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Topic: Lynparza Offers Benefits for Early-Stage HER2- BRCA+

Forum: Genetic Testing —

ATM, BARD1, BRCA1, BRCA2, BRIP1, CDH1, CHEK2, NBN, NF1, PALB2, PTEN, RAD51C, RAD51D, STK11, TP53, and mismatch repair genes (MLH1, MSH2, MSH6, PMS2, EPCAM)

Posted on: Jun 17, 2021 06:34PM

Moderators wrote:

Lynparza Offers Benefits for Early-Stage HER2-Negative Breast Cancer With BRCA1/2 Mutation
June 10, 2021

Adding Lynparza to standard treatment for early-stage HER2-negative breast cancer with a high risk of recurrence in people with a BRCA1 or BRCA2 mutation improved disease-free survival. Read more...

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Jun 17, 2021 07:01PM 2019whatayear wrote:

I wonder, did they break out HR + results b/c almost 90% of the participants were HR- so we’re the results as good for HR + as for HR

5/6/2019 IDC 2cm, micromet 1/9 nodes, BRCA2+, ER+, PR+, HER- BMX 6/2019, A/C & Taxol 2019, Radiation, BSO - preventative 2/2020, Letrozole 3/1/2020, Started Lynparza for 1 year preventative on 7/18/2021
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Jun 17, 2021 08:27PM Moderators wrote:

2019whatayear -- this is what our editorial department had to say about your question:

They didn't break out the results that way because the number of people with hormone-receptor-positive breast cancer and the number of people with hormone-receptor-negative breast cancer were about the same in each treatment group.

Does that help?

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Jun 17, 2021 10:11PM 2019whatayear wrote:

thanks for the reply, what am I misunderstanding?

5/6/2019 IDC 2cm, micromet 1/9 nodes, BRCA2+, ER+, PR+, HER- BMX 6/2019, A/C & Taxol 2019, Radiation, BSO - preventative 2/2020, Letrozole 3/1/2020, Started Lynparza for 1 year preventative on 7/18/2021
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Jun 17, 2021 10:49PM 2019whatayear wrote:

Speaking of this drug,This was just released by ASCO:

https://www.asco.org/about-asco/press-center/news-releases/asco-releases-rapid-guideline-recommendation-update-certain

5/6/2019 IDC 2cm, micromet 1/9 nodes, BRCA2+, ER+, PR+, HER- BMX 6/2019, A/C & Taxol 2019, Radiation, BSO - preventative 2/2020, Letrozole 3/1/2020, Started Lynparza for 1 year preventative on 7/18/2021
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Jun 26, 2021 07:57PM Moderators wrote:

We believe that the paragraph you noted simply explains who was involved in the study, not who benefited from the study, since the benefits were the same or similar among HR+ and HR-. Does that make sense?

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Jun 26, 2021 11:56PM 2019whatayear wrote:

yes that makes sense

5/6/2019 IDC 2cm, micromet 1/9 nodes, BRCA2+, ER+, PR+, HER- BMX 6/2019, A/C & Taxol 2019, Radiation, BSO - preventative 2/2020, Letrozole 3/1/2020, Started Lynparza for 1 year preventative on 7/18/2021

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