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Topic: Prolia Lowers Risk of Breaking Bones in Women Taking AIs

Forum: Bone Health and Bone Loss —

Talk with others about bone density, osteopenia and osteoporosis, and ways to keep your bones strong

Posted on: Jun 18, 2015 03:16AM

Moderators wrote:

A recent study has found that Prolia reduced the risk of breaking a bone by 50% in postmenopausal women diagnosed with early-stage, hormone-receptor-positive breast cancer who were taking an aromatase inhibitor.

June 10, 2015.

Read more here: http://www.breastcancer.org/research-news/prolia-lowers-bone-breaks-for-ai-takers

To send a Private Message to the Mods: community.breastcancer.org/mem...
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Oct 11, 2015 06:24AM Golden01 wrote:

Any one switched to Prolia because of this study? My MO just called with the results of my most recent DEXA (worse but still osteopenic) but did not recommend going on Prolia at this time. His reason seemed to be cost (I have good insurance and am confident it will be covered). If not, I've always gotten my appeals approved!

Mucinous Carcinoma, Hypercellular Variant; Oncotype DX 27, Dx 7/8/2011, <1cm, Stage I, Grade 2, 0/3 nodes, ER+/PR-, HER2- Hormonal Therapy 7/19/2014 Arimidex (anastrozole)
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Oct 11, 2015 01:24PM - edited Oct 11, 2015 01:41PM by Kathy044

Will add my personal story about taking Prolia on the bone forum later Golden (Thanksgiving weekend here in Canada).

Mods the BCO report of the ABCSG-18 study above is based on the wording presented at the ASCO meeting which as it happens is slightly different to the wording of the published Lancet study summary. I was wondering why ASCO dropped the mention of one death in the denosumbab group that might have been related to the drug, because it was not proven? But then why the mention in the Lancet summary? Also I guess I've been reading too many biopsy reports but since when is an interpretation of a finding a conclusion.

www.thelancet.com/journals/lan...

Kathy
Dx 2009, ILC, Right, 1cm, Stage IIA, Grade 2, 1/15 nodes, ER+/PR+, HER2- Surgery 10/28/2009 Lumpectomy: Right; Lymph node removal: Right, Underarm/Axillary Chemotherapy 12/15/2009 Cytoxan (cyclophosphamide), Ellence (epirubicin), Fluorouracil (5-fluorouracil, 5-FU, Adrucil), Taxotere (docetaxel) Radiation Therapy 5/1/2010 Whole-breast: Breast Hormonal Therapy 6/3/2010 Arimidex (anastrozole)
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Oct 12, 2015 11:52AM Golden01 wrote:

Hmmm . . . as I read the abstracts, the study looked at AIs and Prolia, are there other studies that have an arm where women were on Fosamax? Not sure it matters since I've been on Fosamax and my DEXA scores got worse. MO is not recommending change to Prolia at this time but it seems we need to do something different!


Mucinous Carcinoma, Hypercellular Variant; Oncotype DX 27, Dx 7/8/2011, <1cm, Stage I, Grade 2, 0/3 nodes, ER+/PR-, HER2- Hormonal Therapy 7/19/2014 Arimidex (anastrozole)
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Oct 12, 2015 07:25PM Jerseygirl927 wrote:

I was diagnosed with osteopenia years ago, was on fozamax for a few years, until it gave me acid reflux. The fozamax worked but went off of it because of the GERD, took other drugs, protonix etc, still showed osteopenia in more scans, then in 2013 fell and fractured 5 different bones so another bone scan still showed osteopenia, but since I fractured decided to go with prolia shot after discussion with my dentist and gyn. Had first shot last Thursday so next one will be in 6 months.

Surgery 1/12/2015 Lymph node removal: Left, Sentinel; Mastectomy: Left, Right Dx 1/14/2015, ILC/IDC, Left, 1cm, Stage IA, Grade 1, 0/5 nodes, ER+/PR+, HER2+ Chemotherapy 2/25/2015 Carboplatin (Paraplatin), Taxol (paclitaxel) Hormonal Therapy 5/29/2015 Femara (letrozole) Dx IDC, ER+/PR+, HER2+ Dx ILC, 1cm, Stage IA, 0/1 nodes, ER+/PR+, HER2+
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Dec 24, 2015 05:42AM - edited Dec 24, 2015 02:04PM by Golden01

Saw my MO yesterday, he is going to request insurance approval for me to switch from Fosamax to Prolia. My bones have gotten worse since going on Arimidex a year and a half ago. Any suggestions for making it go well? Hearing about your experience with Prolia will be helpful to me!


