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Topic: Indole-3-carbinol

Forum: Alternative Medicine —

This forum is a safe, judgement-free place to discuss Alternative medicine. Alternative medicine refers to treatments that are used INSTEAD of standard, evidence-based treatment. does NOT recommend or endorse alternative medicine.

Posted on: May 11, 2017 03:10PM - edited Nov 6, 2017 09:48AM by froid89

froid89 wrote:

Have sombody had experience with Indole-3-carbinol supplement? My friend told me that it has kinda magic effect in some cases? I'm used hoodia supplements for weight loss. And was found out here - that hoodia converts testosterone to estrogen. Now I need some good estrogen suppressant.

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May 12, 2017 04:22AM froid89 wrote:

Indole 3-carbinol has cancer-preventive effects, but it has not been shown to treat cancer in humans.

Indole-3-carbinol, also called I3C, is a resulting compound that comes from eating vegetables such as Brussels sprouts, cabbage, cauliflower, broccoli, and kale. It is known to stimulate detoxifying enzymes in the gut and liver. Because diets high in these vegetables slow cancer growth in animals, I3C is thought to be a good candidate for cancer prevention. Laboratory studies show that I3C may have anticancer activities across a variety of tumor types, and may have added benefit with some chemotherapy drugs. However, other animal studies suggest that I3C might also promote tumor growth. Additional studies and human clinical trials are needed to determine the circumstances under which I3C might be suitable for cancer prevention.

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May 12, 2017 06:33AM - edited May 12, 2017 06:34AM by froid89

Indole 3 carbinol, DIM and the treatment of cancer

In 2004/5 we told you that the Pharmaceutical company, Hoechst, had been trying to patent a number of close relatives and synthetic versions of Indole 3 carbinol (I3C). What´s the fuss, especially given that most people reading this piece have hardly heard of this compound anyway? Well, Hoechst claimed that eventually these new compounds (Indole drugs) will be used to treat all manner of illnesses from arthritis to MS to cancer and, in time, even replace Tamoxifen with a far better alternative.

Great for patients not so good for Tamoxifen profits

In Cancer Watch (icon 2006 issue 4), we covered research that showed women on tamoxifen needed less of the drug if they supplemented with Indole 3 Carbinol, delivering the same benefits whilst reducing side effects. (Great for patients not so good for Tamoxifen profits.) Surprisingly, as we discovered when we looked into this further, this has apparently been consistently noted in a great number of studies. We wonder how many doctors and oncologists use this research?

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May 12, 2017 09:45AM dtad wrote:

Hi everyone. I'm taking it in leu of anti hormone therapy. What would you like to know?

Dx 3/20/2015, IDC, Left, 1cm, Stage IA, Grade 2, ER+/PR+, HER2- Dx 4/10/2015, ILC, 1cm, Stage IA, Grade 2, ER+/PR+, HER2- Surgery 5/21/2015 Lymph node removal: Sentinel; Mastectomy: Left, Right; Reconstruction (left): Silicone implant; Reconstruction (right): Silicone implant
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May 12, 2017 12:21PM dlb823 wrote:

I used I3C in lieu of hormone replacement therapy after a horrible SE experience with Letrozole. I also did some hormone balancing things, including Testosterone, recommended by a great naturopathic doc with oncology credentials, as well as walked 5 to 6 miles a day and worked out with a trainer. My outcome was a metastatic recurrence 6 years post my original Stage II dx. In my mind, it probably would have happened either way, as I had some extenuating circumstances surrounding my dx & tx, including a node with extracapsular extension and a delay in starting chemo. But what was interesting to me is that my first line of tx for Stage IV mets to bone was Anastrozole, with which I had no major SEs to speak of, and which successfully knocked back my diffuse and extensive (and painful) bone mets for 18 mos. The conclusion I think is worth sharing here is that the A/Is are far more powerful drugs than many realize when they're RX'd after an early stage bc dx. Also, that if you have a problem with one of them, there are 2 others, as well as many generic & brand name variants, all of which have slightly different compositions and fillers that can make a difference in SEs, or the lack thereof. Just my personal experience on this topic... Deanna

Deanna "The soul would have no rainbow if the eyes had no tears" Native American proverb Dx 2/1/2008, 1cm, Stage IIA, Grade 3, 1/16 nodes, ER+/PR+, HER2- Dx 1/3/2014, Stage IV
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May 13, 2017 04:45AM Momine wrote:

Deanna, Thanks for weighing in.

I am puzzled by the testosterone as "hormone balancing." The way I understood it, women's bodies turn testosterone into estrogen, unless this process is blocked by an AI. Then again, my knowledge is obviously limited. Do you recall how this naturopath explained/justified the treatment?

Dx 6/1/2011, ILC, 5cm, Stage IIIB, Grade 2, 7/23 nodes, ER+/PR+, HER2- Chemotherapy 6/19/2011 Cytoxan (cyclophosphamide), Ellence (epirubicin), Fluorouracil (5-fluorouracil, 5-FU, Adrucil), Taxotere (docetaxel) Surgery 9/12/2011 Mastectomy: Left, Right Radiation Therapy 1/8/2012 Surgery 3/7/2012 Prophylactic ovary removal Hormonal Therapy 3/31/2012 Femara (letrozole)
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May 18, 2017 11:59PM dlb823 wrote:

Hi, Momine ~ Just seeing your question now, and yes, you are correct, testosterone, as I understand it, can be converted to estrogen, although I'm not sure which form of estrogen without doing some research. In my case, the testosterone was RX'd in a very small dose, mostly to improve sexual response (that frustration we all know all too well after bc surgery!). I was also on either DHA or DHEA -- forget which one now, as it's been a few years. And my ND wanted me on an estrogen as well, but I never could get comfortable with that one, so refused it. It wasn't until after my recurrence that I read that testosterone is converted to estrogen, and wondered how wise it really was to ever use it...

Deanna "The soul would have no rainbow if the eyes had no tears" Native American proverb Dx 2/1/2008, 1cm, Stage IIA, Grade 3, 1/16 nodes, ER+/PR+, HER2- Dx 1/3/2014, Stage IV

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