considered an updated and refined version of the RSPC model. I don't know for sure but I suspect the results would be pretty similar.

    RSClin was "derived from a larger and more contemporaneously treated cohort than that used for the development of RSPC" and adds an "estimation of incremental absolute chemotherapy benefit not previously provided by RSPC".

    Development and Validation of a Tool Integratingthe 21-Gene Recurrence Score andClinical-Pathological Features to Individualize Prognosis and Prediction of Chemotherapy Benefit in Early Breast Cancer



    Dx 9/15/2005 Right, 7cm+, DCIS-Mi, Stage IA, Gr 3, 0/3 nodes, ER+/PR- ** Dx 01/16/2019 Left, 8mm, IDC, Stage IA, Gr 2, 0/3 nodes, ER+/PR-, HER2- (FISH) ** Surgery 11/30/2005 MX Right, 03/06/2019 MX Left ** Hormonal Therapy 05/2019 Letrozole
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    Apr 3, 2021 11:59PM thecargirl wrote:

    Thank-you Bessie!

    Susan

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    Apr 19, 2021 05:30PM - edited Apr 19, 2021 07:57PM by thecargirl

    Just a little update on my scores, my initial RS was 32 with a 10 year risk of DR of 22%. The Magee Equations recurrence score results were from 11.12 to 15.85 based solely on my pathology report, not the Oncotype RS. The RSCP resulted in a 10 year DR of 6%: the RSClin resulted in a 10 year DR of 7% , with a 4% absolute chemotherapy benefit. My MO feels there is little difference between the RSCP and the RSClin. Mucinous is a rare breast cancer, due to the small numbers in most of the studies, mucinous does not have a great representation in the conclusions.

    Lt Lumpectomy 9/16, 7mm pure mucinous, Grade 1, Stage 1, HER-2 neg, ER-95% strong, PR-95% strong

    Radiation, 2 years Arimidex

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    Apr 19, 2021 06:04PM Beesie wrote:

    thecargirl, that's great info!

    I'm glad to see that the RSPC and RSClin models came out with similar results. Not many MOs even knew about the RSPC model but RSClin has more research behind it and I think will end up being used more. That would be good. The reliance on Oncotype scores alone, without consideration to the pathology of the cancer, never made sense to me. Your 32 score, with a 7mm grade 1 tumor, logically would not present the same recurrence risk as a 32 score with a 3cm grade 3 tumor. The RSClin model doesn't ignore the Oncotype score - your risk, with a 32 score, will be higher than the risk of someone with an identical cancer who has a 10 score - but it builds in differences for tumor size, grade, and patient age. Yay! to progress!


    Dx 9/15/2005 Right, 7cm+, DCIS-Mi, Stage IA, Gr 3, 0/3 nodes, ER+/PR- ** Dx 01/16/2019 Left, 8mm, IDC, Stage IA, Gr 2, 0/3 nodes, ER+/PR-, HER2- (FISH) ** Surgery 11/30/2005 MX Right, 03/06/2019 MX Left ** Hormonal Therapy 05/2019 Letrozole
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    May 13, 2021 07:46PM - edited May 13, 2021 09:03PM by Pokemom1959

    Beesie - Do you know if there is anywhere online that we as laypeople have access to a RSClin calculator?

    Dx 11/7/2013, DCIS, <1cm, Stage 0, Grade 3, ER+/PR+ Surgery 1/22/2014 Lumpectomy: Left Radiation Therapy 1/22/2014 Breast Dx 1/23/2014, IDC, <1cm, Stage I, Grade 2, 0/2 nodes, ER+/PR+, HER2- Surgery 2/19/2014 Lymph node removal: Left, Sentinel Hormonal Therapy 4/7/2014 Dx 2/2021, IDC, Left, <1cm, Stage IA, Grade 3, ER+/PR+, HER2- Dx 4/16/2021, IDC, Left, 1cm, Stage IA, Grade 3, 0/1 nodes, ER+/PR+, HER2- Surgery 4/16/2021 Lumpectomy Hormonal Therapy Radiation Therapy
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    May 13, 2021 09:15PM Beesie wrote:

    Pokemom, it is made available by Genomic Health only to MOs.

    From your other post, it sounds as though your MO ran the RSClin model on your Oncotype score.



    Dx 9/15/2005 Right, 7cm+, DCIS-Mi, Stage IA, Gr 3, 0/3 nodes, ER+/PR- ** Dx 01/16/2019 Left, 8mm, IDC, Stage IA, Gr 2, 0/3 nodes, ER+/PR-, HER2- (FISH) ** Surgery 11/30/2005 MX Right, 03/06/2019 MX Left ** Hormonal Therapy 05/2019 Letrozole

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