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Topic: Hetergenous Tumor - ER+ and TN in same Tumor

Forum: Mixed Type Breast Cancer — Meet others who have mixed type breast cancer.

Posted on: Jul 26, 2012 08:46PM

dimplesnwinks wrote:

I was diagnosed in February.  Originally, my tumor tested out ER+ (83%), PR-, Her2-.  My tumor was sent for the Oncotype DX test and the results came back Triple Negative.  Had the tumor tested out numerous times and came back that some portions were ER+, some were TN, and some were weakly positive. 

My tumor was 1.0x1.0x1.5, 0/4 nodes, no skin involvement, no chest wall involvement, no nipple involvement, Stage Ia.  I had 4 Taxotere/Cytoxan.  Now will begin either Tamoxifen or AI's depending on my lab work.  (Last period was last Labor Day weekend.)

Has anyone else had both ER+ and TN in the same tumor?  Genomic Health is now going to start tracking this type of tumor (and wanted my permission to use my stats).  I've been told this occurs in only 2% of all BC.  It's the first time my oncologist has seen it and he's been practicing for 30 years.  

Dx 2/17/2012, IDC, 1cm, Stage IA, Grade 3, 0/4 nodes, ER-/PR-, HER2- Dx 2/17/2012, IDC, 1cm, Stage IA, Grade 3, 0/4 nodes, ER+/PR-, HER2- Surgery 3/21/2012 Lumpectomy: Left; Lymph node removal: Right, Sentinel; Mastectomy: Right Chemotherapy 5/16/2012 Cytoxan (cyclophosphamide), Taxotere (docetaxel) Hormonal Therapy 9/6/2012 Femara (letrozole) Surgery 9/24/2012 Mastectomy: Left; Reconstruction (left): Tissue expander placement; Reconstruction (right): Tissue expander placement
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Aug 3, 2012 07:41PM Gitane wrote:

My IHC results were ER strongly positive, PR no staining at all, and Her2 1+,  my Oncotype DX showed ER low positive, PR very low positive, and Her2  was not reported by Oncotype at that time (they started reporting it 2 weeks after mine was run!)  FISH test was 1.66 (called duplicated, not amplified)

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