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Topic: Genetic study at New York Presbyterian

Forum: Genetic Testing —

ATM, BARD1, BRCA1, BRCA2, BRIP1, CDH1, CHEK2, NBN, NF1, PALB2, PTEN, RAD51C, RAD51D, STK11, TP53, and mismatch repair genes (MLH1, MSH2, MSH6, PMS2, EPCAM)

Posted on: Oct 22, 2021 11:11PM - edited Oct 23, 2021 01:18PM by Reckless

Reckless wrote:

This Post was deleted by Reckless.
πŸ’‰πŸ’‰πŸ’‰ Dx 3/4/2016, IDC, Right, 2cm, Stage IA, Grade 2, 0/2 nodes, ER+/PR+, HER2- Surgery 4/19/2016 Mastectomy: Right; Prophylactic mastectomy: Left; Reconstruction (left): Tissue expander placement; Reconstruction (right): Tissue expander placement Hormonal Therapy 6/19/2016 Tamoxifen pills (Nolvadex, Apo-Tamox, Tamofen, Tamone) Surgery 8/11/2016 Reconstruction (left): Silicone implant; Reconstruction (right): Silicone implant Surgery 11/14/2017 Prophylactic ovary removal Hormonal Therapy 6/20/2018 Arimidex (anastrozole)
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Oct 22, 2021 11:58PM - edited Oct 23, 2021 01:18PM by Reckless

This Post was deleted by Reckless.
πŸ’‰πŸ’‰πŸ’‰ Dx 3/4/2016, IDC, Right, 2cm, Stage IA, Grade 2, 0/2 nodes, ER+/PR+, HER2- Surgery 4/19/2016 Mastectomy: Right; Prophylactic mastectomy: Left; Reconstruction (left): Tissue expander placement; Reconstruction (right): Tissue expander placement Hormonal Therapy 6/19/2016 Tamoxifen pills (Nolvadex, Apo-Tamox, Tamofen, Tamone) Surgery 8/11/2016 Reconstruction (left): Silicone implant; Reconstruction (right): Silicone implant Surgery 11/14/2017 Prophylactic ovary removal Hormonal Therapy 6/20/2018 Arimidex (anastrozole)
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Oct 23, 2021 05:52AM Jelson wrote:

Reckless - I note you mention that the NYP study includes pathways for medication uptake. I don't think 23andMe covers it well if at all. Pharmacokinetics/Pharmagenetics are some of the terms used in this area and the papers/clinical studies are way beyond my comprehension. There has been in the past much discussion on BCO whether the metabolic pathways for tamoxifen are the reason it helps some BC patients better than others and why certain SSRIs also seem to impact the effectiveness of tamoxifen. I think Cyp2D6 refers to the pathway for tamoxifen. This issue of how individual genetics impacts how we react to drugs and the interaction of drugs which follow the same metabolic pathways applies to many of the drugs BC patients and actually anyone takes. Depending on how detailed the NYP study is and how much they share with you about your results, this could be valuable info for you going forward with medication prescribed for conditions other than BC.

Dx 4/17/2009, DCIS, <1cm, Stage 0, Grade 3, 0/0 nodes, ER+/PR+
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Oct 23, 2021 10:22AM - edited Oct 23, 2021 01:18PM by Reckless

This Post was deleted by Reckless.
πŸ’‰πŸ’‰πŸ’‰ Dx 3/4/2016, IDC, Right, 2cm, Stage IA, Grade 2, 0/2 nodes, ER+/PR+, HER2- Surgery 4/19/2016 Mastectomy: Right; Prophylactic mastectomy: Left; Reconstruction (left): Tissue expander placement; Reconstruction (right): Tissue expander placement Hormonal Therapy 6/19/2016 Tamoxifen pills (Nolvadex, Apo-Tamox, Tamofen, Tamone) Surgery 8/11/2016 Reconstruction (left): Silicone implant; Reconstruction (right): Silicone implant Surgery 11/14/2017 Prophylactic ovary removal Hormonal Therapy 6/20/2018 Arimidex (anastrozole)

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