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Topic: Fosamax or Prolia?

Forum: Bone Health and Bone Loss —

Talk with others about bone density, osteopenia and osteoporosis, and ways to keep your bones strong

Posted on: Dec 30, 2015 10:07PM

Bad_At_Usernames wrote:

Not for me, but for my mom. She has been on Femara since Summer 2014 for Stage I, highly hormone positive cancer. A DEXA scan in Sept. showed a concerning loss in bone density and she was put on Fosamax, a pill once a week. Since starting it, she had bad flu-like symptoms the day or so after she took it. She stopped taking it maybe six weeks ago, on the advice of her PCP. I was wondering if Prolia might be a better option for her since it's only given every six months (so she only has to deal with the side effects twice a year as opposed to every month). Also, it has the benefit of helping prevent bone mets in post menopausal women. Any thoughts on Prolia

"...to survive this disease, you had to be an eternal optimist and very aggressive..." -Vince DeVita Dx 12/23/2013, IDC, 6cm+, Stage IIIC, Grade 3, ER+/PR+, HER2+ Chemotherapy 1/15/2014 AC + T (Taxol) Targeted Therapy 3/16/2014 Perjeta (pertuzumab) Targeted Therapy 3/16/2014 Herceptin (trastuzumab) Surgery 7/10/2014 Lymph node removal: Left, Underarm/Axillary; Mastectomy: Left Radiation Therapy 8/28/2014 Breast, Lymph nodes Targeted Therapy 9/22/2014 Kadcyla (T-DM1, ado-trastuzumab) Hormonal Therapy 11/17/2014 Zoladex (goserelin) Hormonal Therapy 1/31/2015 Femara (letrozole) Dx 1/7/2016, IDC, Stage IV, metastasized to brain Targeted Therapy 1/14/2016 Verzenio Radiation Therapy 7/26/2016 External: Brain Targeted Therapy 11/15/2016 Tykerb (lapatinib) Dx 3/23/2017, IDC, Stage IV, metastasized to liver Chemotherapy 3/28/2017 Xeloda (capecitabine) Chemotherapy 8/29/2017 Taxotere (docetaxel) Radiation Therapy 2/26/2018 External: Brain
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Dec 31, 2015 09:01AM cp418 wrote:

There are several topics posted here for Prolia. It is certainly another option for someone who cannot tolerate the oral medications.

http://www.breastcancer.org/research-news/prolia-l...


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Dec 31, 2015 11:10AM SpecialK wrote:

bad - I have been on Prolia for several years.  I was osteopenic prior to BC diagnosis due to an early hyst/ooph.  After chemo and six months of Femara I had demonstrated loss after remaining relatively stable for years.  I have no side effects from Prolia and is reversed my loss - I now have normal bone density.  Prolia is a different drug mechanism from Fosamax so the side effects may be different for your mom. Fosamax coats the bone, but Prolia slows the old bone removal mechanism, allowing the new bone to catch up.

BMX w/ TE 11/1/10, ALND 12/6/10. 15 additional surgeries. TCHx6 2/17-6/2/11. Herceptin until 1/19/12. Femara 8/1/11, Arimidex 6/20/12, back to Femara 6/18/13-present. Dx 9/27/2010, DCIS, Stage 0, Grade 3 Dx 9/27/2010, IDC, Right, 2cm, Stage IIB, Grade 3, 2/14 nodes, ER+/PR+, HER2+ (IHC)
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Dec 31, 2015 10:58PM Bad_At_Usernames wrote:

thanks K! Interesting about how the drugs work differently...I sent her an article from SABCS and she's going to talk to her onc about it next month. She's pretty low risk for recurrence but 100%ER+ so staying on AIs is critical.

"...to survive this disease, you had to be an eternal optimist and very aggressive..." -Vince DeVita Dx 12/23/2013, IDC, 6cm+, Stage IIIC, Grade 3, ER+/PR+, HER2+ Chemotherapy 1/15/2014 AC + T (Taxol) Targeted Therapy 3/16/2014 Perjeta (pertuzumab) Targeted Therapy 3/16/2014 Herceptin (trastuzumab) Surgery 7/10/2014 Lymph node removal: Left, Underarm/Axillary; Mastectomy: Left Radiation Therapy 8/28/2014 Breast, Lymph nodes Targeted Therapy 9/22/2014 Kadcyla (T-DM1, ado-trastuzumab) Hormonal Therapy 11/17/2014 Zoladex (goserelin) Hormonal Therapy 1/31/2015 Femara (letrozole) Dx 1/7/2016, IDC, Stage IV, metastasized to brain Targeted Therapy 1/14/2016 Verzenio Radiation Therapy 7/26/2016 External: Brain Targeted Therapy 11/15/2016 Tykerb (lapatinib) Dx 3/23/2017, IDC, Stage IV, metastasized to liver Chemotherapy 3/28/2017 Xeloda (capecitabine) Chemotherapy 8/29/2017 Taxotere (docetaxel) Radiation Therapy 2/26/2018 External: Brain
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Jan 1, 2016 12:53AM LisaAlissa wrote:

Just to chime in, with a similar diagnosis, my Mom's MO put her on both Femara and Prolix from the get-go, as well as 1000 IUs of D3. Mom has never reported any adverse effects (other than discomfort during the injection itself...which is less if it's administered very, very slowly).

Best wishes to your mom (and happy new year!),

LisaAlissa

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May 4, 2016 10:29PM Bad_At_Usernames wrote:

I never updated due to my own brain mets situation, but mom indeed get on Prolia without issue. Her symptoms overall have gotten better, although some aches and pains remain (likely due to Femara and aging). And the prevention of bone mets in post-menopausal women aspect is a big plus. It's bad enough we have a family oncoparty going on, I really don't want her to join me in Club Mets..

"...to survive this disease, you had to be an eternal optimist and very aggressive..." -Vince DeVita Dx 12/23/2013, IDC, 6cm+, Stage IIIC, Grade 3, ER+/PR+, HER2+ Chemotherapy 1/15/2014 AC + T (Taxol) Targeted Therapy 3/16/2014 Perjeta (pertuzumab) Targeted Therapy 3/16/2014 Herceptin (trastuzumab) Surgery 7/10/2014 Lymph node removal: Left, Underarm/Axillary; Mastectomy: Left Radiation Therapy 8/28/2014 Breast, Lymph nodes Targeted Therapy 9/22/2014 Kadcyla (T-DM1, ado-trastuzumab) Hormonal Therapy 11/17/2014 Zoladex (goserelin) Hormonal Therapy 1/31/2015 Femara (letrozole) Dx 1/7/2016, IDC, Stage IV, metastasized to brain Targeted Therapy 1/14/2016 Verzenio Radiation Therapy 7/26/2016 External: Brain Targeted Therapy 11/15/2016 Tykerb (lapatinib) Dx 3/23/2017, IDC, Stage IV, metastasized to liver Chemotherapy 3/28/2017 Xeloda (capecitabine) Chemotherapy 8/29/2017 Taxotere (docetaxel) Radiation Therapy 2/26/2018 External: Brain

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