Mar 10, 2012 02:35PM carol57 wrote:
My mom, her sisters, their mother and grandmother had BC. Mom is the only one who survived and is now 82. She refuses to have the test for reasons no one can decipher, so I was tested after my LCIS finding, because I wanted the information to help me decide if I would have oopherectomy, too. My pbmx decision was an easy one with the family history, and I knew I would go forward with that whether BRCA was positive or not.
I learned from the genetic counseling that we have a 50% chance of inheriting the mutation from a parent that has it. So IF your paternal grandmother or grandfather had it, then your dad had a 50% chance of inheriting it, and IF your dad did indeed inherit it, you have a 50% chance of inheriting it from him.
I am BRCA negative, and there's no BC history on my father's side, so my own son, daughter and granddaughter are in the clear, because their fathers have no BC family history.
My mother's refusal to have the test is causing a stir in family, because I have a brother and his children wonder about themselves and their own children.
If you are positive, your ovarian cancer odds are increased, so you might consider the test yourself even though your LCIS is already nudging you toward pmx. My insurance covered the test on the merits of my family history.
Here's what the Memorial Sloan Kettering Cancer Center site says about the chances of inheriting a BRCA mutation:
What are the chances of inheriting an altered BRCA1 or BRCA2 gene?
Both men and women can pass down a BRCA mutation. All people, whether they have cancer or not, have two copies of both BRCA genes - one copy from each parent. If you have a parent with a BRCA1 or BRCA2 mutation, you may inherit that parent's mutated (nonworking) BRCA gene, or you may inherit the working BRCA gene. In other words, you have a 50 percent chance of inheriting either copy of each parent's two BRCA genes. If you inherit a nonworking BRCA gene, you will have an increased risk for cancer. Even though you may inherit a working BRCA copy from the other parent, it takes only one altered BRCAgene to increase risk for breast or ovarian cancer. You also have a 50 percent chance of not inheriting a nonworking BRCA gene from a parent who carries a mutation. If that is the case you have the same risk for cancer as a person in the general population.
Here's the source for that paragraph:
Good luck with this--