Mucinous Carcinoma, Hypercellular Variant; Oncotype DX 27, Dx 7/8/2011, <1cm, Stage I, Grade 2, 0/3 nodes, ER+/PR-, HER2- Hormonal Therapy 7/19/2014 Arimidex (anastrozole)
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Dec 27, 2015 08:42PM Jerseygirl927 wrote:

no side effects with the prolia shot, so far so good, have not been on anastrozole long enough to know if this has any ill effects on bone density. Hope not! Do have a tooth issue, so going to talk to dr about it soon. My MO still suggests vitamin d and calcium to help aid the bone growth.


Surgery 1/12/2015 Lymph node removal: Left, Sentinel; Mastectomy: Left, Right Dx 1/14/2015, ILC/IDC, Left, 1cm, Stage IA, Grade 1, 0/5 nodes, ER+/PR+, HER2+ Chemotherapy 2/25/2015 Carboplatin (Paraplatin), Taxol (paclitaxel) Hormonal Therapy 5/29/2015 Femara (letrozole) Dx IDC, ER+/PR+, HER2+ Dx ILC, 1cm, Stage IA, 0/1 nodes, ER+/PR+, HER2+
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Dec 28, 2015 01:03PM cp418 wrote:

I had my first Prolia injection a few weeks ago and much prefer it over IV Zometa infusions (I have terrible veins to start IV). I was dx with osteopenia after 2 years on Femara and if I recall had approx 8 Zometa infusions over the years. I'm really hoping Prolia will make a difference in my bone health.

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Dec 28, 2015 05:50PM Golden01 wrote:

Thanks for the info! I'll keep my fingers crossed as the request goes to the insurance company.

Mucinous Carcinoma, Hypercellular Variant; Oncotype DX 27, Dx 7/8/2011, <1cm, Stage I, Grade 2, 0/3 nodes, ER+/PR-, HER2- Hormonal Therapy 7/19/2014 Arimidex (anastrozole)
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Dec 29, 2015 11:36AM Hopeful82014 wrote:

cp418 - Did you have any reaction at the site or other issues?

Dx IDC
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Dec 29, 2015 11:51AM cp418 wrote:

No - I had no issues and it was very easy for me to have an injection over IV. I think I was more achy post the Zometa infusions and didn't notice any discomfort after the Prolia shot. The nurse also reminded me important to take Vit D and Calcium supplements for either bone building medications.

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Dec 29, 2015 12:29PM Hopeful82014 wrote:

Thanks, cp418. I appreciate that info, as I'm going to start either zometa or prolia early next year.

I hear you on the Vit. D and calcium - I never cut myself any slack on those anymore.

Dx IDC
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Dec 29, 2015 07:55PM Jerseygirl927 wrote:

no reaction for me either. I do have a cracked tooth, so going to run that by the dentist to see if he has any thoughts on this!

Surgery 1/12/2015 Lymph node removal: Left, Sentinel; Mastectomy: Left, Right Dx 1/14/2015, ILC/IDC, Left, 1cm, Stage IA, Grade 1, 0/5 nodes, ER+/PR+, HER2+ Chemotherapy 2/25/2015 Carboplatin (Paraplatin), Taxol (paclitaxel) Hormonal Therapy 5/29/2015 Femara (letrozole) Dx IDC, ER+/PR+, HER2+ Dx ILC, 1cm, Stage IA, 0/1 nodes, ER+/PR+, HER2+
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Jan 21, 2016 07:51PM marianelizabeth wrote:

I start Prolia on Monday and am encouraged also with the latest results of a study that came out at the San Antonio Breast Cancer conference in December~~5 year study showing that Prolia also helps against breast cancer recurrence.

http://blog.aacr.org/sabcs-2015-denosumab-improves...


