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Topic: Breast cancer and melenoma. Related?

Forum: Genetic Testing —

ATM, BARD1, BRCA1, BRCA2, BRIP1, CDH1, CHEK2, NBN, NF1, PALB2, PTEN, RAD51C, RAD51D, STK11, TP53, and mismatch repair genes (MLH1, MSH2, MSH6, PMS2, EPCAM)

Posted on: Mar 1, 2015 10:30PM

stef58 wrote:

hello. I am a five breast cancer survivor I have never been tested for brca1 or2. But have read they can be related to melenoma. My brother has recently be diagnosed with stage 3 modular melenoma. Just wondering if anyone has any information on related mutations. Thanks stef5

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Mar 4, 2015 02:57PM stef58 wrote:

thanks. Kay. Read the article. It was helpful. I am going to talk to my oncologist about this one. Ste

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Apr 20, 2015 12:40AM - edited Apr 20, 2015 12:41AM by Sassy01

NE, I have been told by my oncologist that my BRCA2 puts me at a higher risk of melanoma. I have read this as well. I am actually going to a dermatologist next month for a full body scan due to some moles changing recently. There is a definite link to the BRCA mutation..

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Apr 20, 2015 12:50AM Pessa wrote:

I am BRCA 1 and 2 negative but had melanoma 21 years ago and BC 5 years ago.............

Dx 2/20/2010, IDC, <1cm, 0/3 nodes, ER+/PR-, HER2- Chemotherapy 5/5/2010 AC Surgery 10/22/2010 Lumpectomy: Right; Mastectomy: Right; Prophylactic mastectomy: Left Hormonal Therapy 11/20/2010 Arimidex (anastrozole)
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Apr 20, 2015 04:25AM Traveltext wrote:

I know a guy who had a melanoma removed from his back and the an MRI afterwardsfound he had breast cancer. He has just had a mastectomy.

NED breast and prostate cancer. More on Male BC

Dx 03/14, IBC, Lgth. 2cm, Stge IIIB, Gde 2B, ER+/PR+, HER2- ; FEC x3, Taxol x3; Mx & 2/23 nodes; Rads x 33; now on tamoxofin.

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Apr 21, 2015 09:23PM new2bc wrote:

My dermatologist told me there is a link between breast cancer and melanoma. He told me to do a full body check in his office.

http://www.skincancer.org/skin-cancer-information/...


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Apr 22, 2015 06:39AM cp418 wrote:

http://www.cancerresearchuk.org/about-cancer/cance...

Here is one link regarding multiple genes. I'm trying to find the other link which had a spreadsheet table listing the gene mutations across cancers. It showed for example, a particular gene associated with breast cancer, melanoma and colon cancer risk.

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Apr 22, 2015 06:57AM geewhiz wrote:

I think somewhere there is a genetic/environmental component to my family's problems. My 45 year old sister has melanoma and she has dark hair and medium skin - so what are the odds that both of us would get a malignancy? My dad has prostate cancer, my uncle died of stomach cancer at age 40, and my grandparents died of cancer (stomach and ovarian). They live in a farming community on land in the family since the 1700's, The chemicals those companies dump on our food crops by the hundreds of gallons is staggering. I think the water table has gotten poisoned and our DNA damaged.

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Apr 22, 2015 04:18PM dlb823 wrote:

I believe there's a genetic link in at least some instances. Lots of cancer in my family -- sister and I both bc; 2 first cousins w/bc; Dad colon cancer, and a few of his many siblings had various cancers; and my brother had a melanoma removed from his leg. No BRCA or other known mutation, but I'd be shocked if that much cancer was coincidental.

Deanna "The soul would have no rainbow if the eyes had no tears" Native American proverb Dx 2/1/2008, 1cm, Stage IIA, Grade 3, 1/16 nodes, ER+/PR+, HER2- Dx 1/3/2014, Stage IV
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Apr 22, 2015 04:24PM fizzdon52 wrote:

I have heard of a connection of BC and having lots of moles, and having lots of moles leaves you open to melanoma? - if that makes sense.

Dx 2/8/2014, ILC, Right, 3cm, Grade 2, 0/11 nodes, ER+/PR+, HER2- Surgery 4/29/2014 Lumpectomy: Right; Lymph node removal: Right, Underarm/Axillary Radiation Therapy 5/31/2014 Whole-breast: Breast Hormonal Therapy 6/30/2014 Tamoxifen pills (Nolvadex, Apo-Tamox, Tamofen, Tamone)
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Apr 22, 2015 07:17PM Bren-2007 wrote:

New2bc ... Thanks for posting that link. I have had skin cancer regularly removed since I was 29. The link you posted commented that there was a 29% greater risk of melanoma in breast cancer patients. That scares me, as well as the genetic component. In my immediate family, we have breast, colon, melanoma, basal cell skin cancer, pancreatic and esophageal cancer.

I have regular full body checks by my dermatologist every six months and she checks every single sq. inch of skin. It sucks ... she's always burning or cutting something off of me.

Bren

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Feb 9, 2017 01:22PM stef58 wrote:

hello. Just wanted to update this post. I had genetic testing it came back negative. The counselor thought it was interesting how my family seems to have many with some type of cancer. I think we have a bad gene in my family but they have not found it. Since this postvhave had close family pop up with cancer of different types. But everyone is doing great. Ste

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Feb 9, 2017 07:06PM Pessa wrote:

Glad everyone is doing well.

Dx 2/20/2010, IDC, <1cm, 0/3 nodes, ER+/PR-, HER2- Chemotherapy 5/5/2010 AC Surgery 10/22/2010 Lumpectomy: Right; Mastectomy: Right; Prophylactic mastectomy: Left Hormonal Therapy 11/20/2010 Arimidex (anastrozole)
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Feb 9, 2017 07:48PM MinusTwo wrote:

I have had 5 basal cell skin cancers removed starting when I was 25. I'm scheduled for 6 month full body checks with my derm doc. She always freezes at 10-15 pre-cancers. And maybe once a year I end up with a biopsy. This has been standard for more than 20 years.
Interesting that the first full body scan after chemo, she said my skin was gorgeous. No pre-cancerous lesions, no problems. I told her that she probably didn't want to recommend the treatment to her other patients.

Even though this thread is old, thanks for the info that skin cancer may be related. I'll certainly ask my derm doc when I see her the end of the montn.

2/15/11 BMX-DCIS 2SNB clear-TEs; 9/15/11-410gummies; 3/20/13 recurrance-5.5cm,mets to lymphs, Stage IIIB IDC ER/PRneg,HER2+; TCH/Perjeta/Neulasta x6; ALND 9/24/13 1/18 nodes 4.5cm; AC chemo 10/30/13 x3; herceptin again; Rads Feb2014

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