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Topic: CHEK2 gene

Forum: Genetic Testing —

ATM, BARD1, BRCA1, BRCA2, BRIP1, CDH1, CHEK2, NBN, NF1, PALB2, PTEN, RAD51C, RAD51D, STK11, TP53, and mismatch repair genes (MLH1, MSH2, MSH6, PMS2, EPCAM)

Posted on: Aug 11, 2021 02:23PM

GrandmaNancy wrote:

I am 70 years old. I was first diagnosed with breast cancer 18 years ago. I had a lumpectomy followed be radiation. After18 years, I thought I was worry free.

Three years ago I had genetic testing & discovered that I have the CHEK2 gene. Recently I tested positive for cancer in my other breast. It’s DCIS stage 0.I’m going for a lumpectomy next week. Has anyone else had cancer in their other breast after so many years? If so, did you opt for bilateral mastectomy?

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Aug 14, 2021 12:23PM Moderators wrote:

BUMP for GrandmaNancy -- can anyone weigh in?

To send a Private Message to the Mods: community.breastcancer.org/mem...
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Aug 14, 2021 01:07PM jennyjo20 wrote:

Hi Grandma Nancy,

I’m too early in the process to answer your exact question, but I also have the CHEK2 mutation. The genetic counselors did warn me that I’m at increased risk for a second primary. I’m sorry you find yourself in this situation but glad it was detected while still stage 0 DCIS.

Diagnosed at 42 - Oncotype 24; CHEK2 mutation Dx 2/2020, IDC, Right, 1cm, Stage IB, Grade 2, 1/5 nodes, ER+/PR+, HER2- (FISH) Surgery 3/18/2020 Lumpectomy: Right; Lymph node removal: Sentinel Chemotherapy 4/17/2020 Abraxane (albumin-bound or nab-paclitaxel), Cytoxan (cyclophosphamide) Hormonal Therapy 7/6/2020 Zoladex (goserelin) Radiation Therapy 7/13/2020 Whole-breast: Breast, Lymph nodes Hormonal Therapy 8/17/2020 Tamoxifen pills (Nolvadex, Apo-Tamox, Tamofen, Tamone) Hormonal Therapy 1/6/2021 Arimidex (anastrozole)
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Aug 14, 2021 04:28PM Esther01 wrote:

Hi Grandma Nancy,

I"m so sorry this happened again after 18 years. I pray that your upcoming lumpectomy (or mastectomy if you choose) and any additional treatment are successful as your original treatment was. I have the same CHEK2 gene. I am going through radiation now for what I hope will be the only occurrence, but I do understand that gene mutations can make recurrence more likely. I didn't want a mastectomy because I had read a few studies that it could still come back and that lumpectomy was preferred for low grade/stage, but others here will certainly be more of an expert on that than me.

I am learning lately that there is much more to genetics than the existence of a genetic mutation, and that certain lifestyle and external factors can affect our genes (epigenetics) in a way such that the genetic expression is effectively turned on or off. I'm only beginning to learn about the metabolic characteristics of cancer, but it is my understanding from specialists in the field like geneticist/biochemist Dr. Seyfried and others who have done many studies that cancer cells survive by fermenting glucose and glutamine and that some things such as a keto diet (keeping your body in ketosis) and increased exercise/oxygen to the tissues are just a few ways to help make our bodies less hospitable to a new cancer growth.

Also, are you blood type A? If so, you may definitely want to increase digestive enzymes. Please feel free to message me if you'd like any information on enzymes.

I am so sorry for the new occurrence and I hope that you are through treatment as comfortably as possible and on your way to recovery very soon.

Blessings to you,

Esther

Grateful to Jesus, that His love finally broke through to me. "With one touch, You just rolled away the stone that held my heart," - Lyrics by Keith Green, " 7 weeks of Radiation including supraclavicular nodes. Dx 12/2020, IDC, Stage IIB, 5/11 nodes, ER+/PR+, HER2- Hormonal Therapy 12/19/2020 Tamoxifen pills (Nolvadex, Apo-Tamox, Tamofen, Tamone) Surgery 6/8/2021 Lumpectomy; Lymph node removal: Sentinel; Reconstruction (left) Radiation Therapy 8/3/2021 Whole-breast: Breast, Lymph nodes
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Aug 14, 2021 05:20PM GrandmaNancy wrote:

hi Esther01.

Thank you for your response. I had a stereotactic biopsy yesterday. We are hoping the results come in before my scheduled lumpectomy on Tuesday. I initially had a US guided biopsy on a spot that showed up on my ultrasound, but my mammogram showed a different spot. The radiologist insisted on the second biopsy.