breastcancereh.blogspot.ca Surgery 9/7/2012 Lumpectomy: Right; Lymph node removal: Right, Sentinel Chemotherapy 10/15/2012 AC + T (Taxol) Surgery 3/5/2013 Lymph node removal: Right, Underarm/Axillary; Mastectomy: Right; Reconstruction (right): Tissue expander placement Hormonal Therapy 4/29/2013 Arimidex (anastrozole) Radiation Therapy 5/7/2013 External: Lymph nodes, Chest wall Surgery 12/6/2013 Reconstruction (left); Reconstruction (right) Surgery 12/12/2016 Reconstruction (right): Fat grafting, Silicone implant Surgery 6/26/2017 Reconstruction (right) Radiation Therapy 9/8/2017 Surgery 9/9/2019
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Jan 22, 2016 05:03AM Golden01 wrote:

Seeing my dentist today to be sure all is good and then will follow up with the MO to see what they've worked out with the insurance company for me starting Prolia.

Mucinous Carcinoma, Hypercellular Variant; Oncotype DX 27, Dx 7/8/2011, <1cm, Stage I, Grade 2, 0/3 nodes, ER+/PR-, HER2- Hormonal Therapy 7/19/2014 Arimidex (anastrozole)
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Jan 22, 2016 06:57AM SpecialK wrote:

I would recommend having a DEXA scan as close to the start of Prolia as possible so that you know your density starting point.  It may take up to two years (basically 4 injections, each six months apart) before you see improvement.  For me, at the fifth injection of Prolia I was back to normal density from just osteoporotic at several measurements.  I had been osteopenic for nine years prior to diagnosis with breast cancer due to total hyst/ooph at 45, but had remained stable until chemo and six months of Femara caused serious degradation.

BMX w/ TE 11/1/10, ALND 12/6/10. 15 additional surgeries. TCHx6 2/17-6/2/11. Herceptin until 1/19/12. Femara 8/1/11, Arimidex 6/20/12, back to Femara 6/18/13-present. Dx 9/27/2010, DCIS, Stage 0, Grade 3 Dx 9/27/2010, IDC, Right, 2cm, Stage IIB, Grade 3, 2/14 nodes, ER+/PR+, HER2+ (IHC)
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Jan 22, 2016 09:07AM Stephmoen wrote:

if approved I will start Prolia monday I am 30 on Aromasin after an oopherectomy to prevent reoccurrence I told my dr I wanted this drug that's why I'm getting it she also ordered a sexy scan I requested I don't know if I'm making the right choice but when I saw it reduces reoccurence rates I thought might as wel

Dx 3/17/2015, DCIS, Left, Stage 0, Grade 3 Dx 3/17/2015, IDC, Left, 1cm, Stage IB, Grade 3, ER+/PR+, HER2+ (IHC) Targeted Therapy 4/15/2015 Herceptin (trastuzumab) Chemotherapy 4/16/2015 Carboplatin (Paraplatin), Taxotere (docetaxel) Targeted Therapy Perjeta (pertuzumab)
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Jan 23, 2016 06:50AM Golden01 wrote:

Had my Dexa just before the holidays and the MO wanted a "no work needed" report from dentist before starting. Unfortunately, the place where I've always done my scans has changed a equipment and said we couldn't directly compare to previous reports but the numbers had decreased from previous ones. Still osteopenic not in the osteoporosis range but I want to stay on the AI (have been on it about a year and a half). Still have to see if the insurance agrees.

Mucinous Carcinoma, Hypercellular Variant; Oncotype DX 27, Dx 7/8/2011, <1cm, Stage I, Grade 2, 0/3 nodes, ER+/PR-, HER2- Hormonal Therapy 7/19/2014 Arimidex (anastrozole)
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Mar 3, 2016 06:06AM Golden01 wrote:

Dentist said I was good to go and the insurance company approved the Prolia. I'm off for my first injection today. Hope all goes well.

Mucinous Carcinoma, Hypercellular Variant; Oncotype DX 27, Dx 7/8/2011, <1cm, Stage I, Grade 2, 0/3 nodes, ER+/PR-, HER2- Hormonal Therapy 7/19/2014 Arimidex (anastrozole)
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Mar 11, 2016 07:32AM Mshea wrote:

Mine did the same, however his face when he saw my numbers dripped was horrifying. They stopped the Fosimax immediately as if I continue, they would turn to powder. Insurance didn't cover it the first time but after resubmitting the Prolia now they are all in.

