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Topic: prunes and this and not happy....

Forum: Bone Health and Bone Loss —

Talk with others about bone density, osteopenia and osteoporosis, and ways to keep your bones strong

Posted on: Apr 29, 2017 10:11AM

wallycat wrote:

If anyone with a more detailed science background reads this and can give their 2 cents on prunes/bones/cancer, I'd love to hear it:

Dx 4/07 1 month before turning 50; ILC 1.8cm, ER+/PR+, HER2 neg., Stage 1, Grade 2, 0/5 nodes. Onco score 20, Bilateral Mast., tamoxifen 3-1/2 years, arimidex-completed 4/20/2012
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May 4, 2017 06:17PM peggy_j wrote:

I don't have time to read and research this but my MO usually asks:

--how many people were in the study

--has it been duplicated


Dx 2/2011, IDC, <1cm, Stage IA, Grade 1, 0/3 nodes, ER+/PR+, HER2-
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May 5, 2017 08:59AM Icantri wrote:

I am a regular subscriber to the author's newsletters and very much value his expertise. (I am not a medical professional.)

I personally am not going to avoid prunes yet though because, as he himself says in the article:

"Trying to judge the value or danger of a food by any single chemical action is asking for confusion. At this point we must be clear that prunes have not been shown to cause, speed up or in any way change cancer. All we know is that they increase production of IGF-I in post-menopausal women. In some situations this might be seen as a good thing, in other situations not so. "

Just my two cents. The benefits of prunes in conjunction with a healthy diet and exercise may counteract the effects of the increase in IGF-I, or at least outweigh the risks for most of us. I hope. :)
48 years old at diagnosis Dx 10/18/2016, IDC, Right, 1cm, Stage IA, Grade 1, 0/4 nodes, ER+/PR+, HER2- Surgery 11/16/2016 Mastectomy: Right Hormonal Therapy 12/14/2016 Tamoxifen pills (Nolvadex, Apo-Tamox, Tamofen, Tamone)
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Aug 18, 2017 11:25AM - edited Aug 18, 2017 11:30AM by peggy_j

Wallycat, I noticed the source listed studies from 2000 and 2002. I haven't had time to read all that, but yesterday I went onto PubMed and there appear to be many studies that suggest prunes are healthy and can reduce bone loss. This is a PDF of the meta-analysis published this year:

Dried Plums, Prunes and Bone Health: A Comprehensive Review

(the conclusions are listed on p. 17 and 18)

Conclusions Dried plums are an easy means to help individuals meet their daily recommendations for fruit intake. The beneficial effects of dried plums on bone health may be in part due to the unique variety of phenolics and nutrients present in the fruit. Animal and cell studies suggest that dried plums and/or their extracts enhance bone formation and inhibit bone resorption through their actions on cell signaling pathways that influence osteoblast and osteoclast differentiation; however, results on specific markers are not consistent across and between studies. Animal studies are somewhat consistent with small clinical interventions that show dried plums may exert beneficial effects on total body and site-specific BMD. Long-term prospective cohort studies using fractures and BMD as primary endpoints are needed to confirm the effects of smaller clinical, animal and mechanistic studies. No adverse effects were noted among any of the studies included in this comprehensive review. While the data are not completely Nutrients 2017, 9, 401 18 of 21 consistent, this review suggests that postmenopausal women may safely consume dried plums as part of their fruit intake recommendations given their potential to have protective effects on bone loss.

BTW, has Jacob Schor published any of his findings in a peer-reviewed journal? That purple background makes me question how legit his findings are.

Dx 2/2011, IDC, <1cm, Stage IA, Grade 1, 0/3 nodes, ER+/PR+, HER2-
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Aug 18, 2017 01:12PM MTwoman wrote:

I'm with peggy. His web page does not scream "peer reviewed journal".

Dx 12/10/2002, DCIS, Right, 1cm, Stage 0, Grade 2, 0/3 nodes, ER-/PR-, HER2- Surgery 12/19/2002 Lumpectomy: Right; Lymph node removal: Sentinel Surgery 12/23/2003 Reconstruction (right): Nipple reconstruction Surgery Reconstruction (right): Saline implant Surgery Reconstruction (right): Tissue expander placement Surgery Mastectomy: Right

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