Aug 7, 2012 10:19PM - edited Aug 7, 2012 10:51PM by Ruby-
Hi Natkat, thanks for this thread - hopefully, your wishes will be respected
I'm two years post-treatment, took Tamox for 18 months, decided to discontinue because of severe SEs and possible endometrial cancer (had two scary AND extremely painful biopsies while on Tamox) and have been taking a DIM/I3C/Calcium D Glucarate/rosemary/turmeric combo for approx 6 months. Am planning on adding chrysin, grape seed extract and olive leaf to my protocol. Am also taking green tea extract.
I have to admit that pain and tightness are still bothering me but see it as a sign that the above is definitely working. I no longer have to worry about secondary cancers though and my cognitive function has definitely improved (another nasty SE from Tamox)
I have to emphasize that soy or any of its derivatives is NOT part of my arsenal. Hopefully, this will not become yet another argument for the bean, as many other threads have done just that. I have read enough cons about it to keep it at arm's length. Prior to my dx, I was taking genistein for premenopausal symptoms and I am certain it actually fueled my BC.
I have tons of research I would like to share:
"Natural Aromatase Inhibitors
Nature has provided an abundance of aromatase inhibitors
You don't have to take drugs to inhibit aromatase. Nature has provided plants that will get the job done without harmful side effects. Research showed that chrysin worked as well to inhibit the aromatase enzyme as a drug designed for that purpose. Chrysin is normally taken as a supplement along with piperine which greatly enhances its bioavailability.
For those who would rather get their aromatase inhibiting flavonoids from whole foods, there are several good tasting choices. Beneficial compounds gotten from food have the added benefits of the perfect synergy found in a whole food as well as the other nutrients and compounds it contains.
Quercetin, naringenin, resveratrol, apigenin, genistein, and oleuropein are all powerful flavonoids from whole foods that inhibit aromatase while at the same time offering a treasure chest of other health benefits. When these foods are organically grown, they are higher in these flavonoids than produce grown conventionally.
Quercetin is the main reason an apple a day keeps the doctor away. It is a major antioxidant with important anti-aging benefits. It fights inflammation and reduces the cellular damage inflammation causes. By fighting inflammation, it also helps decrease swelling and pain, and keeps the circulatory system healthy. Quercetin helps prevent fatigue by helping to decrease damage from heavy exercise, and increase endurance. It is an anti-viral, and an immune system supporter and liver protector. Research has suggested that quercetin has other anti-cancer benefits aside from inhibiting aromatase in breasts and prostates. Cabbage, onions and garlic are other good sources of this powerful flavonoid.
Apigenin is a non-mutigenic flavonoid that has significant chemoprotective action against UV radiation. Research has shown apigenin reduces oxidative damage of DNA, inhibits the growth and induces differentiation in human leukemia cells, inhibits cancer cell transduction, and induces appropriate cell death. Like quercetin, apigenin acts as an anti-inflammatory and as an antispasmodic. Apigenin is found in good supply in celery, parsley, artichokes, basil, and chamomile.
Naringenin, is an antioxidant, free radical scavenger, anti-inflammatory, and immune system modulator. It has been shown to promote proper metabolism of carbohydrates. It was shown to reduce hepatitis C virus production by infected liver cells in cell culture and to inhibit the secretion of very low density lipoprotein by cells. As a cancer fighter, it reduces oxidative damage to DNA. Naringenin is found in all citrus and may be the reason that diets high in citrus are negatively correlated with heart disease. However, naringenin should not be obtained from grapefruit or grapefruit juice, which has an inhibitory effect on the human cytochrome P450 isofrom, another enzyme in the same complex as the aromatase enzyme. This enzyme is involved in breaking down and metabolizing sex hormones and preventing their excess accumulation in the body, so inhibiting it is not a good idea.
Resveratrol is a flavonoid gaining wide respect for its multitude of health benefits. Several recent research studies have revealed that resveratrol is highly effective against breast cancer by inhibiting ER positive and negative cell proliferation, cell cycle progression, and primary breast tumor growth. Resveratrol is protective of the liver even against alcohol. It also keeps the central nervous system strong by protecting neurons from oxidative stress. Resveratrol is found to some degree in the skin and seeds of red grapes. Muscadine grapes have the largest content and are often used to make red wine. Although supplements of resveratrol are popular and widely available, getting resveratrol from red wine allows you to get the entire grape polyphenol group of nutrients, a group that has been shown to work much better synergistically. Breast tumor growth and metastasis to bone and liver were shown to be better inhibited by the complete grape polyphenol complex.
