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Apr 5, 2012 04:09AM
Just as well they listened to me at least once.
The first Cancer conference I attended about 16 years ago was a joint Lorne (Vic Aust) AACR (American Association of Cancer Research) conference. A lecture on the second day was about bowel cancer in which the number one tumour repressor p53 was mutated, presumably the reason for the tumour, and it secreted a prostaglandin PGF2. Now I knew that PGF2 constricted or narrowed blood vessels supplying the gastrointestinal tract and suddenly I had a different spin on the sequence of events. At question time I suggested that hypoxia or oxygen starvation was the cause of the bowel cancer, not the mutations in the p53 tumour repressor. I suggested that the mutations in the p53 were a RESULT of the hypoxia. As I said this tumour secreted a prostaglandin PGF2 which is a vasoconstrictor. Adrenalin activates PGF2 in the gastro-intestinal tract in response to 'fight or flight', stress in other words. My theory went like this. Stress>adrenalin>PGF2>vasoconstriction>HYP OXIA>p53 mutation>CANCER.
At the end of the symposium a chap approached me and suggested that this was a very interesting idea as he was working on the same cells. It turned out that he was the AACR convenor. I saw him later and explained to him what is called the RAS pathway by which adrenalin works. He said, "You must be a very good biochemist" I was nonplussed by this as I didn't thing my suggestion was anything extraordinary and I replied that "I'm not a biochemist, I'm an electronic technician, this is just a hobby for me. He looked dumbfounded as if I was taking the Mickey out of him and didn't say anything, then took off. I didn't run into him again for the rest of the Conference.
The following year when I went to pay the Conference secretary for everything, registration, all meals and accommodation she whispered as she handed me my bag, "Don't worry Noddy, it all been taken care off" ($750}. I was gobsmacked as there was no explanation as to why. The same thing happened for the following two years the gradually tapered off. I know now. You see my answer that day involved endocrinology, biochemistry, haematology, oncology, molecular biology etc. all of which I had studied BECAUSE I DIDN'T KNOW THAT I WASN'T SUPPOSED TO. All of the delegates were molecular biologist looking for GENES to blame, then design the appropriate drug. It is pure commerce and that blinds totally. These conferences would not be possible without large scale funding from lab suppliers, pharmaceutical companies etc. This, plus Dawkinist dogma, makes it IMPOSSIBLE to understand cancer, let alone find a cure. How could the delegates POSSIBLY admit that an amateur scientist had worked something out that the entire global community of cancer researchers couldn't.
At the last cancer conference that I attended about 5 years ago there were two lectures on the discovery of the HIF (hypoxia induction factor) genes that switched on proliferation of cells and angiogenesis (growth of blood vessels to allow cell growth), CANCER in other words and based on my suggestion all those years before, yet I got no recognition whatsoever. Hypoxia is probably the most important tumour inducer of all.
THE WARBURG EFFECT.
The Warburg effect refers to a characteristic in which cancer cells use less and less oxygen as they become more malignant. Cancer researchers use the term but it has fallen into misuse as cancer is seem more and more as simply a stuff up. I use a LOT as it is pivotal to my theories on cancer. The other night I decided to check the history of what Warburg did to arrive at his conclusion. I ALMOST FELL OFF THE CHAIR AT WHAT I READ. Fifty years ago Otto Warburg discovered that when normal cells in a Petri dish were deprived of oxygen they transformed into cancer cells. That's it, nothing else, just deprived of oxygen. So this has been known for FIFTY years yet all of those 500 delegates at my first Cancer conference, half from the biggest cancer research organisation in the world, didn't know about. If I had known that day I would NOT have suggested it and the genes might not have been found. But then it's not my job to know. HYPOXIA can be caused by a number of things, primarily vasoconstriction. Vasoconstriction to the gastro intestinal tract, resulting from persistent stress, means malabsorption of nutrients such as IRON needed for red blood cells to transport OXYGEN. Now add gunked up blood vessels due to glucose and cholesterol forming plaques and thus even worse hypoxia.
Blood vessels have carbon dioxide detector nodes along them, so that if CO2 builds up in the bloodstream, meaning reduced oxygen, then the heart increases its output, the result being higher blood pressure. Now gunked up blood vessels inhibit the flow of blood through them so the heart has to increase it's output to compensate, meaning higher blood pressure and risk of stroke. So you take blood pressure controls e.g. beta blockers and you lower your blood pressure but increase your RISK OF CANCER by definition, the Warburg effect.