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Aug 9, 2011 07:44PM
Aug 9, 2011 07:47PM
Using a touch screen so cant cut and paste, so have copied the following ..it includes some paragraphs from a review on oxidative stress. I am open to discussion of this review:
Hypoxia and oxidative stress in breast cancer
Oxidative stress: its effects on the growth, metastatic potential and response to therapy of breast cancer
Nicholas S Brown and Roy Bicknell Molecular Angiogenesis Laboratory, imperial Cancer Research Fund, Weaterall Institut of Molecular Medicine, John Radcliffe Hospital, University of Oxford, Oxford, UK
...An antipoptotic response to chronic oxidative stress may have severe implications for anticancer therapy. As outlined above, radiotherapy, photodynamic therapy and many chemotherapies generate oxygen radicals. Their antitumour activity is to a degree dependent on the induction of tumour cell apoptosis in response to oxidative stress and oxygen radical induced DNA damage. Persistent oxidative stress within carcinoma cells may therefore cause resistance to therapy. Oxygen radicals might also increase drug resistance by increasing carcinoma cell expression of P-glycoprotein, the multidrug-resistance efflux pump.
....oxidative stress may aid the seeding of metastatic tumour cells
....Oxidative stress within breast tumours may also facilitate invasion and metastasis by activating MMPs and inhibiting antiproteases.
...In conclusion: Carcinoma cells synthesize ROS at an elevated rate in vitro, and many tumours in vivo appear to be under persistent oxidative stress. The present review outlines potential causes of carcinoma cell oxidative stress...and summarizes mechanisms by which oxygen radicals may affect the outcome of breast cancer. Future experiments will reveal the extent to which oxidative stress influences the prognosis of breast carcinoma. If oxygen radicals do lead to a poorer prognosis, then antioxidants may be of therapeutic value. This is an exciting possibility, because antioxidants are drugs of low toxicity. Evidence from other tumour types suggests that antioxidants may indeed be of use against breast cancer...
This review can be read in full by typing the heading into google.
It is the opportunity to build what one loves into something permanent that makes this very difficult game worthwhile. mets skull, rib, hip, spine.
8/2010, IDC, 1cm, Stage IV, mets, ER+/PR+, HER2-