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Topic: confused by supplemental path report!

Forum: DCIS plus HER2-positive Microinvasion —

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Posted on: Jul 25, 2017 12:44PM

Annietere wrote:

I was diagnosed with DCIS grade 3, ER/PR negative, 2cm and one focus of microinvasion.  I had a mastectomy in May of 2016 and just received the supplemental path report.  The microinvasion was sent off for testing but none could be done due to size.  It was described as a "minute fragment of microinvasion" so no testing could be done.  In addition the DCIS, was found to be moderately staining for HER2 and the Ki67 was between 9 and 10%.  My questions are, why is the ki 67 low if the grade was 3?  is that possible?  What does moderate staining for HER mean?  Finally, should the microinvasion have been measured?  Is it normal for no measurement to be included in supplemental path report.   I would appreciate any information on this.  Thank you! 

DX with DCIS in April 2016- Grade 3, ER-/PR-, comedo type, 2.1cm. Underwent simple mastectomy in May 2016 and upgraded to T1mi when one focus smaller than 1mm found- too small to run tests on. 0/2 nodes.
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Jul 25, 2017 04:36PM ksusan wrote:

Ki67 measures the speed of proliferation, whereas the grade indicates the amount of damage. A low Ki67 with grade 3 may indicate that this was a slow-growing DCIS that you had for a long time.

Mutant uprising quashed. Dx 1/2015, IDC, Right, Stage IIA, 1/1 nodes, ER+/PR+, HER2- Dx 1/2015, DCIS, Left, Stage 0, Grade 3, 0/2 nodes Hormonal Therapy Tamoxifen pills (Nolvadex, Apo-Tamox, Tamofen, Tamone) Surgery Lymph node removal: Sentinel; Mastectomy: Left, Right Radiation Therapy Whole-breast Chemotherapy Cytoxan (cyclophosphamide), Taxotere (docetaxel)

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