Join Us

We are 217,647 members in 84 forums discussing 160,665 topics.

Help with Abbreviations

Topic: Triple negative bone mets after hormone pos breast cancer.

Forum: Mixed Type Breast Cancer — Meet others who have mixed type breast cancer.

Posted on: Jul 16, 2012 04:54PM

sharm wrote:

After 5 years of remission BR 15-3 started slowly rising.  At 6 years, bone mets showed up on MRI with contrast (bone scans, cat scans, and pet scans negative).   Taking Xeloda and getting monthly Xgeva injection.  Br 15-3 returned to normal after several months of treatment, and no longer have hip pain.  After 8 months of treatment, am currently stable.  Scheduled to remain on this treatment as long as it is effective.  Would like to hear of other cases in which original breast cancer was hormone positive, but returned as triple negative.

Log in to post a reply

Page 1 of 1 (11 results)

Posts 1 - 11 (11 total)

Log in to post a reply

Oct 5, 2012 08:18AM HLB wrote:

Hi, sorry there have been nio replies. I think this actually happens a lot with the receptors changing. I recently was dx with spinal mets but they were not biopsied. I think if the tx would not work then he would probably bx them but since its working, may as well not. I wonder if it happens as a way to resist treatment. I had not taken tamox so now the letroxole might be working well due to me being naïve to hormonal tx. Maybe you've gotten some responses elsewhere. This is the first time I came to this section of the board. There's a bone mets thread in the stage 4 forum that's pretty active. Glad your tx is working. :-)

Dx 10/2004, IDC, 1cm, Stage IIA, Grade 2, 2/11 nodes, ER+/PR+, HER2- Surgery 10/30/2004 Lumpectomy: Left; Lymph node removal: Left, Sentinel Surgery 11/30/2004 Lymph node removal: Left, Underarm/Axillary; Mastectomy: Left, Right; Prophylactic mastectomy: Right; Reconstruction (left): Tissue expander placement; Reconstruction (right): Tissue expander placement Chemotherapy 1/2/2005 AC + T (Taxol) Surgery 9/15/2005 Reconstruction (left); Reconstruction (right) Dx 7/23/2012, IDC, Stage IV Hormonal Therapy 7/23/2012 Femara (letrozole) Hormonal Therapy 4/1/2015 Aromasin (exemestane)
Log in to post a reply

Oct 5, 2012 09:51AM sharm wrote:

Thanks for the reply.  I'll check out the bone mets thread in the stage 4 forum.  It seems to me that biopsies on recurrence have become important.  My doctor changed my treatment plan due to the biopsy coming back triple negative.   

Log in to post a reply

Oct 7, 2012 08:53AM - edited Jul 27, 2020 09:39AM by TectonicShift

This Post was deleted by TectonicShift.
Log in to post a reply

Oct 9, 2012 05:33PM BlessedOne2 wrote:

I just happened to see your post.  I was triple positive BC in 2009.  On Anastrozole for 2 years now.  Recent xrays show some degenerative changes and narrowing of spinal canal.   What symptoms did you have that lead to the latest diagnosis? 

Dx 4/6/2009, IDC, 2cm, Stage IIA, Grade 3, 0/3 nodes, ER+/PR+, HER2+ Surgery 6/10/2009 Lumpectomy: Right Chemotherapy 7/15/2009 AC + T (Taxol) Targeted Therapy 11/11/2009 Herceptin (trastuzumab) Radiation Therapy 1/23/2010 Breast Hormonal Therapy 3/5/2010 Arimidex (anastrozole)
Log in to post a reply

Oct 10, 2012 01:31AM HLB wrote:

Hi, mine was found by tumor marker. I didn't have any symptoms. They did a bone scan and the spinal mets were found. There were also some degenerative changes in knees and shoulder but it was easy to see the difference between those and the mets.

