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All TopicsForum: Bone Health and Bone Loss → Topic: Study Prompts Revision in Bone-loss-prevention Guidelines

Topic: Study Prompts Revision in Bone-loss-prevention Guidelines

Forum: Bone Health and Bone Loss — Talk with others about bone density, osteopenia and osteoporosis, and ways to keep your bones strong

Posted on: Apr 28, 2017 10:35AM

cp418 wrote:

https://breastcancer-news.com/2017/04/27/study-on-...


Breast Cancer and Fractures Study Prompts Revision in Bone-loss-prevention Guidelines Log in to post a reply

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Apr 28, 2017 03:57PM wallycat wrote:

More treatment, more stuff goes wrong. Hate it.

The jaw issues weren't mentioned in any of it...and many post meno gals will have gum issues because of lack of estrogen.

Dx 4/07 1 month before turning 50; ILC 1.8cm, ER+/PR+, HER2 neg., Stage 1, Grade 2, 0/5 nodes. Onco score 20, Bilateral Mast., tamoxifen 3-1/2 years, arimidex-completed 4/20/2012
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May 7, 2017 06:54AM - edited May 7, 2017 07:02AM by Heidihill

There is a mistake in the linked article with reference to denosumab and zoledronate as it differs from the original press release and study. Zoledronate is for when disease recurrence is a priority, denosumab for fracture risks.

https://eurekalert.org/pub_releases/2017-04/iof-ngf042517.php

I thought the guideline below was interesting from a mets viewpoint. As in: if they recommend this for all postmeno early stagers with ER+ , then every ER+ postmeno metser on AIs might benefit from it as well, even without bone mets. At least in theory.

Because of the decreased incidence of bone recurrence and breast cancer specific mortality associated with bisphosphonate use, adjuvant bisphosphonates are recommended for all postmenopausal women at significant risk of disease recurrence.

For me 5 years of bisphosphonates was well worth it. I had a blood test for bone turnover each time I needed an invasive dental procedure. I gained bone density with the combination of bisphosphonates and lifting weights.

Dx 8/2007, IDC, Left, 2cm, Stage IV, metastasized to bone, Grade 2, 2/19 nodes, mets, ER+/PR+, HER2- (FISH) Hormonal Therapy 3/25/2015 Tamoxifen pills (Nolvadex, Apo-Tamox, Tamofen, Tamone)
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May 7, 2017 09:30PM Falconer wrote:

Thanks, Heidihill.
Strong is the new strong. Dx at 45. Onco 16. Monthly Lupron shots. Dx 7/2016, IDC, Left, 1cm, Stage IB, Grade 2, 0/3 nodes, ER+/PR+, HER2- Dx 7/2016, DCIS, Left, 5cm, Stage 0, Grade 3, 0/3 nodes, ER+/PR+, HER2- Surgery 5/30/2017 Reconstruction (left): DIEP flap Surgery Lymph node removal: Sentinel; Mastectomy: Left Radiation Therapy Whole-breast: Breast, Lymph nodes, Chest wall Hormonal Therapy Aromasin (exemestane), Femara (letrozole)
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May 8, 2017 02:51AM - edited May 8, 2017 02:51AM by testus

This Post was deleted by testus.
Be Strong
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May 15, 2017 10:02AM Eian01 wrote:

The more it involves processes the higher risks will be fractures

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May 17, 2017 09:25AM peggy_j wrote:

Heidihill, can you tell me more about that blood test that checked bone turnover. I've never heard of this. What are they checking? We've been monitoring my bone density every two years but I'm wondering if I should be getting this blood test to see what is going on. Thanks

Dx 2/2011, IDC, <1cm, Stage IA, Grade 1, 0/3 nodes, ER+/PR+, HER2-
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May 17, 2017 11:32AM Heidihill wrote:

From Wikipedia:

In the early 2000s, a link between bisphosphonate use and impaired bone physiology was noted.[3][4] The strong inhibition of osteoclast function precipitated by bisphosphonate therapy can lead to inhibition of normal bone turnover, leading to impaired wound healing following trauma (such as dental surgery) or even spontaneous non-healing bone exposure. Because bisphosphonates are preferentially deposited in bone with high turnover rates, it is possible that the levels of bisphosphonate within the jaw bones are selectively elevated With the advent of implant dentistry, more dental patients are undergoing therapies in the oral cavity that involve bone healing, such as surgical implant placement and bone grafting procedures. In order to evaluate the risk of osteonecrosis for a patient taking bisphosphonates, use of the CTX biomarker was introduced in 2000 by Rosen.

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I don't know if it is still being used as it has been some time since I was getting Zometa infusions.

Dx 8/2007, IDC, Left, 2cm, Stage IV, metastasized to bone, Grade 2, 2/19 nodes, mets, ER+/PR+, HER2- (FISH) Hormonal Therapy 3/25/2015 Tamoxifen pills (Nolvadex, Apo-Tamox, Tamofen, Tamone)
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May 17, 2017 04:58PM - edited May 17, 2017 04:58PM by peggy_j

Great, thanks for posing. I emailed my endocrinologist and he said that he wants to hold off on ordering any tests until we meet and review my DEXA images. BTW, he said bone marker tests can be $$ and some insurance plans don't cover the cost. Was that your experience?

Dx 2/2011, IDC, <1cm, Stage IA, Grade 1, 0/3 nodes, ER+/PR+, HER2-
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May 18, 2017 05:46PM Heidihill wrote:

insurance covered it for me. But I am not in the US where medical costs tend to be higher.

Dx 8/2007, IDC, Left, 2cm, Stage IV, metastasized to bone, Grade 2, 2/19 nodes, mets, ER+/PR+, HER2- (FISH) Hormonal Therapy 3/25/2015 Tamoxifen pills (Nolvadex, Apo-Tamox, Tamofen, Tamone)

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