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Topic: Announcing the Global Challenge to Prevent Breast Cancer

Forum: Advocacy — Join here to discuss issues where we can have a voice!

Posted on: Sep 28, 2018 12:27PM

CBCRP-Nick wrote:

Dear Forum Members,

I work for the California Breast Cancer Research Program (CBCRP), and I'm excited to announce that last week we launched the Global Challenge to Prevent Breast Cancer to encourage researchers and advocates to share transformative primary prevention ideas.

You can view the challenge at ToPreventBreastCancer.org.

This is a tremendous opportunity to change the trajectory of breast cancer research. Winners will influence $15 million in grant funding to be disseminated by CBCRP over the next five years, get a cash prize, receive feedback on their idea, and have the opportunity to present it to prominent leaders in the field.

As members of this forum, I thought you might be interested in applying. We're looking for both researchers and non-researchers alike to share breakthrough ideas.

Applications are due January 7, 2019. Two grand prize winners will receive $5,000 cash prizes.

Please consider applying and help me spread the word. Thank you. I'm happy to answer any questions you may have as well.

Sincerely,

Nick Anthis
Global Challenge to Prevent Breast Cancer
ToPreventBreastCancer.org
Challenge@CABreastCancer.org

--
Nicholas J. Anthis, DPhil
Program Officer, California Breast Cancer Research Program
University of California Office of the President
CABreastCancer.org

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Sep 28, 2018 05:35PM fredntan wrote:

This sounds interesting. I am stage 4 as you can see.

What if I did study to see if baby aspirin prevented BC? or something like that. I used to be a nurse. I have been in a clinical trial. I do have a lot of free time on my hands. Is there any guidance for non researchers? There are a lot of supplements people like me take to keep BC away. Like Turmeric, Frankinsence etc. Does the grant money have to go towards prevention?

MBC bone mets since 2013 Dx 8/3/2011, IDC, 2cm, Stage IIIA, Grade 2, 13/17 nodes, ER+/PR+, HER2- Surgery 9/8/2011 Lymph node removal: Right, Underarm/Axillary; Mastectomy: Right Radiation Therapy 3/28/2012 Breast, Lymph nodes Surgery 10/7/2012 Reconstruction (left): DIEP flap; Reconstruction (right): DIEP flap Surgery 4/2/2013 Reconstruction (left): Nipple reconstruction; Reconstruction (right): Nipple reconstruction Dx 10/2013, Stage IV, mets Chemotherapy 11/19/2013 Abraxane (albumin-bound or nab-paclitaxel), Fluorouracil (5-fluorouracil, 5-FU, Adrucil) Hormonal Therapy
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Sep 29, 2018 06:07AM Meow13 wrote:

I am not sure if we can do things to prevent BC when we don't know what caused it in the first place. The only thing you can do is take care of yourself to be as healthy as possible.

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Sep 29, 2018 10:45PM WC3 wrote:

Some questions:

Do traditional Japanese and Korean diets result in lower breast cancer rates?

Why does Mongolia have low rates of breast cancer despite a diet that consists almost exclusively of meat and dairy? Is it really lower or is it under reported?

How much estrogen is in American dairy products compared to Mongolian dairy products, and is there a relationship between estrogen content and breast cancer?

Same question as above for epidermal growth factor and IGF-1.

Is there a way to lower breast density other than taking tamoxifen?

Why does Belgium have such high breast cancer rates?


Pathologic complete response (pCR) to chemotherapy. Dx 2018, IDC, Left, 3cm, Grade 3, ER+/PR+, HER2+ (FISH) Chemotherapy 5/31/2018 Carboplatin (Paraplatin), Taxotere (docetaxel) Surgery 11/14/2018 Lymph node removal: Left, Sentinel; Mastectomy: Left, Right; Reconstruction (left): Tissue expander placement; Reconstruction (right): Tissue expander placement Hormonal Therapy Arimidex (anastrozole), Zoladex (goserelin) Targeted Therapy Perjeta (pertuzumab) Targeted Therapy Herceptin (trastuzumab) Hormonal Therapy Tamoxifen pills (Nolvadex, Apo-Tamox, Tamofen, Tamone) Surgery Reconstruction (left): Silicone implant; Reconstruction (right): Silicone implant
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Sep 30, 2018 02:10AM AliceBastable wrote:

Just from reading different boards here, it seems there are so many different kinds of breast cancer - hormone positive, hormone negative, triple negative, in situ, invasive, ductal, lobular, and many variations of each of those, not to mention the rarer types. So it seems unlikely that a prevention that's one-size-fits-all will be found, when the types of cancer and treatments vary so widely.

Endometrial cancer 2010, basal cell multiples, breast cancer 2018, kidney cancer 2018. Boring. Hope it stays that way. Dx 5/2018, ILC, Left, 2cm, Stage IA, Grade 1, 1/1 nodes, ER+/PR+, HER2- Surgery 7/11/2018 Lumpectomy: Left; Lymph node removal: Sentinel Surgery 8/8/2018 Radiation Therapy 10/29/2018 Whole-breast: Breast, Lymph nodes
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Sep 30, 2018 09:25AM WC3 wrote:

Another question:

Egg consumption is associated with increased mortality via an increase in rates of metastasis in prostate cancer. High levels of choline and the fact that prostate cancer cells have an abnormal choline metabolism are implicated in this. Breast cancer cells also have an abnormal choline metabolism so does the same hold true for breast cancer?


