Topic: Brca 1 Mutation and the Vaginal Microbiome/gut microbiome

Forum: Genetic Testing — ATM, BARD1, BRCA1, BRCA2, BRIP1, CDH1, CHEK2, NBN, NF1, PALB2, PTEN, RAD51C, RAD51D, STK11, TP53, mismatch repair genes (MLH1, MSH2, MSH6, PMS2, EPCAM), and VUS (variants of unknown significance)

Posted on: Nov 25, 2022 03:34PM

Posted on: Nov 25, 2022 03:34PM

kayrem wrote:

Hi. I just came across this interesting article today.

https://www.ucl.ac.uk/news/2019/jul/vaginal-bacteria-linked-ovarian-cancer

I just did a google search because i have a lot of allergies and I am asthmatic and I often have had to take steroids, both oral and nasal, over my lifetime. I recently (last Sunday) started taking Flonase because the doctor saw a bit of fluid in my ear canal and thought it would help. It is a nasal steroid. I told him I did not want to take it because I always got thrush in my mouth when I took steroids. He said there is no way a nasal steroid would give me thrush, my husband said the same thing. Well Friday morning, 5 days after starting them (I even cut my dose down to 1/2 the amount last night since they were working so nicely), I got thrush!

So I was telling my husband that I wondered if it was the Brca 1 mutation gene that was causing a problem with yeast in me! He said no way. He thought it had to do with my (first time ever!) slightly high H1bc number. But then I remembered that I had yeast infections almost every month when I was a teen up until my 30’s when I went on an Atkinson diet for 1 year or so, so I could lose weight.I have no clue why but the Atkinson diet killed my yeast infection problem for good. I wonder if the Brca 1 mutation messes with our gut microbiome also. I found an article that said BRCA1 mutations had “different microbiomes” than non BRCA1 mutations but the is all I can find. I am 57 now and had all my prophy procedures done around 10 years ago. I am pretty happy I did that after reading this article.

I am wondering if any other BRCA1 mutation carriers have had as many issues with yeast and yeast infections over their lifetime’s also?


Dx 6/13/2011, IDC, 2cm, Stage IIIA, Grade 3, 4/11 nodes, ER-/PR-, HER2- Surgery 6/30/2011 Lumpectomy; Lumpectomy (Right) Chemotherapy 9/15/2011 Cytoxan (cyclophosphamide), Ellence (epirubicin), Fluorouracil (5-fluorouracil, 5-FU, Adrucil), Taxol (paclitaxel) Radiation Therapy 2/21/2012 Breast, Lymph nodes Surgery 3/14/2013 Prophylactic mastectomy; Prophylactic mastectomy (Left); Prophylactic mastectomy (Right) Surgery 5/21/2013
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Nov 25, 2022 03:45PM kayrem wrote:

One more article from Nature.

https://www.nature.com/articles/d41586-021-03716-8

Dx 6/13/2011, IDC, 2cm, Stage IIIA, Grade 3, 4/11 nodes, ER-/PR-, HER2- Surgery 6/30/2011 Lumpectomy; Lumpectomy (Right) Chemotherapy 9/15/2011 Cytoxan (cyclophosphamide), Ellence (epirubicin), Fluorouracil (5-fluorouracil, 5-FU, Adrucil), Taxol (paclitaxel) Radiation Therapy 2/21/2012 Breast, Lymph nodes Surgery 3/14/2013 Prophylactic mastectomy; Prophylactic mastectomy (Left); Prophylactic mastectomy (Right) Surgery 5/21/2013

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