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Mar 12, 2016 05:44AM Golden01 wrote:

Going to work harder on exercise to build my bones too. Hurt my foot and got away from walking but have my Fitbit on today!

Mucinous Carcinoma, Hypercellular Variant; Oncotype DX 27, Dx 7/8/2011, <1cm, Stage I, Grade 2, 0/3 nodes, ER+/PR-, HER2- Hormonal Therapy 7/19/2014 Arimidex (anastrozole)
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Mar 18, 2016 08:02PM Jerseygirl927 wrote:

golden the prolia didn't bother you did it? I am due for 2nd prolia in April, so far no issues, and trying yoga and prunes, calcium, and more for stronger bones too.

Surgery 1/12/2015 Lymph node removal: Left, Sentinel; Mastectomy: Left, Right Dx 1/14/2015, ILC/IDC, Left, 1cm, Stage IA, Grade 1, 0/5 nodes, ER+/PR+, HER2+ Chemotherapy 2/25/2015 Carboplatin (Paraplatin), Taxol (paclitaxel) Hormonal Therapy 5/29/2015 Femara (letrozole) Dx IDC, ER+/PR+, HER2+ Dx ILC, 1cm, Stage IA, 0/1 nodes, ER+/PR+, HER2+
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Mar 19, 2016 08:33AM Golden01 wrote:

No, I really didn't feel anything at all. This week, seemed to have a bit of a sore tooth which scared me but has gotten better so I think all is well. Thinking strong bones and wearing my Fitbit every day. They did have me wait a half an hour or so after the shot and rechecked my blood pressure before I headed home. My injection was given at the center's infusion center.

Mucinous Carcinoma, Hypercellular Variant; Oncotype DX 27, Dx 7/8/2011, <1cm, Stage I, Grade 2, 0/3 nodes, ER+/PR-, HER2- Hormonal Therapy 7/19/2014 Arimidex (anastrozole)
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Mar 22, 2016 07:32PM Jerseygirl927 wrote:

yes I get mine at the oncologists office. I was very worried in the beginning but now as you say " think strong bones". Nothing else.

Surgery 1/12/2015 Lymph node removal: Left, Sentinel; Mastectomy: Left, Right Dx 1/14/2015, ILC/IDC, Left, 1cm, Stage IA, Grade 1, 0/5 nodes, ER+/PR+, HER2+ Chemotherapy 2/25/2015 Carboplatin (Paraplatin), Taxol (paclitaxel) Hormonal Therapy 5/29/2015 Femara (letrozole) Dx IDC, ER+/PR+, HER2+ Dx ILC, 1cm, Stage IA, 0/1 nodes, ER+/PR+, HER2+
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Apr 11, 2016 11:45AM HomeMom wrote:

How many IU a day do you ladies take of VitD3 and Calcium? I take Fosomax once a week and 5,000 IU of Vit D plus 1,200 IU of Calcium. I had some bone loss at my first Dexa and it increased by the second. I heard you can over do the Vit D thing.

I am working out 3-4 days a week but I want to see one of the personal trainers there so I can do some weights. Not sure how I should go about it with the risk of LE

Dx 3/31/2014, IDC, 2cm, Stage IIB, Grade 1, 3/29 nodes, ER+/PR+, HER2- Surgery 4/14/2014 Lumpectomy: Left Surgery 5/5/2014 Lymph node removal: Left, Underarm/Axillary; Mastectomy: Left; Reconstruction (left): Tissue expander placement Chemotherapy 5/29/2014 AC Chemotherapy 7/24/2014 Taxol (paclitaxel) Radiation Therapy 10/15/2014 Hormonal Therapy 12/14/2014 Arimidex (anastrozole)
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Apr 12, 2016 04:24PM Golden01 wrote:

I took 4,000 IU a day until my blood levels of Vitamin D were raised to the 60+ level. Then I cut back to 2,000 IU a day. My internist was concerned about Vitamin D levels going too high. Make sure your doctor checks your blood levels of Vitamin D. That will determine the amount you need to take.

Mucinous Carcinoma, Hypercellular Variant; Oncotype DX 27, Dx 7/8/2011, <1cm, Stage I, Grade 2, 0/3 nodes, ER+/PR-, HER2- Hormonal Therapy 7/19/2014 Arimidex (anastrozole)

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