I have mostly consumed a very healthy diet - little to no processed food & sweets, grass fed beef occasionally, organic, nonGMO most of the time. I am currently reading a book on autophagy which touts scientific research on the topic. In a nutshell, it’s the “process by which cells remove toxins, recycle parts, and repair their own damage”. The author suggests that this lifestyle can “suppress systems & processes that can be related to the development of cancer”. I’m eager to finish reading and perhaps embark on a new, healthier lifestyle.

I will share my biopsy & surgery results when I have them.

GrandmaNamc

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Aug 14, 2021 05:24PM - edited Aug 14, 2021 05:24PM by Aram

Esther01, the research has not shown positive effects of exercise or diet on people with genetic predisposition to breast cancer or even in case of Her2+ BC. Breast cancer is not one single disease and something that might be true for one time doesn't necessarily mean it's true for other types.

GrandmaNancy, my aunt had two different primaries about 20 years apart and is not with us anymore. She wasn't a confirmed BRCA1 case but considering the info we have now she is presumed to have been BRCA1 positive. The genetic counselor told me I also have a very high chance of getting a second primary therefore BMX for me is in the plan.

Dx at 40, BRCA1 Dx 2/5/2021, IDC, Left, 1cm, Grade 3, ER-/PR-, HER2+ (IHC) Dx 2/5/2021, IDC, Left, 3cm, Grade 3, ER-/PR-, HER2+ (IHC) Chemotherapy 3/9/2021 AC + T (Taxol) Targeted Therapy 6/1/2021 Herceptin (trastuzumab) Targeted Therapy 6/2/2021 Perjeta (pertuzumab) Surgery 10/6/2021 Mastectomy: Left; Prophylactic mastectomy: Right; Reconstruction (left); Reconstruction (right)
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Aug 14, 2021 06:18PM Esther01 wrote:

Thanks Aram,

Fortunately, there are oncologists and researchers in the field of cancer treatment who are far more informed than we are who are indeed successfully working with cancer survivors with the same genetic mutation that I have. Whether their patient success stories are anecdotal or published in peer-reviewed journals, there is not a person alive on the planet who will not benefit from diet and exercise.

Blessings,

Esther

Grateful to Jesus, that His love finally broke through to me. "With one touch, You just rolled away the stone that held my heart," - Lyrics by Keith Green, " 7 weeks of Radiation including supraclavicular nodes. Dx 12/2020, IDC, Stage IIB, 5/11 nodes, ER+/PR+, HER2- Hormonal Therapy 12/19/2020 Tamoxifen pills (Nolvadex, Apo-Tamox, Tamofen, Tamone) Surgery 6/8/2021 Lumpectomy; Lymph node removal: Sentinel; Reconstruction (left) Radiation Therapy 8/3/2021 Whole-breast: Breast, Lymph nodes
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Aug 14, 2021 06:22PM Esther01 wrote:

GrandmaNancy,

Let us know how it goes! That book sounds wonderful. I would love to read it. This has been such a steep learning curve in the past seven months.

Blessings on your weekend,

Esther

Grateful to Jesus, that His love finally broke through to me. "With one touch, You just rolled away the stone that held my heart," - Lyrics by Keith Green, " 7 weeks of Radiation including supraclavicular nodes. Dx 12/2020, IDC, Stage IIB, 5/11 nodes, ER+/PR+, HER2- Hormonal Therapy 12/19/2020 Tamoxifen pills (Nolvadex, Apo-Tamox, Tamofen, Tamone) Surgery 6/8/2021 Lumpectomy; Lymph node removal: Sentinel; Reconstruction (left) Radiation Therapy 8/3/2021 Whole-breast: Breast, Lymph nodes
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Aug 14, 2021 09:10PM GrandmaNancy wrote:

Esther01

Thank you Esther01. Blessings to you too!

Nancy

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Aug 14, 2021 09:27PM K-Gobby wrote:

I was genetically tested 2 days ago and have BRCA2. My dosage changed and today i had my first infusion with 11 more done on every Friday. I am wondering now which one will get me. I am taking the nausea pills as described. Cutting my hair on Monday at 9am and meeting with the breast surgeon and the Gyno surgeon. With my gene, and my families cancer history, the Brest and women's parts are loved by this cancer gene. If i had a prostate, it would have went there. A little humor will keep us on the road to better health.

Grandma Nancy- I hope it is a diagnosis that can be worked with. Cancer Doctors in 2021 are good. They have not stopped my testing since the 20th of July when i met the team.

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Aug 16, 2021 10:56AM GrandmaNancy wrote:

K Gobby

Praying for positive results from your treatments.

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