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Topic: BRCA- patients might still have BRCA+ signature in their tumors!

Forum: Genetic Testing —

ATM, BARD1, BRCA1, BRCA2, BRIP1, CDH1, CHEK2, NBN, NF1, PALB2, PTEN, RAD51C, RAD51D, STK11, TP53, and mismatch repair genes (MLH1, MSH2, MSH6, PMS2, EPCAM)

Posted on: Mar 13, 2017 05:27PM

ChiSandy wrote:

Just because your genetic testing (blood or saliva) came back negative for genetic mutations doesn't mean that BRCA mutations don't affect you:

BRCA+ signatures in up to half the tumors of some BRCA- patients?

The article on the GenomeWeb site, citing a study reported in Nature Today, suggests that more patients than previously thought might benefit from further tumor analysis and PARP-inhibitor therapy. Might there be additional criteria added to common tumor-cell genomic tests?

Diagnosed at 64 on routine annual mammo, no lump. OncotypeDX 16. I cried because I had no shoes...but then again, I won’t get blisters.... Dx 9/9/2015, IDC, Right, 1cm, Stage IA, Grade 2, 0/4 nodes, ER+/PR+, HER2- (IHC) Surgery 9/23/2015 Lumpectomy: Right Radiation Therapy 11/2/2015 3DCRT: Breast Hormonal Therapy 12/31/2015 Femara (letrozole)
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