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Topic: TNBC and BRCA1+

Forum: Genetic Testing —

ATM, BARD1, BRCA1, BRCA2, BRIP1, CDH1, CHEK2, NBN, NF1, PALB2, PTEN, RAD51C, RAD51D, STK11, TP53, and mismatch repair genes (MLH1, MSH2, MSH6, PMS2, EPCAM)

Posted on: Nov 7, 2017 11:23AM

shaneswife828 wrote:

Hello ladies, I am a 32 year old momma of six. I have Stage 1a Grade 3 TNBC. I have underwent a bilateral mastectomy and nodes were negative. There was no lymphovascular invasion and other than the mass there was no other signs of cancer in my breast tissue. I will be starting chemo this Friday. I will be doing 4DD A/C which my doctor wants to follow with 4DD Taxol. I have done a ton of research and have found that Taxol can pose more harm than good in BRCA1 TNBC. The research has showed that BRCA1 TNBC is fairly resistant to Taxanes. Because of this I am considering forgoing the Taxol. Has anyone here done just the A/C? I asked about carboplatin but my oncologist said they usually only use that with stage 3. Many women with stage 2 and 3 have done the same treatment I am going to be doing. His words were that all 8 are likely over kill and I can do as little or as much of the chemo as I want. Any and all opinions would be so very helpful.

Crystal Dx 8/22/2017, IDC, Left, 1cm, Stage IA, Grade 3, 0/3 nodes, ER-/PR-, HER2- Surgery 9/18/2017 Lymph node removal: Sentinel; Mastectomy: Left, Right; Prophylactic mastectomy: Right; Reconstruction (left): Tissue expander placement; Reconstruction (right): Tissue expander placement Chemotherapy 11/14/2017 AC + T (Taxol)
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Nov 17, 2017 01:21PM Singapore75 wrote:


I am 42 years old, BRCA1 and TNBC carrier. I finished my chemo 8 weeks ago and waiting to do double mastectomy in December. My chemo regimen was 3 cycles of FAC and 12 weekly doses of taxol and Carboplatin. I don't know about taxol resistance or harmful for TNBC but I know taxol better do with TNBC. I felt better with taxol Carboplatin than FAC.

Wishing you good luck for this journey.

DX: 3/11/2017, IDC, 1.9 cm, stage 2, grade 3, 1/26 node, triple negative. Surgery: Lumpectomy 3/16/2017, Chemo: FAC 3 cycle, 12 weekly doses of Taxol & Carboplatin

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