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Aug 18, 2012 01:47PM
Thank you for all the wonderful posts. I made a summary document so the info is organized. Please feel free to cut & paste into your own notes for easy reference. This post is LONG. read it all to get the full info.
Thank you to Ruby, my sister Mare (who isn't on this forum), and everyone else who posted useful info which is included in the below document:
Foods generally beneficial for curing ER+/PR+ cancers:
#1 choice: foods of the Brassica family including cruciferous veggies: broccoli, cauliflower, brussel sprouts, cabbage, kale, and mustard seed. **see below chart**
Avocado (mehtionine for estrogen metabolism)
Berries (especially blue berries)
Broccoli, kale, cabbage, radishes, cauliflower, watercress, etc.
Fresh Fruits (beneficial for flavenoids although not indicated on the chart)
**Flax Seeds (contra-indicated for some people)
Grapes (especially purple grapes and eat the seeds if you can, also red wine in LIMITED dose)
Onion & Garlic
White rice, tapioca
Natural Aromatase Inhibitors:
Nature has provided an abundance of aromatase inhibitors. You don't have to take drugs to inhibit aromatase. Nature has provided plants that will get the job done without harmful side effects. Research showed that chrysin worked as well to inhibit the aromatase enzyme as a drug designed for that purpose. Chrysin is normally taken as a supplement along with piperine which greatly enhances its bioavailability.
Beneficial compounds gotten from food have the added benefits of the perfect synergy found in a whole food as well as the other nutrients and compounds it contains.
Quercetin, naringenin, resveratrol, apigenin, genistein, and oleuropein are all powerful flavonoids from whole foods that inhibit aromatase and offer other health benefits as well. Organically grown foods contain the highest levels of these flavonoids.
Quercetin is the main reason an apple a day keeps the doctor away. It is a major antioxidant with important anti-aging benefits. It fights inflammation and reduces the cellular damage inflammation causes. By fighting inflammation, it also helps decrease swelling and pain, and keeps the circulatory system healthy. Quercetin helps prevent fatigue by helping to decrease damage from heavy exercise, and increase endurance. It is an anti-viral, and an immune system supporter and liver protector. Research has suggested that quercetin has other anti-cancer benefits aside from inhibiting aromatase in breasts and prostates. Cabbage, onions and garlic are other good sources of this powerful flavonoid.
Apigenin is a non-mutigenic flavonoid that has significant chemoprotective action against UV radiation. Research has shown apigenin reduces oxidative damage of DNA, inhibits the growth and induces differentiation in human leukemia cells, inhibits cancer cell transduction, and induces appropriate cell death. Like quercetin, apigenin acts as an anti-inflammatory and as an antispasmodic. Apigenin is found in good supply in celery, parsley, artichokes, basil, and chamomile.
Naringenin, is an antioxidant, free radical scavenger, anti-inflammatory, and immune system modulator. It has been shown to promote proper metabolism of carbohydrates. It was shown to reduce hepatitis C virus production by infected liver cells in cell culture and to inhibit the secretion of very low density lipoprotein by cells. As a cancer fighter, it reduces oxidative damage to DNA. Naringenin is found in all citrus and may be the reason that diets high in citrus are negatively correlated with heart disease. However, naringenin should not be obtained from grapefruit or grapefruit juice, which has an inhibitory effect on the human cytochrome P450 isofrom, another enzyme in the same complex as the aromatase enzyme. This enzyme is involved in breaking down and metabolizing sex hormones and preventing their excess accumulation in the body, so inhibiting it is not a good idea.
Resveratrol is a flavonoid gaining wide respect for its multitude of health benefits. Several recent research studies have revealed that resveratrol is highly effective against breast cancer by inhibiting ER positive and negative cell proliferation, cell cycle progression, and primary breast tumor growth. Resveratrol is protective of the liver even against alcohol. It also keeps the central nervous system strong by protecting neurons from oxidative stress. Resveratrol is found to some degree in the skin and seeds of red grapes. Muscadine grapes have the largest content and are often used to make red wine. Although supplements of resveratrol are popular and widely available, getting resveratrol from red wine allows you to get the entire grape polyphenol group of nutrients, a group that has been shown to work much better synergistically. Breast tumor growth and metastasis to bone and liver were shown to be better inhibited by the complete grape polyphenol complex.
Oleuropein gives olive oil its distinctive flavor and is found in abundance in the leaves of the olive tree. It is one of the reasons olive leaf is such a powerful tool for wellness. Oleuropein helps the body fight off viruses, bacteria, and fungi. It is contained in every part of the olive tree and is the basis of its defense from insects. Oleuropein has been shown to boost the immune defense of people too, as well as fostering a healthy balance between friendly bacteria in the intestinal tract. In animal research, oleuropein was shown to enhance nitric oxide production. It is also a potent antioxidant and anti-inflammatory.
Packaged Preparations (not endorsing - just listing for convenience)
Suplements & Herbs most of us agreed on:
DIM (bio available)
Supplements specific to Estrogen Metabolism
(not estrogen blockers - estrogen metabolizers working on Methylation pathway)
L-Methionine (amino acid) estrogen conversion
Methylcobalamin B12 (vitamin) estrogen conversion
MSM - estrogen conversion
Calcium D-Gluconate (assists removal of estrogen via bowels)
Estrogen is metabolized by the liver and eliminated through the bowels. Strengthen liver function. Detoxify both liver and bowels. Over-the-counter products I recommend:
Yogi Tea "Detox" and Michael Tierra Tri-Cleanse.
These are not medicinal but can be used by anyone - no professional guidance necessary.
If you are working with a Naturopath, TCM, or Ayurvedic practioner, they will likely have medicinal liver-strengthening or detoxifying protocols included in your treatment.
D-glucarate is found in apples, oranges, broccoli, spinach, and Brussels sprouts. To metabolize estrogens, your liver joins them to glucoronic acid so they can be eliminated through the bowel. In some cases, a gut bacteria called beta-glucuronidase breaks this bond and allows the estrogen to be re-circulated in the body. D-glucarate inhibits an enzyme produced by the beta-glucuronidase so improves your chances to eliminate estrogens through the bowel successfully.
Juice greens and herbs known to contain the phytochemical indole-3-carbinol to improve detox of environmental estrogen. Especially watercress http://www.ncbi.nlm.nih.gov/pubmed/20546646
Iodine Protocols may be beneficial for estrogen related cancers http://www.breastcancerchoices.org/iodine.html
- Lugols' solution & DMSO topically
- Iodoral protocol: Iodoral 12.5 - 50 mg, vitamin C (Ascorbyl palmitate, ascorbic acid, ascorbate) 3000 mg, magnesium (citrate or oxide) 300-600 mg, Selenium or L-selenomethionine 200 mg, B3 Niacin (inositol hexanicotinate) 500mg, B2 Riboflavin 100mg
Possible - Worth researching:
Ginseng (American vs. Asian)
Green tea extract / EGCG - general, still researching role in estrogen related cancers
ID3 - similar to DIM but contra-indicated in some cases?
CoQ10 - general, still researching role in estrogen related cancers
Omega 3 & fish oil fatty acids - general, still researching role in estrogen related cancers
6/2012, ILC, 4cm, Stage IIA, Grade 2, 0/3 nodes, ER+/PR+