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All TopicsForum: DCIS plus HER2-positive Microinvasion → Topic: what does this mean regarding HER2?

Topic: what does this mean regarding HER2?

Forum: DCIS plus HER2-positive Microinvasion —

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Posted on: Feb 22, 2015 08:20PM

windingshores wrote:

My reading of this is that I am classified as HER2 positive but am close to being equivocal, but I could be reading it wrong. Will the FISH test mean I will be given herceptin? chemo? Is it urgent to get surgery asap? These are my main questions and I appreciate any help! (I see the MD in 3 days)


First, for a complete picture:

HER2/neu Protein performed on MS15-1690:

Equivocal (2+): Incomplete and/or weak to moderate circumferential membrane staining in >10% of tumor cells

Then FISH:

Clinical History: Calcifications and mass in right upper outer quadrant (my note: 1 cm IDC grade 3 w/pos. estrogen and prog.)

Interphase cells: >+20 Metaphase cells: 0

FISH Results

Positive for HER2 Amplification

HER2/D17Z1 ratio 2.1 (is the cut off 2.0? is this borderline?)

Average copy number signals/cell: HER2: 5.0, D17Z1: 2.4

Nomenclature: nuc ish (D17Z1x1-4, HER2x2-9) {>=20)

FISH assay revealed HER2 (ERBB2) amplification

Histopathological correlation is indicated

Assay Information:

a ratio of >/=2.0 or an average HER2 copy number >/=6.0 in 10% of tumor cells indicates amplification

a ratio of < 2.0 and an average HER2 copy number < 4.0 indicates absence of amplification

a ratio of < 2.0 and an average HER2 copy number per cell of >/= 4.0 and < 6.0 observed in a homogenous and contiguous population indicates an equivocal result for amplification


Dx 2/2015, DCIS/ILC/IDC, Right, 1cm, Stage IA, Grade 3, 0/3 nodes, ER+/PR+, HER2- (FISH) Surgery Lymph node removal; Mastectomy: Right Surgery Mastectomy: Left; Prophylactic mastectomy: Left Hormonal Therapy
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Aug 29, 2015 06:56AM - edited Aug 29, 2015 06:56AM by Lemint

Hi, Windingshores, I hope your your surgery went well. I noticed no one responded. I was originally diagnosed with DCID and after an MRI they said I had IDC mucinous carcinoma type. This type almost always is Her2 negative but mine came back Her2 positive. Now they say I must have chemo. My ratio was 2.7. Did you find out if your 2.1 ratio was borderline. Thx in advance.

Dx 7/21/2015, DCIS, Left, 1cm, Stage 0, Grade 2, ER+/PR- Dx 8/18/2015, IDC: Mucinous, Left, Stage IIB, Grade 1, 1/2 nodes, ER+/PR-, HER2+ Chemotherapy 12/2/2015 Carboplatin (Paraplatin), Taxotere (docetaxel) Targeted Therapy 12/2/2015 Perjeta (pertuzumab) Targeted Therapy 12/2/2015 Herceptin (trastuzumab) Radiation Therapy 4/10/2016
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Jan 11, 2018 11:35AM larajv wrote:

My FISH is 2.6. barely positive but positive. I've extensively researched HER2. Barely positive FiSH results maybe less responsive to targeted therapy (herceptin and Perjetta). Some people have FiSh in the upper teens. I'm proceeding with both of these targeted therapies. They are not chemo drugs, I can live with the side effects

Llv Dx 8/10/2017, IDC, Right, 3cm, Stage IIB, Grade 3, ER+/PR-, HER2+ (FISH) Chemotherapy 9/7/2017 AC + T (Taxol) Targeted Therapy Perjeta (pertuzumab)
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Jan 11, 2018 11:36AM larajv wrote:

My FISH is 2.6. barely positive but positive. I've extensively researched HER2. Barely positive FiSH results maybe less responsive to targeted therapy (herceptin and Perjetta). Some people have FiSh in the upper teens. I'm proceeding with both of these targeted therapies. They are not chemo drugs, I can live with the side effects

Llv Dx 8/10/2017, IDC, Right, 3cm, Stage IIB, Grade 3, ER+/PR-, HER2+ (FISH) Chemotherapy 9/7/2017 AC + T (Taxol) Targeted Therapy Perjeta (pertuzumab)

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