Pathologic complete response (pCR) to chemotherapy. Dx 2018, IDC, Left, 3cm, Grade 3, ER+/PR+, HER2+ (FISH) Chemotherapy 5/31/2018 Carboplatin (Paraplatin), Taxotere (docetaxel) Surgery 11/14/2018 Lymph node removal: Left, Sentinel; Mastectomy: Left, Right; Reconstruction (left): Tissue expander placement; Reconstruction (right): Tissue expander placement Hormonal Therapy Arimidex (anastrozole), Zoladex (goserelin) Targeted Therapy Perjeta (pertuzumab) Targeted Therapy Herceptin (trastuzumab) Hormonal Therapy Tamoxifen pills (Nolvadex, Apo-Tamox, Tamofen, Tamone) Surgery Reconstruction (left): Silicone implant; Reconstruction (right): Silicone implant
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Sep 30, 2018 09:48AM - edited Sep 30, 2018 09:48AM by ksusan

...or are there genetic differences between groups of people that affect BC rates? We know that CYP450 metabolism differs between Euro and Asian people.

Mutant uprising quashed. Dx 1/2015, IDC, Right, Stage IIA, 1/1 nodes, ER+/PR+, HER2- Dx 1/2015, DCIS, Left, Stage 0, Grade 3, 0/2 nodes Hormonal Therapy Tamoxifen pills (Nolvadex, Apo-Tamox, Tamofen, Tamone) Surgery Lymph node removal: Sentinel; Mastectomy: Left, Right Radiation Therapy Whole-breast Chemotherapy Cytoxan (cyclophosphamide), Taxotere (docetaxel)
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Sep 30, 2018 10:17AM Meow13 wrote:

I was told by multiple physicians my radiologist, my breast cancer surgeon and my top BC oncologist that why I got BC is unknown and nothing in my genetic makeup or lifestyle points to anything. Plain and simple totally unknown for my case. So there must be other absolute knowns out there for other cases. I applaud them if they can prevent this disease in anyone I just don't see it. Preventing BC doubt it reducing risks maybe.

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Oct 1, 2018 03:45AM DATNY wrote:

Wc3 regarding Mongolian....or Inuit....or similar. These populations escape immunomodulation by heavily "treating" with anti-inflammators and antibiotics every little cold and flu they get; perhaps they get less vaccines too. I think they fight infections mostly by waiting to pass, at most using some supplements but not western medicine which strongly interfere with immune system function.




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Oct 1, 2018 09:29AM CBCRP-Nick wrote:

> Sep 28, 2018 05:35PM fredntan wrote:

>> This sounds interesting. I am stage 4 as you can see.

>> What if I did study to see if baby aspirin prevented BC? or something like that. I used to be a nurse. I have been in a clinical trial. I do have a lot of free time on my hands. Is there any guidance for non researchers? There are a lot of supplements people like me take to keep BC away. Like Turmeric, Frankinsence etc. Does the grant money have to go towards prevention

fredntan - The Global Challenge is unique because applicants are just being asked to propose ideas for research, but not conduct the research themselves. You could propose an idea that could be carried out by anyone. We are very interested in ideas from both researchers and non-researchers, and we will have separate prizes for each category.

I appreciate all of the ideas, and I encourage folks to check out the website for the Global Challenge (ToPreventBreastCancer.org) and consider submitting some of your ideas to the Challenge!

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Oct 2, 2018 04:26PM WC3 wrote:

I think a lot of people here would like some more definitive dietary studies because diet is an easy to control for variable.

Also, it would be nice if there were studies better defining the role of progesterone and progestins in cancer development and inhibition. There were some planned clinical trials but I don't know if they ever got off the ground.


Pathologic complete response (pCR) to chemotherapy. Dx 2018, IDC, Left, 3cm, Grade 3, ER+/PR+, HER2+ (FISH) Chemotherapy 5/31/2018 Carboplatin (Paraplatin), Taxotere (docetaxel) Surgery 11/14/2018 Lymph node removal: Left, Sentinel; Mastectomy: Left, Right; Reconstruction (left): Tissue expander placement; Reconstruction (right): Tissue expander placement Hormonal Therapy Arimidex (anastrozole), Zoladex (goserelin) Targeted Therapy Perjeta (pertuzumab) Targeted Therapy Herceptin (trastuzumab) Hormonal Therapy Tamoxifen pills (Nolvadex, Apo-Tamox, Tamofen, Tamone) Surgery Reconstruction (left): Silicone implant; Reconstruction (right): Silicone implant
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Jun 30, 2019 04:41PM topdubu wrote:

Just returned from my second Mongolia trip. The meat thing is largely a myth these days. I eat significantly more meat here in the US. True, they have meat with most meals but it is like using hamburger helper in that they use lots of rice, pasta and bread to stretch the meat. In the far west, cheese and yogurt from goats, sheep and yak is abundant. In the cities, meat is becoming expensive as prices are being bid up principally due to surging Chinese consumption.

Dx 9/2003, DCIS, Right, 1cm, Stage 0, 0/1 nodes, ER+/PR+, HER2- Dx 9/2006, DCIS, Right, Stage 0, Grade 1, ER+/PR+, HER2- Dx 11/2016, Right, Stage IV, metastasized to bone/lungs, ER+/PR+, HER2- Hormonal Therapy 3/18/2020 Faslodex (fulvestrant) Chemotherapy Radiation Therapy Radiation Therapy Chemotherapy Chemotherapy Hormonal Therapy Tamoxifen pills (Nolvadex, Apo-Tamox, Tamofen, Tamone) Surgery Mastectomy: Right Surgery Hormonal Therapy Arimidex (anastrozole) Targeted Therapy Ibrance (palbociclib)

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