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Topic: Two tumors, same quadrant, two different types

Forum: Mixed Type Breast Cancer — Meet others who have mixed type breast cancer.

Posted on: Jan 28, 2013 10:04AM

LoriBach wrote:

Here is my story...I have (or had) two tumors in my right breast with different pathology.

Larger Tumor:  ER-/PR- and HER2+

Smaller Tumor:  ER+/PR+ and HER2-

Any one else have similar situation?

Lori Dx 5/14/2012, IDC, Right, 2cm, Stage IIB, Grade 3, 1/16 nodes, ER+/PR+, HER2+ (FISH) Chemotherapy 8/15/2012 Carboplatin (Paraplatin), Taxotere (docetaxel) Hormonal Therapy 1/11/2013 Targeted Therapy Herceptin (trastuzumab)
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Feb 26, 2013 07:29PM drlauralee wrote:

My best friend just got dianosed with two types of breast cancer in her left breast.  I'm learning the lingo, so please excuse me if I don't get this right.  She has a total of 4 tumors in her left breast and so far one is estrogen based, the second one isn't.  She is grade 3.  She hasn't had the other 2 biolpsied yet.  She's going to have a mastectomy on the left side.  There's another tumor in her milk duct on the right side.  She's developed blood clots in her legs.

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Mar 5, 2013 04:54PM winterapril wrote:

Hope more people can share the experience.  I've always thought that primary tumor will all just have the same type...

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Mar 19, 2013 11:48AM winterapril wrote:

Based on this article, apprently, the receptor status test can be erroneous just as any other tests.  From where the sample is extracted to how it's prepared, there are many ways of introducing the error.  It makes sense that if the doctor had sampled the center of the large tumor, it'll be relatively negative because the middle of the tumor is relatively ischemic and will have little reactivity. On top of all that, it's said that the receptor status can change. The whole tumor thing is really a big unknown medically.  Trial and error is probably the only thing that can be done at this point given the current research level.

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Apr 10, 2013 04:40PM SoLinda wrote:

I had my surgery at a different hospital than my chemo.  At the first hospital, the receptor status was incorrect and said that the cancer wasn't estrogen positive and that it was a good idea to have the tissue tested again.  So, it was tested again at the second hospital and yes, it turned out to be 60% estrogen positive and 80% progesterone positive.  I had invasive ductal carcinoma - 2 cm. tumour in my left breast, and also another area of the same breast which was in situ which had never shown up on any prior scan or biopsy ...  Onc. No. 2 said it certainly was a good thing that I had had the entire breast removed ...  And after my experience with chemo., I have to mention how incredibly important it is to be wary of blood clot signs ...  I had a severe pulmonary embolism only a few days after my last chemo. and am lucky to be alive.  I have been informed that not only can some chemo. drugs influence the development of blood clots, but that cancer patients' blood is in a state of hypercoagulation.  I am taking warfarin because of the pulmonary embolism, and will be taking it at least until I finish taking Arimidex-Anastrozole in another 3 years.  Yippee  Laughing 

Dx 6/29/2010, IDC, 2cm, Stage IIA, Grade 2, 0/8 nodes, ER+/PR+, HER2- Dx 9/2/2010, DCIS, 5cm, Stage I, Grade 1, 0/8 nodes, ER+/PR+, HER2- Surgery 9/2/2010 Lymph node removal: Left; Mastectomy: Left; Reconstruction (left); Reconstruction (right) Chemotherapy 1/28/2011 Adriamycin (doxorubicin), Cytoxan (cyclophosphamide), Fluorouracil (5-fluorouracil, 5-FU, Adrucil) Hormonal Therapy 6/14/2011 Arimidex (anastrozole), Femara (letrozole) Hormonal Therapy 8/21/2013 Femara (letrozole)
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Jan 25, 2014 11:13AM marvelher2 wrote:

My primary tumor is strongly ER/PR negative (0%) and strongly Her2 positive (3+++).  This is at 11:00 anteriorly on my right breast.  Now, they found a small tumor at 9:00 posteriorly on the completely opposite side of my breast through an MRI guided biopsy and this one is ER+ (90%) PR+(50%) and Her2 negative (only 10% staining).

Bottom line, they are calling this a completely new and separate cancer occurrence.  With this news, my plans are changing from hoping for a lumpectomy to probably bilateral mastectomy.  Ugghhh!

Dx 11/26/2013, IDC, 5cm, Grade 2, ER-/PR-, HER2+ Dx 1/10/2014, IDC, <1cm, Stage IA, Grade 1, ER+, HER2- Targeted Therapy 1/13/2014 Herceptin (trastuzumab) Targeted Therapy 1/13/2014 Perjeta (pertuzumab) Chemotherapy 1/13/2014 Carboplatin (Paraplatin), Taxotere (docetaxel) Surgery 5/29/2014 Mastectomy: Right; Prophylactic mastectomy: Left; Reconstruction (left); Reconstruction (right) Dx 5/30/2014, DCIS, Stage 0, Grade 3, 0/6 nodes, ER+/PR+, HER2- Dx 5/30/2014, IDC, <1cm, Stage 0, Grade 1, 0/6 nodes, ER+/PR+, HER2- Dx 5/30/2014, IDC, 3cm, Stage IIA, Grade 2, 0/6 nodes, ER-/PR-, HER2+ Hormonal Therapy Hormonal Therapy Femara (letrozole)

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