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Oct 10, 2013 12:26PM
Deanna, thanks for posting the links. I just did a google search for "grape seed breast cancer pub med" and there are many studies that suggest grape seed extract improves outcomes for ER+ BC patients. That's terrific. Many of the papers are very technical. I found this one (link below) to be a bit easier to read. All these reports suggests grape seed acts as an AI. Since I'm pre-meno, this might not be very helpful to me. (it also makes me wonder if anyone has done studies on the bone health of women while they are taking grape seed. Somehow there is still conflicting info on tamox and pre-meno women and that drug has been around for decades.) Anyway, the paper on grape seed extra and BC:
Thanks for the other link. I've only had a chance to skim it (and haven't read any of the references) but this paragraph on DIM (below) is a bit alarming to me. Anyone else?
Even my RO recommends eating cruciferous veggies to reduce the risk of recurrence, so I think there is something beneficial there. I just haven't done enough research to know whether the benefits of supplements outweigh any potential risks.
Anyway, here's the info on DIM:
What are some of DIM’s “opposite effects” on breast cancer cells?
I3C studies show that I3C stops the growth of estrogen receptor-positive and negative breast cancer cells in culture. DIM reportedly either makes estrogen receptor positive breast cancer cells grow or inhibits them in culture. According to researchers at the University of California, DIM promotes the growth of human breast cancer cells about as half as well as estrogen when no estrogen is present in the culture. In addition, DIM’s inhibition of cancer cell growth was “weak” in the presence of estrogen. Remember, these are laboratory conditions only and probably don’t occur in real life. How DIM behaves, however, may depend on dose. Researchers at Texas A&M report that DIM significantly counteracts estrogen-induced growth of MCF-7 cells in culture at higher doses. However, unlike I3C which retards the growth of estrogen receptor negative breast cancer cells, DIM has no effect on estrogen receptor negative cells. Another question about DIM is whether it can increase aromatase in breast and other tissue. Aromatase is an enzyme that helps create estrogen. DIM reportedly enhances the enzyme in adrenocortical cancer cells.
Not only is DIM not responsible for the anti-cancer effects of I3C, it has fewer anti-cancer effects (due to fewer molecular mechanisms), when it’s isolated from the other phytochemicals that naturally occur with it.
2/2011, IDC, <1cm, Stage IA, Grade 1, 0/3 nodes, ER+/PR+, HER2-