Dx 10/2004, IDC, 1cm, Stage IIA, Grade 2, 2/11 nodes, ER+/PR+, HER2- Surgery 10/30/2004 Lumpectomy: Left; Lymph node removal: Left, Sentinel Surgery 11/30/2004 Lymph node removal: Left, Underarm/Axillary; Mastectomy: Left, Right; Prophylactic mastectomy: Right; Reconstruction (left): Tissue expander placement; Reconstruction (right): Tissue expander placement Chemotherapy 1/2/2005 AC + T (Taxol) Surgery 9/15/2005 Reconstruction (left); Reconstruction (right) Dx 7/23/2012, IDC, Stage IV Hormonal Therapy 7/23/2012 Femara (letrozole) Hormonal Therapy 4/1/2015 Aromasin (exemestane)
Log in to post a reply

Oct 10, 2012 12:48PM sharm wrote:

At first no symptoms, but tumor marker BR15-3 started rising slowly.  My doctor started checking me more closely and checking tumor markers monthly.  They continued to rise very slowly, but nothing showed on PET, CAT, or bone scans.  After 1.5 years hip started hurting.  An MRI revealed very small tumors in hip and lower spine.  Biopsy showed that it was breast cancer mets.  I've talked to other people whose doctors don't routinely check tumor markers.  Hope your treatment goes well.

Log in to post a reply

Oct 24, 2014 02:39PM MissingAlley wrote:

Sharm,

Be grateful your MO was doing tumor markers because mine did not.  Mine went from ER+ & Her2- to ER+ & Her2+.  My back started hurting a few months ago.  Cancer Bone Mets has taken over my lower spine and a few area area of the femur bone and hip.  Hope your treatment goes well,.  They a radiating my spine right now for pain relief.  I agree this stuff can drive you insane. 

Log in to post a reply

Nov 13, 2014 06:55AM coffeelatte wrote:


I read this thread last night and I kept coming back to something TectonicShift wrote, "Think about it. If your tumor is, say, 60% er+, then it's 40% er-. That means 40% of the cells in the tumor are er-."

I had never thought about it in that way before.  I guess I thought if your tumor was 60% ER+, then the rest of the tumor was made up of the progesterone receptor, or non-cancerous tissue.  So does that mean a breast cancer tumor is always 100% cancer and that it is either 100% ER+ or some mix of ER+ and ER-?

Dx 7/2/2013, Grade 3, ER-/PR- Surgery 8/12/2013 Lymph node removal; Mastectomy: Left, Right
Log in to post a reply

Nov 16, 2014 07:58AM Annette47 wrote:

I think your question was also answered on another thread that you posted it too, but my understanding is that the percentage ER+ refers to the percent of the cancer cells that have estrogen receptors - in other words that can feed on estrogen. Those same cells might or might not have progesterone receptors as well, which is why the ER+ and the PR+ numbers don't add to 100 ... both of mine were >90%. In your example of 60% ER+ that would mean that 40% of the cancer cells are not capable of feeding on estrogen and would not therefore be affected by Tamoxifen or AI's. The progesterone numbers would be relatively independent of that (although they do tend to go together).

Dx 11/20/2012, DCIS, <1cm, Stage 0, Grade 2, 0/3 nodes, ER+/PR+ Dx 11/20/2012, IDC, <1cm, Stage IA, Grade 2, 0/3 nodes, ER+/PR+ Surgery 12/17/2012 Lumpectomy: Left; Lymph node removal: Left, Sentinel Radiation Therapy 1/20/2013 Breast Hormonal Therapy 3/31/2013
Log in to post a reply

Nov 16, 2014 07:27PM coffeelatte wrote:

Annette thank you for the response. When I was first diagnosed I knew nothing about breast cancer.  Now that I am more than a year out I find I still get very confused by it all at times.  I do see what you mean about the receptors on the cancer cells.  Maybe that is why the breast cancer can metastasize to a different part of the body and have a different hormone status when biopsied.  This happened to a friend of mine and I have struggled to understand it.  She had an IDC that was ER+/PR+ but it metastasized to the spine in spite of treatment and it was ER-/PR-.  I have never understood how the cancer status changed, but maybe some of the original cells were negative?  So confusing.

Dx 7/2/2013, Grade 3, ER-/PR- Surgery 8/12/2013 Lymph node removal; Mastectomy: Left, Right
Log in to post a reply

Jan 11, 2015 10:14PM - edited Jan 11, 2015 10:17PM by jjseven22

I dont understand. I was er+pr+her2- in 2002. In 2012 relapased to METS. In 2014 the hormone positive cancer was given an NED then in the same sentence was told I have a tumor in the mediastinum that is now triple negative. I am not Brca gene positive. What is the response rate for someone with tnbc that is not brca gene positive. What therapy drugs has everyone had with a positive response. I am so confused and angry. I am on gemzar carboplatin. I am feeling hopeless.

Page 1 of 1 (11 results)