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All TopicsForum: Micro-invasive DCIS that is HER2 positive → Topic: DCIS, chek2+, negative receptors, high grade cells

Topic: DCIS, chek2+, negative receptors, high grade cells

Forum: Micro-invasive DCIS that is HER2 positive — Meet others with this diagnosis.

Posted on: Jun 10, 2017 11:48AM

Toughiebird wrote:

recent small spot, biopsy, lumpectomy at time of surgical biopsy - diagnoses small DCIS, high grade cells, chek2, negative receptors. Im 59 years and they are saying either radiation asap or bilateral mastectomy is on the table too. Im newly diagnosed, sister and family history of some breast and other cancers and need any advice.. Dr are not committing which is better treatment? meds tough i hear on negative receptors? Thank you

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Jun 11, 2017 04:49AM - edited Jun 11, 2017 05:05AM by BarredOwl

Hi Toughiebird:

I'm not clear on your diagnosis. This is a Forum for those with DCIS plus very small invasive breast cancers, where the invasive disease is HER2-positive:

>>Micro-invasive DCIS that is HER2 positive — Meet others with this diagnosis.

"Microinvasion" is an invasive Tumor ≤ 1 mm in greatest dimension. When microinvasion is present along with DCIS, it is sometimes referred to as "DCIS with microinvasion" ("DCIS-MI"). However, despite the name, the presence of invasion means that the diagnosis is invasive breast cancer (Stage IA or higher) and is no longer Stage 0 DCIS.

However, you only discussed some DCIS, and did not mention any microinvasion or the features of any invasive disease (ER, PR or HER2 status).

So, did you have pure DCIS or was some micro-invasion identified in your biopsy or surgery?

In case you had pure DCIS with no evidence of invasion (pure Stage 0 disease), then re your question: "meds tough i hear on negative receptors?":

(1) Pure DCIS (with no invasion) that is hormone-receptor negative (ER- PR-) is not typically treated with any drugs under current consensus guidelines.

(2) Pure DCIS (with no invasion) that is hormone-receptor positive (ER+ and/or PR+) may be treated with endocrine therapy (also referred to as anti-hormonal therapy) (e.g., Tamoxifen or possibly an Aromatase Inhibitor (for certain post-menopausal patients).

The above speaks to treatment of existing DCIS (Stage 0). Those who are considered to be at high risk for a new primary tumor (new diagnosis) due to a pathogenic mutation in a gene that confers a pre-disposition to breast cancer may receive a recommendation of endocrine therapy for the purpose of "chemoprevention".

Be sure to obtain complete copies of the pathology reports from all biopsies and surgeries for your review and records.

BarredOwl

Stage IA IDC, 9/2013 BMX. Right: IDC (1.5 mm, grade 2) with DCIS (5+ cm), 0/4 nodes, pN0. Left: DCIS (5+ cm), 0/1 node, pN0(i+).
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Jun 11, 2017 08:31AM Toughiebird wrote:

Thank you so much for responding. Your info is very helpful. i am new so probably on the wrong part of the site. No micro invasive diagnosed.

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Jun 11, 2017 08:52AM - edited Jun 11, 2017 09:09AM by BarredOwl

Hi Toughiebird:

If there was no invasion found, then the Forum for those with pure DCIS (Stage 0) is here:

DCIS (Ductal Carcinoma In Situ) - Just diagnosed, in treatment, or finished treatment for DCIS.

https://community.breastcancer.org/forum/68

Many find this post from Beesie regarding to be helpful:

A layperson's guide to DCIS (see original post in the thread):

https://community.breastcancer.org/forum/68/topics/790992?page=#post_3126898

For your other questions (lumpectomy plus radiation versus mastectomy), hopefully you will get some more replies to your post in the Positive Genetic Test Results forum.

Best,

BarredOwl

Stage IA IDC, 9/2013 BMX. Right: IDC (1.5 mm, grade 2) with DCIS (5+ cm), 0/4 nodes, pN0. Left: DCIS (5+ cm), 0/1 node, pN0(i+).

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