Oleuropein gives olive oil its distinctive flavor and is found in abundance in the leaves of the olive tree. It is one of the reasons olive leaf is such a powerful tool for wellness. Oleuropein helps the body fight off viruses, bacteria, and fungi. It is contained in every part of the olive tree and is the basis of its defense from insects. Oleuropein has been shown to boost the immune defense of people too, as well as fostering a healthy balance between friendly bacteria in the intestinal tract. In animal research, oleuropein was shown to enhance nitric oxide production. It is also a potent antioxidant and anti-inflammatory.
All these foods are prominent features of the Mediterranean diet
Fresh fruits, vegetables, olive oil and red wine are components of the Mediterranean diet, the one and only diet that has consistently correlated with lower death rates from all causes. Flavonoids from each of these foods inhibit aromatase activity to reduce incidence of breast cancer. And when you choose a diet that features these foods on a regular basis, what you are really getting is the best all around prevention plan on earth.
Natural products targeting aromatase gene promoters
With the clinical success of several synthetic AIs in the
treatment of postmenopausal ER-positive breast cancer,
researchers have also been focused onto the potential of
natural products as AIs . These compounds (natural
products) are mostly obtained from terrestrial and marine
organisms and are still in the forefront of drug discovery.
Re : Apigenin
Nutr Cancer. 2001;39(1):13947. Apigenin acts on the tumor cell invasion process and regulates protease production. Lindenmeyer F, Li H, Menashi S, Soria C, Lu H. Institut National de la Sante et de la Recherche Medicale, U553, Bat. INSERM, Institut d'Hematologie, Hopital SaintLouis, Universite Paris 7, 75475 Paris, France.
35 Research abstracts at : http://www.lef.org/abstracts/codex/apigenin_abstracts.htm?source=search&key=natural%20aromatase%20inhibitors
On the role of lignans as estrogen blockers
Meta-analyses of lignans and enterolignans in relation to breast cancer risk.
Buck K, Zaineddin AK, Vrieling A, Linseisen J, Chang-Claude J.
Epidemiologic studies that examined whether lignans, the most important class of phytoestrogens in the Western diet, protect against breast cancer have yielded inconsistent results. OBJECTIVE: In this study, we conducted meta-analyses on the association between lignans and breast cancer risk. DESIGN: We performed a systematic MEDLINE search to identify epidemiologic studies published between 1997 and August 2009. We calculated pooled risk estimates (REs) for total lignan exposure, dietary lignan intake, enterolignan exposure, and blood or urine concentrations of enterolactone and according to menopausal and estrogen receptor (ER) status of tumors. RESULTS: We included 21 studies (11 prospective cohort studies and 10 case-control studies) in the meta-analyses. Lignan exposure was not associated with an overall breast cancer risk (RE: 0.92; 95% CI: 0.81, 1.02; P for heterogeneity = 0.004).
However, in postmenopausal women, high lignan intake was associated with a significant reduced risk of breast cancer (13 studies; RE: 0.86; 95% CI: 0.78, 0.94; P for heterogeneity = 0.32). Breast cancer risk was also inversely associated with enterolignan exposure (4 studies; RE: 0.84; 95% CI: 0.71, 0.97) but not with blood or urine enterolactone concentrations. The associations were not significantly different between ER-status subgroups (6 studies).
CONCLUSIONS: High lignan exposure may be associated with a reduced breast cancer risk in postmenopausal women. Additional work is warranted to clarify the association between lignan exposure and breast cancer risk.
Estrogen Inhibiting Foods
Fruits (except apples, cherries, dates, pomegranates)
Flax seed's other primary ingredient we are emphasizing in this report is a group of phytoestrogenic compounds known as lignans. Flax seed contains 100 times more lignans than the next closest food. Lignans get broken down by intestinal bacteria into enterodiol and enterolactone, two mammalian lignans.
Lignans contain powerful anti-cancer fighting agents and are especially effective against breast, colon, uterus and prostate cancers by controlling the sex hormones in our systems. As one example, lignans seem to flush excess estrogen from the body. Research has just begun on this fascinating subject. Lignans also seem to have anti-fungal, antibacterial and anti-viral properties. Flax seed oil contains practically no lignans - you must eat the flax seed, first ground into a meal. Flax oil also is missing many of the nutrients needed to digest it. But these nutrients are located in the seed. Both from a health and economic standpoint, we suggest eating whole flax seed you grind yourself rather than the high priced flax seed oil.
Flax seed has been proven to markedly reduce cholesterol levels as effectively as oat bran and fruit pectin. This is probably due to it's unusually high levels of soluble and insoluble fiber. Flax's high quality fiber teamed with LNA and the rich lignans work together to build healthy blood lipid patterns.
"Biological Effects of Dietary Flaxseed in Patients with Breast Cancer." Abstract from the San Antonio Breast Cancer Symposium - December 2000, Thompson LU, Li T, Chen J, Goss PE Nutritional Sciences, University of Toronto, Toronto, ON, Canada; Medical Oncology, Princess Margaret Hospital, Toronto, ON, Canada