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Topic: Pathology test showed ILC & E-Cadherin showed IDC

Forum: Mixed Type Breast Cancer — Meet others who have mixed type breast cancer.

Posted on: Jul 31, 2017 02:53AM

LCY wrote:

HI. I am new to the group and I am still learning about breast cancer. I have undergone total mastectomy with sentinel lymph node dissection last June 28, My cancer was Stage 1A, nuclear grade 1. Prior to surgery, a core needle biopsy was done which came back with the results of Invasive Lobular Cancer (ILC). The Pathology report done after the mastectomy correlated the same findings - ILC, but suggested that E-Cadherin test be done. The E-Cadherin test results came back with Invasive Ductal Carcinoma. The tumor is only 1.1 cm and is ER+, PR+, HER2-.

Initially, I was told that I might not need to undergo chemotherapy anymore due to the low stage. None of the lymph nodes tested/removed indicated cancer. However, due to the results of the E-Cadherin test, I am now told that there is still the possibility of undergoing chemo.

What does this mean? And what is the difference in treating ILC, IDC, or mixed type cancer?

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Jul 31, 2017 02:00PM kira1234 wrote:

I'm not sure why being IDC rather than ILC would change chemo for stage 1. I'd request the oncotype test or the mammaprint test be done

Dx 6/2010, ILC, Left, <1cm, Stage IA, Grade 1, 0/1 nodes, ER+/PR+, HER2- Surgery 7/8/2010 Lumpectomy: Left; Lymph node removal: Left, Right, Sentinel Radiation Therapy 8/3/2010 Hormonal Therapy 10/5/2010 Aromasin (exemestane) Dx 2/2017, ILC, Left, <1cm, Stage IA, Grade 1, 0/2 nodes, ER+/PR-, HER2- Surgery Lymph node removal: Sentinel; Mastectomy: Left, Right Hormonal Therapy Arimidex (anastrozole)
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Jul 31, 2017 03:19PM Mucki1991 wrote:

Hi, I too have mixed mine is, Invasive high-grade mammary carcinoma with mixed ductal, lobular and micropapillary features, node-positive. I'm not sure either why it would change whether or not you would chemo. I am curious as to how common mixed cancers are? I am meeting with my onc for the first time next week and I eager to find out his views on this. I had my BMX on the 14th so I'm really just getting to the treatment stage now.

Rebekah Dx 5/5/2017, ILC/IDC/IDC: Papillary, Left, 3cm, Stage IIB, Grade 3, 3/7 nodes, ER+/PR+, HER2- (IHC) Surgery 7/13/2017 Mastectomy: Left; Prophylactic mastectomy: Right; Reconstruction (left): Tissue expander placement; Reconstruction (right): Tissue expander placement Chemotherapy 8/22/2017 AC + T (Taxol) Surgery 2/8/2018 Reconstruction (left): Silicone implant; Reconstruction (right): Silicone implant Radiation Therapy 2/25/2018 3DCRT: Breast, Lymph nodes, Chest wall Hormonal Therapy 4/19/2018 Tamoxifen pills (Nolvadex, Apo-Tamox, Tamofen, Tamone) Surgery 9/17/2018 Reconstruction (left): DIEP flap; Reconstruction (right): DIEP flap Surgery 1/24/2019
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Jul 31, 2017 05:20PM letsgogolf wrote:

I think it is fairly common to have mixed tumors.. Mine was IDC with Lobular features, grade 1. I have been told that 50% of this type of tumor involve 1 node only and that they are less likely to cause mets. They also have a higher rate of second primary tumors.

Oncotype DX = 3. IDC with Lobular Features. Sentinel Node had Micrometastases - Estrogen 100%, Progesterone 99.89%, Ki67= 3.3% Dx 2/14/2017, IDC, Left, 1cm, Stage IB, Grade 1, 0/8 nodes, ER+/PR+, HER2- Surgery 2/27/2017 Lumpectomy: Left Radiation Therapy 4/6/2017 Whole-breast: Lymph nodes Hormonal Therapy 6/1/2017 Arimidex (anastrozole) Targeted Therapy
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Nov 16, 2017 08:19PM beach2beach wrote:

Not sure LCY if you are on here any longer, but I was initially diagnosed on biopsy as IDC. After surgery, pathology came back as ILC so they had to check the nodes with a different type of stain to make sure it had not spread. My pathology also came back as well with DCIS and LCIS as well. All in a 7mm tumor.

Dx 7/28/2017, LCIS/DCIS/ILC, Right, <1cm, Stage IA, Grade 1, 0/2 nodes, ER+/PR+, HER2- Surgery 8/8/2017 Mastectomy: Left, Right; Reconstruction (left); Reconstruction (right) Hormonal Therapy 9/12/2017 Tamoxifen pills (Nolvadex, Apo-Tamox, Tamofen, Tamone)

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