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Help with Abbreviations

Topic: Genomic Testing

Forum: Genetic Testing —

ATM, BARD1, BRCA1, BRCA2, BRIP1, CDH1, CHEK2, NBN, NF1, PALB2, PTEN, RAD51C, RAD51D, STK11, TP53, and mismatch repair genes (MLH1, MSH2, MSH6, PMS2, EPCAM)

Posted on: Aug 6, 2020 04:55PM

NorCalS wrote:

When I was diagnosed with TBNC in June of 2019, I qualified for genetic testing under Kaiser Permanente’s guidelines. I tested negative for various genetic mutations. I recently learned that genomic testing is used to determine characteristics of the cancer cells. When I asked my oncologist if I could get genomic testing she did not recommend it because she said there was little that the results would not alter my treatment plan. Can someone explain the value of genomic testing to their treatment plan and how they got their oncologist to order a genomic tests.


Any input is much appreciated

Dx: 06/2019, left breast, ER/PR-, Her2-. Treatment: 06/2019 - 11/2019 AC/T. Surgery: Lumpectomy with axillary dissection in 12/2019. Radiation: 01/2020-03/2020. Xeloda - 03/2020-09/2020
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Aug 6, 2020 05:45PM MelissaDallas wrote:

Oncotype or Mammaprint help determine whether hormone receptor positive breast cancer patients would benefit or not from chemo. Since you were triple negative you needed chemo since endocrine therapy wouldn’t help.

Tests like Foundation One are most often used for advanced or Stage IV cancer where often various treatments have failed already to see if there are possibly particular immunological treatments or other agents, etc that might be succesful against that patient’s particular cancer genetic makeup.

LCIS, extensive sclerosing adenosis, TAH/BSO & partial omentectomy for mucinous borderline ovarian tumor.
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Aug 7, 2020 12:15AM NorCalS wrote:

Thanks Melissa.

I have late stage TNBC (stage 3c under old staging guidelines and stage 4 under newer staging Guidelines). I did not get PCR after neoadjuvent chemo and surgery. I am on Xeloda now to help prevent a recurrence. It seems like we are just taking a shot with Xeloda without really knowing whether it will be effective

Dx: 06/2019, left breast, ER/PR-, Her2-. Treatment: 06/2019 - 11/2019 AC/T. Surgery: Lumpectomy with axillary dissection in 12/2019. Radiation: 01/2020-03/2020. Xeloda - 03/2020-09/2020

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